The Effect of Levetiracetam Compared with Enzyme-Inducing Antiseizure Medications on Apixaban and Rivaroxaban Peak Plasma Concentrations

Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, et al. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol. 2018;17:530–8.

Article  CAS  PubMed  Google Scholar 

Nevitt SJ, Sudell M, Cividini S, Marson AG, Tudur SC. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Cochrane Database Syst Rev. 2022;14(4):CD011412.

Google Scholar 

US Food and Drug Administration. Keppra prescribing information. 2020. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021035s104,021505s044lbl.(pdf. Accessed 25 Jun 2023.

Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383:955–62.

Article  CAS  PubMed  Google Scholar 

Zeng S, Zheng Y, Jiang J, Ma J, Zhu W, Cai X. Effectiveness and safety of DOACs vs. warfarin in patients with atrial fibrillation and frailty: a systematic review and meta-analysis. Front Cardiovasc Med. 2022;9:907197.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perlman A, Wanounou M, Goldstein R, Choshen Cohen L, Singer DE, Muszkat M. Ischemic and thrombotic events associated with concomitant Xa-inhibiting direct oral anticoagulants and antiepileptic drugs: analysis of the FDA Adverse Event Reporting System (FAERS). CNS Drugs. 2019;33:1223–8.

Article  CAS  PubMed  Google Scholar 

Perlman A, Goldstein R, Choshen Cohen L, Hirsh-Raccah B, Hakimian D, Matok I, et al. Effect of enzyme-inducing antiseizure medications on the risk of sub-therapeutic concentrations of direct oral anticoagulants: a retrospective cohort study. CNS Drugs. 2021;35:305–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gronich N, Stein N, Muszkat M. Association between use of pharmacokinetic-interacting drugs and effectiveness and safety of direct acting oral anticoagulants: nested case-control study. Clin Pharmacol Ther. 2021;110:1526–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ip BY, Ko H, Wong GL, Yip TC, Lau LH, Lau AY, et al. Thromboembolic risks with concurrent direct oral anticoagulants and antiseizure medications: a population-based analysis. CNS Drugs. 2022;36:1313–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen H, Mahajna G, Ben-Shushan T, Matok I, Eyal S. The extent of cytochrome P450 3A induction by antiseizure medications: a systematic review and network meta-analysis. Epilepsia. 2024;65:445–55.

Article  CAS  PubMed  Google Scholar 

Goldstein R, Jacobs AR, Zighan L, Gronich N, Bialer M, Muszkat M. Interactions between direct oral anticoagulants (DOACs) and antiseizure medications: potential implications on DOAC treatment. CNS Drugs. 2023;37:203–14.

Article  CAS  PubMed  Google Scholar 

Steffel J, Collins R, Antz M, Cornu P, Desteghe L, Haeusler KG, et al. 2021 European Heart Rhythm Association practical guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. EP Europace. 2021;23:1612–76.

Article  Google Scholar 

Lombardo L, Pellitteri R, Balazy M, Cardile V. Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs. Curr Neurovasc Res. 2008;5:82–92.

Article  CAS  PubMed  Google Scholar 

Moerman L, wyffels L, Slaets D, Raedt R, Boon P, De Vos F. Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with 11C-desmethylloperamide. Epilepsy Res. 2011;94:18–25.

Article  CAS  PubMed  Google Scholar 

Levy RH, Ragueneau-Majlessi I, Baltes E. Repeated administration of the novel antiepileptic agent levetiracetam does not alter digoxin pharmacokinetics and pharmacodynamics in healthy volunteers. Epilepsy Res. 2001;46:93–9.

Article  CAS  PubMed  Google Scholar 

Abou Kaoud M, Nissan R, Segev A, Sabbag A, Orion D, Maor E. Levetiracetam interaction with direct oral anticoagulants: a pharmacovigilance study. CNS Drugs. 2023;37:1111–21.

Article  CAS  PubMed  Google Scholar 

Perlman A, Horwitz E, Hirsh-Raccah B, Aldouby-Bier G, Fisher Negev T, Hochberg-Klein S, et al. Clinical pharmacist led hospital-wide direct oral anticoagulant stewardship program. Isr J Health Policy Res. 2019;8:19.

Article  PubMed  PubMed Central  Google Scholar 

Gosselin RC, Funk (Adcock) DM, Taylor JM, Francart SJ, Hawes EM, Friedman KD, et al. Comparison of anti-Xa and dilute Russell viper venom time assays in quantifying drug levels in patients on therapeutic doses of rivaroxaban. Arch Pathol Lab Med. 2014;138:1680–4.

Article  PubMed  Google Scholar 

Becker RC, Yang H, Barrett Y, Mohan P, Wang J, Wallentin L, et al. Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban: an oral, direct and selective factor Xa inhibitor. J Thromb Thrombolysis. 2011;32:183–7.

