Neuroinflammation is associated with Alzheimer’s disease co-pathology in dementia with Lewy bodies

Cunningham EL, McGuinness B, Herron B, Passmore AP (2015) Dementia. Ulster Med J 84(2):79–87

CAS  PubMed  PubMed Central  Google Scholar 

Lane CA, Hardy J, Schott JM (2018) Alzheimer’s disease. Eur J Neurol 25(1):59–70. https://doi.org/10.1111/ene.13439

Article  CAS  PubMed  Google Scholar 

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Kosaka K (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology 89(1):88–100. https://doi.org/10.1212/wnl.0000000000004058

Article  PubMed  PubMed Central  Google Scholar 

Walker L, McAleese KE, Thomas AJ, Johnson M, Martin-Ruiz C, Parker C, Attems J (2015) Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes. Acta Neuropathol 129(5):729–748. https://doi.org/10.1007/s00401-015-1406-3

Article  CAS  PubMed  Google Scholar 

Geut H, Vergouw LJM, Galis Y, Ingrassia A, de Jong FJ, Quadri M, van de Berg WDJ (2019) Neuropathological and genetic characteristics of a post-mortem series of cases with dementia with Lewy bodies clinically suspected of Creutzfeldt-Jakob’s disease. Parkinsonism Relat Disord 63:162–168. https://doi.org/10.1016/j.parkreldis.2019.02.011

Article  CAS  PubMed  Google Scholar 

Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112(4):389–404. https://doi.org/10.1007/s00401-006-0127-z

Article  PubMed  PubMed Central  Google Scholar 

Thal DR, Rüb U, Orantes M, Braak H (2002) Phases of a beta-deposition in the human brain and its relevance for the development of AD. Neurology 58(12):1791–1800. https://doi.org/10.1212/wnl.58.12.1791

Article  PubMed  Google Scholar 

Jellinger KA, Wenning GK, Seppi K (2007) Predictors of survival in dementia with lewy bodies and Parkinson dementia. Neurodegener Dis 4(6):428–430. https://doi.org/10.1159/000107703

Article  PubMed  Google Scholar 

Halliday GM, Holton JL, Revesz T, Dickson DW (2011) Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 122(2):187–204. https://doi.org/10.1007/s00401-011-0852-9

Article  CAS  PubMed  Google Scholar 

Irwin DJ, Hurtig HI (2018) The contribution of tau, amyloid-Beta and alpha-Synuclein Pathology to Dementia in Lewy Body Disorders. J Alzheimers Dis Parkinsonism 8(4). https://doi.org/10.4172/2161-0460.1000444

Sorrentino ZA, Giasson BI, Chakrabarty P (2019) α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease. Acta Neuropathol 138(1):1–21. https://doi.org/10.1007/s00401-019-01977-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nelson PT, Abner EL, Patel E, Anderson S, Wilcock DM, Kryscio RJ, Cykowski MD (2018) The Amygdala as a locus of pathologic misfolding in neurodegenerative diseases. J Neuropathol Exp Neurol 77(1):2–20. https://doi.org/10.1093/jnen/nlx099

Article  CAS  PubMed  Google Scholar 

Peng C, Trojanowski JQ, Lee VM (2020) Protein transmission in neurodegenerative disease. Nat Rev Neurol 16(4):199–212. https://doi.org/10.1038/s41582-020-0333-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vasili E, Dominguez-Meijide A, Outeiro TF (2019) Spreading of α-Synuclein and tau: a systematic comparison of the mechanisms involved. Front Mol Neurosci 12:107. https://doi.org/10.3389/fnmol.2019.00107

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moussaud S, Jones DR, Moussaud-Lamodière EL, Delenclos M, Ross OA, McLean PJ (2014) Alpha-synuclein and tau: teammates in neurodegeneration? Mol Neurodegener 9:43. https://doi.org/10.1186/1750-1326-9-43

Article  PubMed  PubMed Central  Google Scholar 

Marsh SE, Blurton-Jones M (2012) Examining the mechanisms that link β-amyloid and α-synuclein pathologies. Alzheimers Res Ther 4(2):11. https://doi.org/10.1186/alzrt109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, McKeith I (2019) Dementia with Lewy bodies: an update and outlook. Mol Neurodegener 14(1):5. https://doi.org/10.1186/s13024-019-0306-8

