Anticancer Peptide MCP-1 Induces Ferroptosis in Liver Cancer HCCLM3 Cells by Targeting FOXM1/ALOXE3 Signal Pathway

Barger CJ, Branick C, Chee L, Karpf AR (2019) Pan-cancer analyses reveal genomic features of FOXM1 overexpression in Cancer. Cancers (Basel) 11(2):251. https://doi.org/10.3390/cancers11020251

Article  CAS  PubMed  Google Scholar 

Bella L, Zona S, Nestal de Moraes G, Lam EW-F (2014) FOXM1: a key oncofoetal transcription factor in health and disease. Semin Cancer Biol 29:32–39. https://doi.org/10.1016/j.semcancer.2014.07.008

Article  CAS  PubMed  Google Scholar 

Bi Z, Liu W, Ding R, Wu Y, Dou R, Zhang W, Yuan X, Liu X, Xiong L, Guo Z, Mao C (2017) A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression. Eur J Pharmacol 796:175–189. https://doi.org/10.1016/j.ejphar.2016.12.029

Article  CAS  PubMed  Google Scholar 

Chen Y, Li H (2022) Prognostic and predictive models for left- and right- colorectal Cancer patients: a Bioinformatics Analysis based on ferroptosis-related genes. Front Oncol 12:833834. https://doi.org/10.3389/fonc.2022.833834

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Kang R, Kroemer G, Tang D (2021) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18(5):280–296. https://doi.org/10.1038/s41571-020-00462-0

Article  CAS  PubMed  Google Scholar 

Dixon SJ, Pratt DA (2023) Ferroptosis: a flexible constellation of related biochemical mechanisms. Mol Cell 83(7):1030–1042. https://doi.org/10.1016/j.molcel.2023.03.005

Article  CAS  PubMed  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS et al (2012) Ferroptosis: An Iron-Dependent form of non-apoptotic cell death. Cell 149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gan B (2021) Mitochondrial regulation of ferroptosis. J Cell Biol 220(9):202105043. https://doi.org/10.1083/jcb.202105043

Article  CAS  Google Scholar 

Halasi M, Gartel AL (2013) Targeting FOXM1 in cancer. Biochem Pharmacol 85(5):644–652. https://doi.org/10.1016/j.bcp.2012.10.013

Article  CAS  PubMed  Google Scholar 

Hao X, Zheng Z, Liu H, Zhang Y, Kang J, Kong X, Rong D, Sun Guangshun S, Guoqiang, Liu L et al (2022) Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing. Redox Biol 56:102463. https://doi.org/10.1016/j.redox.2022.102463

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassannia B, Vandenabeele P, Vanden Berghe T (2019) Targeting ferroptosis to Iron Out Cancer. Cancer Cell 35(6):830–849. https://doi.org/10.1016/j.ccell.2019.04.002

Article  CAS  PubMed  Google Scholar 

Kalathil D, John S, Nair AS (2020) FOXM1 and Cancer: Faulty Cellular Signaling derails Homeostasis. Front Oncol 10:626836. https://doi.org/10.3389/fonc.2020.626836

Article  PubMed  Google Scholar 

Kuang F, Liu J, Tang D, Kang R (2020) Oxidative damage and antioxidant defense in Ferroptosis. Front Cell Dev Biol 8:586578. https://doi.org/10.3389/fcell.2020.586578

Article  PubMed  PubMed Central  Google Scholar 

Lei G, Zhuang L, Gan B (2022) Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer 22(7):381–396. https://doi.org/10.1038/s41568-022-00459-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Zhang Y, Liu J, Kang R, Klionsky DJ, Tang D (2020a) Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. Autophagy 17(4):948–960. https://doi.org/10.1080/15548627.2020.1739447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Huang Weimei, Huang Wenbin, Wei T, Zhu W, Chen G, Zhang J (2020b) Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. Am J Transl Res 12(5):1614–1639

CAS  PubMed  PubMed Central  Google Scholar 

Lin Z, Liu J, Long F, Kang R, Kroemer G, Tang D, Yang M (2022) The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis. Nat Commun 13(1):7965. https://doi.org/10.1038/s41467-022-35707-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu W, Ding R, Zhang Y, Mao C, Kang R, Meng J, Huang Q, Xiong L, Guo Z (2017) Transcriptome profiling analysis of differentially expressed mRNAs and lncRNAs in HepG2 cells treated with peptide 9R-P201. Biotechnol Lett 39(11):1639–1647. https://doi.org/10.1007/s10529-017-2407-1

