*Department of Pharmacology, Basic Medical Sciences Center, Shanxi Medical University, Taiyuan, Shanxi, China; and

†Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi, China.

Correspondence: Cai-hong Yang, PhD or Yan-ying Fan, PhD, Department of Pharmacology, Basic Medical Sciences Center, Shanxi Medical University, Taiyuan, Shanxi, China (e-mail: [email protected] or [email protected]) or Xiang-ying Jiao, PhD, Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi, China (e-mail: [email protected]).

The authors report no conflicts of interest.

All data generated or analyzed during this study are included in this published article.

All animal procedures were approved by the Institutional Animal Care and Use Committee of Shanxi Medical University and conformed to the National Institutes of Health Guide for the Care and Use of Laboratory Animals.

C. Yang and H. Qiu contributed equally to this work.

C.-h. Yang and Y.-y. Fan conducted the experiments and analyzed the data. C.-h. Yang and H.-q. Qiu prepared the manuscript. H.-q. Qiu prepared the reagents. C. Wang and C.-r. Zhang performed the animal experiments. Y.-t. Tang contributed the analytical tools used. C.-h. Yang, Y.-y. Fan, and X.-y. Jiao conceived, designed, and supervised the study and revised the manuscript.