Article  PubMed  PubMed Central  Google Scholar 

Lemstra AW, de Beer MH, Teunissen CE, Schreuder C, Scheltens P, van der Flier WM, Sikkes SA (2017) Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 88(2):113–118. https://doi.org/10.1136/jnnp-2016-313775

Article  CAS  PubMed  Google Scholar 

Ferman TJ, Aoki N, Boeve BF, Aakre JA, Kantarci K, Graff-Radford J, Dickson DW (2020) Subtypes of dementia with Lewy bodies are associated with alpha-synuclein and tau distribution. Neurology 95(2):e155–e165. https://doi.org/10.1212/WNL.0000000000009763

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferreira D, Przybelski SA, Lesnick TG, Lemstra AW, Londos E, Blanc F, Kantarci K (2020) β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies. Neurology 95(24):e3257–e3268. https://doi.org/10.1212/wnl.0000000000010943

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fixemer S, Ameli C, Hammer G, Salamanca L, Uriarte Huarte O, Schwartz C, Bouvier DS (2022) Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies. Acta Neuropathol Commun 10(1):36. https://doi.org/10.1186/s40478-022-01342-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baik SH, Kang S, Son SM, Mook-Jung I (2016) Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer’s disease mouse model. Glia 64(12):2274–2290. https://doi.org/10.1002/glia.23074

Article  PubMed  Google Scholar 

Guzman-Martinez L, Maccioni RB, Andrade V, Navarrete LP, Pastor MG, Ramos-Escobar N (2019) Neuroinflammation as a common feature of neurodegenerative disorders. Front Pharmacol 10:1008. https://doi.org/10.3389/fphar.2019.01008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, Stefanova N (2013) Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia 61(3):349–360. https://doi.org/10.1002/glia.22437

Article  PubMed  PubMed Central  Google Scholar 

Heneka MT, Carson MJ, Khoury E, Landreth J, Brosseron GE, Feinstein F, Kummer DL, M. P (2015) Neuroinflammation in Alzheimer’s disease. Lancet Neurol 14(4):388–405. https://doi.org/10.1016/s1474-4422(15)70016-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kouli A, Camacho M, Allinson K, Williams-Gray CH (2020) Neuroinflammation and protein pathology in Parkinson’s disease dementia. Acta Neuropathol Commun 8(1):211. https://doi.org/10.1186/s40478-020-01083-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imamura K, Hishikawa N, Sawada M, Nagatsu T, Yoshida M, Hashizume Y (2003) Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson’s disease brains. Acta Neuropathol 106(6):518–526. https://doi.org/10.1007/s00401-003-0766-2

Article  CAS  PubMed  Google Scholar 

Doorn KJ, Moors T, Drukarch B, van de Berg W, Lucassen PJ, van Dam AM (2014) Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients. Acta Neuropathol Commun 2:90. https://doi.org/10.1186/s40478-014-0090-1

Article  PubMed  PubMed Central  Google Scholar 

Mackenzie IR (2000) Activated microglia in dementia with Lewy bodies. Neurology 55(1):132–134. https://doi.org/10.1212/wnl.55.1.132

Article  CAS  PubMed  Google Scholar 

Streit WJ, Xue QS (2016) Microglia in dementia with Lewy bodies. Brain Behav Immun 55:191–201. https://doi.org/10.1016/j.bbi.2015.10.012

Article  CAS  PubMed  Google Scholar 

Bachstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro ET, Webster SJ, Nelson PT (2015) Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta Neuropathol Commun 3:32. https://doi.org/10.1186/s40478-015-0209-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amin J, Holmes C, Dorey RB, Tommasino E, Casal YR, Williams DM, Boche D (2020) Neuroinflammation in dementia with Lewy bodies: a human post-mortem study. Transl Psychiatry 10(1):267. https://doi.org/10.1038/s41398-020-00954-8

Article  CAS  PubMed 

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