Hophing L, Kyriakopoulos P, Bui E. Sex and gender differences in epilepsy. Int Rev Neurobiol. 2022;164:235–76. https://doi.org/10.1016/bs.irn.2022.06.012.

Article  CAS  PubMed  Google Scholar 

Cepeda MS, Teneralli RE, Kern DM, Novak G. Differences between men and women in response to antiseizure medication use and the likelihood of developing treatment resistant epilepsy. Epilepsia Open. 2022;7:598–607. https://doi.org/10.1002/epi4.12632.

Article  PubMed  PubMed Central  Google Scholar 

Alfares I, Javaid MS, Chen Z, Anderson A, Antonic-Baker A, Kwan P. Sex Differences in the risk of cutaneous adverse drug reactions induced by antiseizure medications: a systematic review and meta-analysis. CNS Drugs. 2021;35:161–76. https://doi.org/10.1007/s40263-021-00794-0.

Article  PubMed  Google Scholar 

Giuliano L, Vecchio C, Mastrangelo V, Durante V, Zambrelli E, Cantalupo G, et al. Sex differences in side effects of antiseizure medications in pediatric patients with epilepsy: a systematic review. Seizure. 2022;102:6–13. https://doi.org/10.1016/j.seizure.2022.09.013.

Article  PubMed  Google Scholar 

Wong IC, Mawer GE, Sander JW. Factors influencing the incidence of lamotrigine-related skin rash. Ann Pharmacother. 1999;33:1037–42. https://doi.org/10.1345/aph.18422.

Article  CAS  PubMed  Google Scholar 

Arif H, Buchsbaum R, Weintraub D, Koyfman S, Salas-Humara C, Bazil CW, et al. Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology. 2007;68:1701–9. https://doi.org/10.1212/01.wnl.0000261917.83337.db.

Article  CAS  PubMed  Google Scholar 

Alvestad S, Lydersen S, Brodtkorb E. Cross-reactivity pattern of rash from current aromatic antiepileptic drugs. Epilepsy Res. 2008;80:194–200. https://doi.org/10.1016/j.eplepsyres.2008.04.003.

Article  CAS  PubMed  Google Scholar 

Alvestad S, Lydersen S, Brodtkorb E. Rash from antiepileptic drugs: influence by gender, age, and learning disability. Epilepsia. 2007;48:1360–5. https://doi.org/10.1111/j.1528-1167.2007.01109.x.

Article  CAS  PubMed  Google Scholar 

Wang X, Lang S, Shi X, Tian H, Wang R, Yang F. Antiepileptic drug-induced skin reactions: a retrospective study and analysis in 3793 Chinese patients with epilepsy. Clin Neurol Neurosurg. 2012;114:862–5. https://doi.org/10.1016/j.clineuro.2012.01.019.

Article  PubMed  Google Scholar 

Wang X-Q, Shi X-B, Au R, Chen F-S, Wang F, Lang S-Y. Influence of chemical structure on skin reactions induced by antiepileptic drugs—the role of the aromatic ring. Epilepsy Res. 2011;94:213–7. https://doi.org/10.1016/j.eplepsyres.2011.02.005.

Article  CAS  PubMed  Google Scholar 

Shirzadi M, Alvestad S, Hovdal H, Espeset K, Lydersen S, Brodtkorb E. Comparison of carbamazepine rash in multiple sclerosis and epilepsy. Acta Neurol Scand. 2012;125:60–3. https://doi.org/10.1111/j.1600-0404.2011.01553.x.

Article  CAS  PubMed  Google Scholar 

Błaszczyk B, Szpringer M, Czuczwar SJ, Lasoń W. Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions. Pharmacol Rep PR. 2013;65:399–409. https://doi.org/10.1016/s1734-1140(13)71015-6.

Article  PubMed  Google Scholar 

Andersen P, Moseklide L. Immunoglobulin levels and autoantibodies in epileptics on long-term anticonvulsant therapy. Acta Med Scand. 1977;201:69–74. https://doi.org/10.1111/j.0954-6820.1977.tb15657.x.

Article  CAS  PubMed  Google Scholar 

Nasreddine W, Beydoun A. Valproate-induced thrombocytopenia: a prospective monotherapy study. Epilepsia. 2008;49:438–45. https://doi.org/10.1111/j.1528-1167.2007.01429.x.

Article  CAS  PubMed  Google Scholar 

Bachmann T, Bertheussen KH, Svalheim S, Rauchenzauner M, Luef G, Gjerstad L, et al. Haematological side effects of antiepileptic drug treatment in patients with epilepsy. Acta Neurol Scand Suppl. 2011. https://doi.org/10.1111/j.1600-0404.2011.01539.x.

Article  PubMed  Google Scholar 

Barragry JM, Makin HL, Trafford DJ, Scott DF. Effect of anticonvulsants on plasma testosterone and sex hormone binding globulin levels. J Neurol Neurosurg Psychiatry. 1978;41:913–4. https://doi.org/10.1136/jnnp.41.10.913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonuccelli U, Murialdo G, Rossi G, Bonura ML, Polleri A, Murri L. Prolactin secretion in epileptic subjects treated with phenobarbital: sex differences and circadian periodicity. Epilepsia. 1986;27:142–8. https://doi.org/10.1111/j.1528-1157.1986.tb03517.x.

