*Department of Anatomy and Embryology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands;

†Department of Pathology, School of Medicine, University of Mississippi Medical Center, Jackson, MS;

‡School of Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands;

§Department of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy;

¶Mediterranea Cardiocentro, Napoli, Italy; and

‖Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS.

Correspondence: Raffaele Altara, PhD, Department of Anatomy and Embryology, Faculty of Health, Medicine and Life Sciences, Minderbroedersberg 4-6, Maastricht, the Netherlands 6211 LK (e-mail: [email protected]).

G. W. Booz was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM121334. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

G. Biondi-Zoccai has consulted for Amarin, Balmed, Cardionovum, Crannmedical, Endocore Lab, Eukon, Guidotti, Innovheart, Meditrial, Microport, Opsens Medical, Terumo, and Translumina, outside the present work. The remaining authors report no conflict of interest.