Article  CAS  PubMed  Google Scholar 

Madhi H, Lee J, Choi YE, Li Y, Kim MH, Choi Y, Goh S (2022) FOXM1 inhibition enhances the therapeutic outcome of Lung Cancer Immunotherapy by modulating PD-L1 expression and cell proliferation. Adv Sci (Weinh) 9(29):2202702. https://doi.org/10.1002/advs.202202702

Article  CAS  PubMed  Google Scholar 

Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A, Vučković A-M, Bosello Travain V, Zaccarin M, Zennaro L et al (2019) Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biol 28:101328. https://doi.org/10.1016/j.redox.2019.101328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nandi D, Cheema PS, Jaiswal N, Nag A (2018) FoxM1: repurposing an oncogene as a biomarker. Semin Cancer Biol 52(Pt 1):74–84. https://doi.org/10.1016/j.semcancer.2017.08.009

Article  CAS  PubMed  Google Scholar 

Ouyang S, Li H, Lou L, Huang Q, Zhang Z, Mo J, Li M, Lu J, Zhu K, Chu Y et al (2022) Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol 52:102317. https://doi.org/10.1016/j.redox.2022.102317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng M, Hu Q, Wu Z, Wang B, Wang C, Yu F (2023) Mutation of tp53 confers ferroptosis resistance in lung cancer through the foxm1/mef2c axis. Am J Pathol 193(10):1587–1602. https://doi.org/10.1016/j.ajpath.2023.05.003

Article  CAS  PubMed  Google Scholar 

Qin Y, Pei Z, Feng Z, Lin P, Wang S, Li Y, Huo F, Wang Q, Wang Z, Chen Z-N et al (2021) Oncogenic activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated lipid peroxidation Accumulation. Front Cell Dev Biol 9:751593. https://doi.org/10.3389/fcell.2021.751593

Article  PubMed  PubMed Central  Google Scholar 

Radhakrishnan SK, Gartel AL (2008) FOXM1: the Achilles’ heel of cancer? Nat Rev Cancer 8(3). https://doi.org/10.1038/nrc2223-c1. c1; author reply c2

Raghuwanshi S, Gartel AL (2023) Small-molecule inhibitors targeting FOXM1: current challenges and future perspectives in cancer treatments. Biochim Biophys Acta Rev Cancer 1878(6):189015. https://doi.org/10.1016/j.bbcan.2023.189015

Article  CAS  PubMed  Google Scholar 

Triska M, Ivliev A, Nikolsky Y, Tatarinova TV (2017) Analysis of cis-Regulatory elements in gene co-expression networks in Cancer. Methods Mol Biol 1613:291–310. https://doi.org/10.1007/978-1-4939-7027-8_11

Article  CAS  PubMed  Google Scholar 

van Dam S, Võsa U, van der Graaf A, Franke L, de Magalhães JP (2017) Gene co-expression analysis for functional classification and gene–disease predictions. Brief Bioinform 19(4):575–592. https://doi.org/10.1093/bib/bbw139

Article  CAS  PubMed Central  Google Scholar 

Vasaikar SV, Straub P, Wang J, Zhang B (2018) LinkedOmics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res 46(D1):D956–D963. https://doi.org/10.1093/nar/gkx1090

Article  CAS  PubMed  Google Scholar 

Wang Y, Wu X, Ren Z, Li Y, Zou W, Chen J, Wang H (2023) Overcoming cancer chemotherapy resistance by the induction of ferroptosis. Drug Resist Updat 66:100916. https://doi.org/10.1016/j.drup.2022.100916

Article  CAS  PubMed  Google Scholar 

Wei G, Yang X, Lu H, Zhang L, Wei Y, Li H, Zhu M, Zhou X (2022) Prognostic value and immunological role of FOXM1 in human solid tumors. Aging 14(22):9128–9148. https://doi.org/10.18632/aging.204394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia Y, Liu S, Li C, Ai Z, Shen W, Ren W, Yang X (2020) Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo. Cell Death Dis 11(11):988. https://doi.org/10.1038/s41419-020-03194-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D (2016) Ferroptosis: process and function. Cell Death Differ 23(3):369–379. https://doi.org/10.1038/cdd.2015.158

Article  CAS 

留言 (0)

沒有登入
gif