Article  CAS  PubMed  Google Scholar 

Stoffel-Wagner B, Bauer J, Flügel D, Brennemann W, Klingmüller D, Elger CE. Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication. Epilepsia. 1998;39:1164–73. https://doi.org/10.1111/j.1528-1157.1998.tb01307.x.

Article  CAS  PubMed  Google Scholar 

Rättyä J, Pakarinen AJ, Knip M, Repo-Outakoski M, Myllylä VV, Isojärvi JI. Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. Neurology. 2001;57:440–4. https://doi.org/10.1212/wnl.57.3.440.

Article  PubMed  Google Scholar 

Lossius MI, Taubøll E, Mowinckel P, Mørkrid L, Gjerstad L. Reversible effects of antiepileptic drugs on reproductive endocrine function in men and women with epilepsy—a prospective randomized double-blind withdrawal study. Epilepsia. 2007;48:1875–82. https://doi.org/10.1111/j.1528-1167.2007.01147.x.

Article  PubMed  Google Scholar 

Lossius MI, Taubøll E, Mowinckel P, Gjerstad L. Reversible effects of antiepileptic drugs on thyroid hormones in men and women with epilepsy: a prospective randomized double-blind withdrawal study. Epilepsy Behav EB. 2009;16:64–8. https://doi.org/10.1016/j.yebeh.2009.07.014.

Article  Google Scholar 

Hufnagel A, Kowalik A, Rettig K, Schreiner A, Schäuble B, TOP-GER-11 Investigators. Long-term assessment of topiramate for epilepsy: an open-label, single-arm, multicentre, prospective study in a naturalistic setting. Clin Drug Investig. 2011;31:779–90. https://doi.org/10.2165/11593850-000000000-00000.

Article  CAS  PubMed  Google Scholar 

Shih F-Y, Chuang Y-C, Chuang M-J, Lu Y-T, Tsai W-C, Fu T-Y, et al. Effects of antiepileptic drugs on thyroid hormone function in epilepsy patients. Seizure. 2017;48:7–10. https://doi.org/10.1016/j.seizure.2017.03.011.

Article  PubMed  Google Scholar 

Einarsdottir MJ, Olafsson E, Sigurjonsdottir HA. Antiepileptic drugs are associated with central hypothyroidism. Acta Neurol Scand. 2019;139:64–9. https://doi.org/10.1111/ane.13026.

Article  CAS  PubMed  Google Scholar 

Gough H, Goggin T, Crowley M, Callaghan N. Serum bilirubin levels with antiepileptic drugs. Epilepsia. 1989;30:597–602. https://doi.org/10.1111/j.1528-1157.1989.tb05478.x.

Article  CAS  PubMed  Google Scholar 

Yamamoto Y, Takahashi Y, Suzuki E, Mishima N, Inoue K, Itoh K, et al. Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. Epilepsy Res. 2012;101:202–9. https://doi.org/10.1016/j.eplepsyres.2012.04.001.

Article  CAS  PubMed  Google Scholar 

Tseng Y-L, Huang C-R, Lin C-H, Lu Y-T, Lu C-H, Chen N-C, et al. Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy. Medicine (Baltimore). 2014;93: e66. https://doi.org/10.1097/MD.0000000000000066.

Article  CAS  PubMed  Google Scholar 

Miyamoto T, Kohsaka M, Koyama T. Psychotic episodes during zonisamide treatment. Seizure. 2000;9:65–70. https://doi.org/10.1053/seiz.1999.0368.

Article  CAS  PubMed  Google Scholar 

Machado RA, Espinosa AG, Melendrez D, González YR, García VF, Rodríguez YQ. Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy. Seizure. 2011;20:280–4. https://doi.org/10.1016/j.seizure.2010.12.010.

Article  PubMed  Google Scholar 

Helmstaedter C, Mihov Y, Toliat MR, Thiele H, Nuernberg P, Schoch S, et al. Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. Epilepsia. 2013;54:36–44. https://doi.org/10.1111/j.1528-1167.2012.03603.x.

Article  CAS  PubMed  Google Scholar 

Mula M, von Oertzen TJ, Cock HR, Yogarajah M, Lozsadi DA, Agrawal N. Fatigue during treatment with antiepileptic drugs: a levetiracetam-specific adverse event? Epilepsy Behav EB. 2017;72:17–21. https://doi.org/10.1016/j.yebeh.2017.04.030.

Article  Google Scholar 

Olusanya A, Ogunleye O, Godman B, Fadare J, Danesi M. Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications. J Comp Eff Res. 2017;6:33–42. https://doi.org/10.2217/cer-2016-0057.

Article  PubMed  Google Scholar 

Jokeit H, Krämer G, Ebner A. Do antiepileptic drugs accelerate forgetting? Epilepsy Behav EB. 2005;6:430–2. https://doi.org/10.1016/j.yebeh.2004.12.012.

Article  Google Scholar 

Martins HH, Alonso NB, Vidal-Dourado M, Carbonel TD, de Araújo Filho GM, Caboclo LO, et al. Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? The Portuguese-Brazilian validation of the Liverpool Adverse Events Profile. Epilepsy Behav EB. 2011;22:511–7. https://doi.org/10.1016/j.yebeh.2011.08.005.

Article  CAS