Al Dera, H. S. (2016). Protective effect of resveratrol against aluminum chloride induced nephrotoxicity in rats. Saudi Medical Journal, 37, 369–378.

Article  PubMed  Google Scholar 

Obafemi, T. O., Anyalechi, D. I., Afolabi, B. A., Ekundayo, B. E., Adewale, O. B., Afolabi, O. B., Anadozie, S. O., Olaoye, O. A., Adu, I. A., & Onasanya, A. (2022). Nephroprotective effects of gallic acid and hesperidin in aluminum chloride-induced toxicity in rats. Phytomedicine Plus, 2, 100378.

Article  Google Scholar 

Othman, M. S., Fareid, M. A., Abdel Hameed, R. S., & Abdel Moneim, A. E. (2020). The protective effects of melatonin on aluminum-induced hepatotoxicity and nephrotoxicity in rats. Oxidative Medicine and Cellular Longevity, 2020, 7375136.

Article  PubMed  PubMed Central  Google Scholar 

Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019). Aluminium toxicosis: a review of toxic actions and effects. Interdisciplinary Toxicology, 12, 45–70.

Article  CAS  PubMed  Google Scholar 

El-Demerdash, F. M., Baghdadi, H. H., Ghanem, N. F., & Al Mhanna, A. B. (2020). Nephroprotective role of bromelain against oxidative injury induced by aluminium in rats. Environmental Toxicology and Pharmacology, 80, 103509.

Article  CAS  PubMed  Google Scholar 

Lapi, F., Azoulay, L., Yin, H., Nessim, S. J., & Suissa, S. (2013). Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. BMJ, 346, e8525.

Article  PubMed  PubMed Central  Google Scholar 

Ohno, S., Ishii, A., Yanagita, M., & Yokoi, H. (2022). Calcium channel blocker in patients with chronic kidney disease. Clinical and Experimental Nephrology, 26, 207–215.

Article  CAS  PubMed  Google Scholar 

Anadozie, S. O., Akinyemi, J. A., Agunbiade, S., Ajiboye, B. O., & Adewale, O. B. (2018). Bryophyllum pinnatum inhibits arginase II activity and prevents oxidative damage occasioned by carbon tetrachloride (CCl4) in rats. Biomedicine & Pharmacotherapy, 101, 8–13.

Article  CAS  Google Scholar 

Bencheikh, N., Elbouzidi, A., Kharchoufa, L., Ouassou, H., Alami Merrouni, I., Mechchate, H., Es-Safi, I., Hano, C., Addi, M., & Bouhrim, M. (2021). Inventory of medicinal plants used traditionally to manage kidney diseases in north-eastern Morocco: Ethnobotanical fieldwork and pharmacological evidence. Plants, 10(9), 1966.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nurfaradilla, S. A., Saputri, F. C., & Harahap, Y. (2019). Effects of Hibiscus sabdariffa calyces aqueous extract on the antihypertensive potency of captopril in the two-kidney-one-clip rat hypertension model. Evidence-Based Complementary and Alternative Medicine, 2019, 694212.

Article  Google Scholar 

Riaz, G., & Chopra, R. (2018). A review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L. Biomedicine & Pharmacotherapy, 102, 575–586.

Article  CAS  Google Scholar 

Oboh, G., Adewuni, T. M., Ademiluyi, A. O., Olasehinde, T. A., & Ademosun, A. O. (2018). Phenolic constituents and inhibitory effects of Hibiscus sabdariffa L. (Sorrel) calyx on cholinergic, monoaminergic, and purinergic enzyme activities. Journal of Dietary Supplements, 15, 910–922.

Article  CAS  PubMed  Google Scholar 

Wang, C.-J., Wang, J.-M., Lin, W.-L., Chu, C.-Y., Chou, F.-P., & Tseng, T.-H. (2000). Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food and Chemical Toxicology, 38(5), 411–416.

Article  CAS  PubMed  Google Scholar 

Sáyago‐Ayerdi, S. G., Velázquez‐López, C., Montalvo‐González, E., & Goñi, I. (2014). By‐product from decoction process of Hibiscus sabdariffa L. calyces as a source of polyphenols and dietary fiber. Journal of the Science of Food and Agriculture, 94(5), 898–904.

