*Department of Internal Medicine, ASST Sette Laghi, Varese, Italy;

†VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA;

‡Department of Medicine and Surgery, University of Insubria, Varese, Italy; and

§Robert M. Berne Cardiovascular Research Center and Division of Cardiology, Department of Internal Medicine, Heart and Vascular Center, University of Virginia, Charlottesville, VA.

Correspondence: Alessandra Vecchié, MD, Medicina Generale 1, Medical Center, Department of Internal Medicine, Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi, Varese, Italy (e-mail: [email protected]).

A. Vecchié, A. Bonaventura, and A. Abbate received honoraria from Effetti s.r.l. (Milan, Italy) to collaborate on the medical web site www.inflammology.org in the past 36 months, outside the present work. A. Abbate reports grants and personal fees from Kiniksa Pharmaceuticals and personal fees from Novo-Nordisk and Implicit Biosciences outside the submitted work.