Article  PubMed  Google Scholar 

Eikelboom JW, Quinlan DJ, Hirsh J, Connolly SJ, Weitz JI. Laboratory monitoring of non-vitamin K antagonist oral anticoagulant use in patients with atrial fibrillation: a review. JAMA Cardiol. 2017;2:566.

Article  PubMed  Google Scholar 

Gosselin R, Adcock D, Bates S, Douxfils J, Favaloro E, Gouin-Thibault I, et al. International Council for Standardization in Haematology (ICSH) recommendations for laboratory measurement of direct oral anticoagulants. Thromb Haemost. 2018;118:437–50.

Article  PubMed  Google Scholar 

DrugBank. Cytochrome P-450 CYP3A4 inducers. Available from: https://www.drugbank.ca/categories/DBCAT003896. Accessed 9 Jun 2020.

US Food and Drug Administration. For healthcare professionals: FDA’s examples of drugs that interact with CYP enzymes and transporter systems. 2023. Available from: https://www.fda.gov/drugs/drug-interactions-labeling/healthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems. Accessed 5 Mar 2024.

Raval AN, Cigarroa JE, Chung MK, Diaz-Sandoval LJ, Diercks D, Piccini JP, et al. Management of patients on non-vitamin K antagonist oral anticoagulants in the acute care and periprocedural setting: a scientific statement from the American Heart Association. Circulation. 2017;135:e604–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mangiardi M, Iaccarino G, Alessiani M, Bonura A, Anticoli S. Treating post-stroke epilepsy in a patient with multiple comorbidities. Cureus. 2023;15: e38483.

PubMed  PubMed Central  Google Scholar 

Brigo F, Lattanzi S, Zelano J, Bragazzi NL, Belcastro V, Nardone R, et al. Randomized controlled trials of antiepileptic drugs for the treatment of post-stroke seizures: a systematic review with network meta-analysis. Seizure. 2018;61:57–62.

Article  CAS  PubMed  Google Scholar 

Werhahn KJ, Trinka E, Dobesberger J, Unterberger I, Baum P, Deckert-Schmitz M, et al. A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy. Epilepsia. 2015;56:450–9.

Article  CAS  PubMed  Google Scholar 

Paciullo F, Costa C, Gresele P. Rivaroxaban plasma levels and levetiracetam: a case report. Ann Intern Med. 2020;173:71–2.

Article  PubMed  Google Scholar 

Mavri A, Ilc S. The efficacy of direct oral anticoagulants in patients on concomitant treatment with levetiracetam. Sci Rep. 2023;13:9257.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranzato F, Roberti R, Deluca C, Carta M, Peretti A, Polo D, et al. Pilot study on the probability of drug-drug interactions among direct oral anticoagulants (DOACs) and antiseizure medications (ASMs): a clinical perspective. Neurol Sci. 2024;45:277–88.

Article  PubMed  Google Scholar 

Grymonprez M, Carnoy L, Capiau A, Boussery K, Mehuys E, De Backer TL, et al. Impact of P-glycoprotein and CYP3A4-interacting drugs on clinical outcomes in patients with atrial fibrillation using non-vitamin K antagonist oral anticoagulants: a nationwide cohort study. Eu Heart J Cardiovasc Pharmacother. 2023;9:722–30.

Article  Google Scholar 

Giustozzi M, Mazzetti M, Paciaroni M, Agnelli G, Becattini C, Vedovati MC. Concomitant use of direct oral anticoagulants and antiepileptic drugs: a prospective cohort study in patients with atrial fibrillation. Clin Drug Investig. 2021;41:43–51.

Article  CAS  PubMed  Google Scholar 

Wang C-L, Wu VC-C, Chang K-H, Tu H-T, Kuo C-F, Huang Y-T, et al. Assessing major bleeding risk in atrial fibrillation patients concurrently taking non-vitamin K antagonist oral anticoagulants and antiepileptic drugs. Eur Heart J Cardiovasc Pharmacother. 2020;6:147–54.

Article  PubMed  Google Scholar 

Giner-Soriano M, Marsal JR, Gomez-Lumbreras A, Morros R. Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia. BMC Neurol. 2021;21:208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang C-S, Liao C-H, Lin C-C, Lane H-Y, Sung F-C, Kao C-H. Patients with epilepsy are at an increased risk of subsequent stroke: a population-based cohort study. Seizure. 2014;23:377–81.

Article  PubMed  Google Scholar 

Renoux C, Dell’Aniello S, Saarela O, Filion KB, Boivin J-F. Antiepileptic drugs and the risk of ischaemic stroke and myocardial infarction: a population-based cohort study. BMJ Open. 2015;5: e008365.

Article  PubMed  PubMed Central  Google Scholar 

Redfors P, Holmegaard L, Pedersen A, Jern C, Malmgren K. Long-term follow-up of post-stroke epilepsy after ischemic stroke: room for improved epilepsy treatment. Seizure. 2020;76:50–5.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif