*Department of Cardiology, Affiliated Hospital and Institute of Cardiovascular Diseases, Jiangsu University, Zhenjiang, China; and

†Department of Basic Medical Sciences, School of Nursing, Zhenjiang College, Zhenjiang, China.

Correspondence: Zhongqun Wang, PhD, Department of Cardiology, Affiliated Hospital and Institute of Cardiovascular Diseases, Jiangsu University, Zhenjiang 212001, China (e-mail: [email protected]).

This work was supported as follows: the National Natural Science Foundation of China (81970379); Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX22_3712); Science and Technology Support Program of Jiangsu Province (SH2022067).

The authors report no conflicts of interest.

The authors declare that all data were generated in-house and that no paper mill was used. Z. Wang conceived the experimental design. All authors performed experiments. G. Zang and Y. Chen analyzed data. G. Zang drafted the manuscript. G. Guo prepared figures. A. Wan and B. Li edited and revised the manuscript. All authors read and approved the final version of the manuscript.

All protocols in this study were approved by the Experimental Animal Use Ethics Committee of Jiangsu University, Jiangsu, China, in compliance with Directive 2010/63/EU guidelines.