AMPK Regulates M1 Macrophage Polarization through the JAK2/STAT3 Signaling Pathway to Attenuate Airway Inflammation in Obesity-Related Asthma

Suzuki, Y., Y. Aono, N. Akiyama, Y. Horiike, H. Naoi, et al. 2022. Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma. Autophagy 18: 2216–2228.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Savin, I.A., M.A. Zenkova, and A.V. Sen'kova. 2023. Bronchial asthma, airway remodeling and lung fibrosis as successive steps of one process. International Journal of Molecular Sciences 24 (22): 16042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boulet, L.P., J.M. FitzGerald, and H.K. Reddel. 2015. The revised 2014 GINA strategy report: Opportunities for change. Current Opinion in Pulmonary Medicine 21: 1–7.

Article  PubMed  Google Scholar 

Dixon, A.E., and L.G. Que. 2022. Obesity and asthma. Seminars in Respiratory and Critical Care Medicine 43: 662–674.

Article  PubMed  Google Scholar 

Althoff, M.D., A. Ghincea, L.G. Wood, F. Holguin, and S. Sharma. 2021. Asthma and three Colinear comorbidities: Obesity, OSA, and GERD. Journal of Allergy and Clinical Immunology: In Practice 9: 3877–3884.

PubMed  Google Scholar 

Kong, J., F. Yang, M. Bai, Y. Zong, Z. Li, et al. 2022. Airway immune response in the mouse models of obesity-related asthma. Frontiers in Physiology 13: 909209.

Article  PubMed  PubMed Central  Google Scholar 

Garcia-Rio, F., M.J. Alvarez-Puebla, I. Esteban-Gorgojo, P. Barranco, and J.M. Olaguibel. 2019. Obesity and asthma: Key clinical questions. Journal of Investigational Allergology and Clinical Immunology 29: 262–271.

Article  CAS  PubMed  Google Scholar 

Sharma, V., and D.C. Cowan. 2021. Obesity, inflammation, and severe asthma: An update. Current Allergy and Asthma Reports 21: 46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y., R. Wan, and C. Hu. 2023. Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages. Molecular Medicine 29: 100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bantula, M., J. Roca-Ferrer, E. Arismendi, and C. Picado. 2021. Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation. Journal of clinical medicine 10: 169.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Periyalil, H.A., L.G. Wood, T.A. Wright, C. Karihaloo, M.R. Starkey, et al. 2018. Obese asthmatics are characterized by altered adipose tissue macrophage activation. Clinical and Experimental Allergy 48: 641–649.

Article  CAS  PubMed  Google Scholar 

Das, A., M.P. Pathak, K. Pathak, R. Saikia, and U. Gogoi. 2023. Herbal medicine for the treatment of obesity-associated asthma: A comprehensive review. Frontiers in Pharmacology 14: 1186060.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin, X., Y. Zhang, X. Zhou, C. Lai, Y. Dong, and W. Zhang. 2024. Inhibition of soluble epoxide hydrolase relieves adipose inflammation via modulating M1/M2 macrophage polarization to alleviate airway inflammation and hyperresponsiveness in obese asthma. Biochemical Pharmacology 219: 115948.

Article  CAS  PubMed  Google Scholar 

Park, C.S., B.R. Bang, H.S. Kwon, K.A. Moon, T.B. Kim, et al. 2012. Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase. Biochemical Pharmacology 84: 1660–1670.

Article  CAS  PubMed  Google Scholar 

Xu, C., Y. Song, Z. Wang, J. Jiang, Y. Piao, et al. 2021. Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways. Immunity, Inflammation and Disease 9: 1406–1417.

Article  PubMed  PubMed Central  Google Scholar 

You, Y.N., Q.Q. Xing, X. Zhao, J.J. Ji, H. Yan, et al. 2021. Gu-ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission. Biomedicine and Pharmacotherapy 138: 111403.

Article  CAS  PubMed  Google Scholar 

Calixto, M.C., L. Lintomen, D.M. Andre, L.O. Leiria, D. Ferreira, et al. 2013. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. PLoS One 8: e76786.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsai, M.L., Y.G. Tsai, Y.C. Lin, Y.L. Hsu, Y.T. Chen, et al. 2021. IL-25 induced ROS-mediated M2 macrophage polarization via AMPK-associated Mitophagy. International Journal of Molecular Sciences 23: 3.

Article  PubMed  PubMed Central  Google Scholar 

Tian, L., M. Wang, Y. Wang, W. Li, and Y. Yang. 2024. Naringenin ameliorates atopic dermatitis by inhibiting inflammation and enhancing immunity through the JAK2/STAT3 pathway. Genes & Genomics 46: 333–340.

Article  CAS  Google Scholar 

Zhong, Y., T. Huang, J. Huang, J. Quan, G. Su, et al. 2023. The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation. Theranostics 13: 3568–3581.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang, Q., C. Xing, M. Li, Q. Jia, C. Bo, and Z. Zhang. 2022. Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways. Ecotoxicology and Environmental Safety 244: 114066.

Article  CAS  PubMed  Google Scholar 

Yang, Z., L. Yan, H. Cao, Y. Gu, P. Zhou, et al. 2021. Erythropoietin protects against diffuse alveolar hemorrhage in mice by regulating macrophage polarization through the EPOR/JAK2/STAT3 Axis. Journal of Immunology 206: 1752–1764.

Article  CAS  Google Scholar 

El-Ghannam, M.S., M.A. Saad, N.N. Nassar, M.F. El-Yamany, and A.A.Z. El-Bahy. 2022. Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats. Toxicology and Applied Pharmacology 438: 115906.

Article  CAS  PubMed  Google Scholar 

Xu, S., N. Wang, D. Yan, and Y. Zhong. 2023. Platycoside E alleviates allergic airway inflammation in obesity-related asthma mouse model. Molecular Immunology 162: 74–83.

Article  CAS  PubMed  Google Scholar 

Scott, H.A., L.G. Wood, and P.G. Gibson. 2017. Role of obesity in asthma: Mechanisms and management strategies. Current Allergy and Asthma Reports 17: 53.

Article  PubMed  Google Scholar 

Lin, W.T., H.H. Wu, C.W. Lee, Y.F. Chen, L. Huang, et al. 2024. Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization. Molecular Therapy--Nucleic Acids 35: 102102.

Article  CAS  PubMed  Google Scholar 

Jiao, Y., T. Zhang, C. Zhang, H. Ji, X. Tong, et al. 2021. Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. Critical Care (London, England) 25: 356.

Article  PubMed  Google Scholar 

Choi, Y., M. Kim, S.J. Kim, H.J. Yoo, S.H. Kim, and H.S. Park. 2020. Metabolic shift favoring C18:0 ceramide accumulation in obese asthma. Allergy 75: 2858–2866.

Article  CAS  PubMed  Google Scholar 

Russjan, E. 2024. The role of peptides in asthma-obesity phenotype. International Journal of Molecular Sciences 25 (6): 3213.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma, N., M. Akkoyunlu, and R.L. Rabin. 2018. Macrophages-common culprit in obesity and asthma. Allergy 73: 1196–1205.

Article  CAS  PubMed 

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