Article  PubMed  Google Scholar 

Han, X., Xu, K., Taratula, O., & Farsad, K. (2019). Applications of nanoparticles in biomedical imaging. Nanoscale, 11, 799–819.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cabuzu, D., Cirja, A., Puiu, R., & Mihai Grumezescu, A. (2015). Biomedical applications of gold nanoparticles. Current Topics in Medicinal Chemistry, 15, 1605–1613.

Article  CAS  PubMed  Google Scholar 

Anadozie, S. O., Adewale, O. B., Fadaka, A. O., Afolabi, O. B., & Roux, S. (2022). Synthesis of gold nanoparticles using extract of Carica papaya fruit: Evaluation of its antioxidant properties and effect on colorectal and breast cancer cells. Biocatalysis and Agricultural Biotechnology, 42, 102348.

Article  CAS  Google Scholar 

Anadozie, S. O., Adewale, O. B., Meyer, M., Davids, H., & Roux, S. (2021). In vitro anti-oxidant and cytotoxic activities of gold nanoparticles synthesized from an aqueous extract of the Xylopia aethiopica fruit. Nanotechnology, 32, 315101.

Article  CAS  Google Scholar 

Anadozie, S. O., Adewale, O. B., Sibuyi, N. R. S., Fadaka, A. O., Isitua, C. C., Davids, H., & Roux, S. (2023). One-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kola. Process Biochemistry, 128, 49–57.

Article  CAS  Google Scholar 

Zangeneh, M. M., & Zangeneh, A. (2020). Novel green synthesis of Hibiscus sabdariffa flower extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia effect in comparison to daunorubicin in a leukemic rodent model. Applied Organometallic Chemistry, 34, e5271.

Article  CAS  Google Scholar 

Anadozie, S. O., Effiom, D. O., Adewale, O. B., Jude, J., Zosela, I., Akawa, O. B., Olayinka, J. N., & Roux, S. (2023). Hibiscus sabdariffa synthesized gold nanoparticles ameliorate aluminum chloride induced memory deficits through inhibition of COX-2/BACE-1 mRNA expression in rats. Arabian Journal of Chemistry, 16, 104604.

Article  CAS  Google Scholar 

Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95, 351–358.

Article  CAS  PubMed  Google Scholar 

Miranda, K. M., Espey, M. G., & Wink, D. A. (2001). A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62–71.

Article  CAS  PubMed  Google Scholar 

Ellman, G. L. (1959). Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82, 70–77.

Article  CAS  PubMed  Google Scholar 

Alía, M., Horcajo, C., Bravo, L., & Goya, L. (2003). Effect of grape antioxidant dietary fiber on the total antioxidant capacity and the activity of liver antioxidant enzymes in rats. Nutrition Research, 23, 1251–1267.

Article  Google Scholar 

Breyer, M. D., & Susztak, K. (2016). The next generation of therapeutics for chronic kidney disease. Nature Reviews Drug Discovery, 15, 568–588.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kellum, J. A., Romagnani, P., Ashuntantang, G., Ronco, C., Zarbock, A., & Anders, H.-J. (2021). Acute kidney injury. Nature Reviews Disease Primers, 7, 52.

Article  PubMed  Google Scholar 

Norris, K. C., Smoyer, K. E., Rolland, C., Van der Vaart, J., & Grubb, E. B. (2018). Albuminuria, serum creatinine, and estimated glomerular filtration rate as predictors of cardio-renal outcomes in patients with type 2 diabetes mellitus and kidney disease: a systematic literature review. BMC Nephrology, 19, 1–13.

Article  Google Scholar 

Ghasemi, M., Nematbakhsh, M., Daneshmand, F., Moeini, M., & Talebi, A. (2015). Role of nitric oxide in kidney and liver (as distance organ) function in bilateral renal ischemia-reperfusion: Effect of l-Arginine and NG-nitro-l-Arginine methyl ester. Advanced Biomedical Research, 2015(4), 233.

Google Scholar 

Akinyemi, A. J., Onyebueke, N., Faboya, O. A., Onikanni, S. A., Fadaka, A., & Olayide, I. (2017). Curcumin inhibits adenosine deaminase and arginase activities in cadmium-induced renal toxicity in rat kidney. Journal of Food and Drug Analysis, 25, 438–446.

Article  CAS  PubMed  Google Scholar 

Sies, H. (2015). Oxidative stress: a concept in redox biology and medicine. Redox Biology, 4, 180–183.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rani, V., Deep, G., Singh, R. K., Palle, K., & Yadav, U. C. S. (2016). Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sciences, 148, 183–193.

Article  CAS