Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway

Harris AJ, Mirchandani AS, Lynch RW, Murphy F, Delaney L, Small D, et al. IL4Ralpha Signaling abrogates hypoxic neutrophil survival and limits Acute Lung Injury responses in vivo. Am J Respir Crit Care Med. 2019;200:235–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long ME, Mallampalli RK, Horowitz JC. Pathogenesis of pneumonia and acute lung injury. Clin Sci (Lond). 2022;136:747–69.

Article  CAS  PubMed  Google Scholar 

Butt Y, Kurdowska A, Allen TC. Acute Lung InjuryA Clinical and Molecular Review. Arch Pathol Lab Med. 2016;140:345–50.

Article  CAS  PubMed  Google Scholar 

Aegerter H, Kulikauskaite J, Crotta S, Patel H, Kelly G, Hessel EM, et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol. 2020;21:145–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan J, Wang A, Cao J, Chen L. Apelin/APJ system: an emerging therapeutic target for respiratory diseases. Cell Mol Life Sci. 2020;77:2919–30.

Article  CAS  PubMed  Google Scholar 

Rohde K, Keller M, la Cour Poulsen L, Ronningen T, Stumvoll M, Tonjes A, et al. (Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution. EBioMedicine. 2019;44:476–88.

Article  PubMed  PubMed Central  Google Scholar 

Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med. 2008;14:1112–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng L, Chen S, Shi G, He S, Wang Z, Shen J, et al. Use of single cell transcriptomic techniques to study the role of high-risk human papillomavirus infection in Cervical Cancer. Front Immunol. 2022;13:907599.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ni W, Chen Z, Zhou X, Yang R, Yu M, Lu J, et al. Targeting notch and EGFR signaling in human mucoepidermoid carcinoma. Signal Transduct Target Ther. 2021;6:27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhaskar PT, Hay N. The two TORCs and Akt. Dev Cell. 2007;12:487–502.

Article  CAS  PubMed  Google Scholar 

B J, MANNICK1, MORRIS1 M, P. HH-U. TORC1 inhibition enhances immune function and reduces infections in the elderly [J]. Sci Transl Med,. 2018;eaaq1564 (2018).

Bartel S, Schulz N, Alessandrini F, Schamberger AC, Pagel P, Theis FJ, et al. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma. Sci Rep. 2017;7:46026.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Y, Lv J, Fang Y, Luo Q, He Y, Li L, et al. Crtc1 Deficiency causes obesity potentially via regulating PPARgamma Pathway in White Adipose. Front Cell Dev Biol. 2021;9:602529.

Article  PubMed  PubMed Central  Google Scholar 

Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4:31–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan XT, He XH, Wang YL, Zhang ZZ, Tang JJ. Transduced PEP-1-Heme Oxygenase-1 Fusion protein attenuates Lung Injury in septic shock rats. Oxid Med Cell Longev. 2018;2018:6403861.

Article  PubMed  PubMed Central  Google Scholar 

Xie W, Lu Q, Wang K, Lu J, Gu X, Zhu D, et al. miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin. J Cell Physiol. 2018;233:6615–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grivennikov1 SI, Greten FR, Karin M. Immunity, inflammation, and Cancer. Cell 2021;2010 March 19; 140(6):883–99.

Yang X, Zhao T, Feng L, Shi Y, Jiang J, Liang S, et al. PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway. Environ Int. 2019;127:601–14.

Article  CAS  PubMed  Google Scholar 

Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, et al. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiology-Lung Cell Mol Physiol. 2022;322:L550–63.

Article  CAS  Google Scholar 

Becker E, Husain M, Bone N, Smith S, Morris P, Zmijewski JW. AMPK activation improves recovery from pneumonia-induced lung injury via reduction of Er-stress and apoptosis in alveolar epithelial cells. Respir Res. 2023;24.

Lama TYW, Teea JH, Shanmugasundarama NN. M, Chee Bing Ongd MZH. ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis. PNAS. 2022;Vol. 119 No. 4 e2019161119:1–11.

Martin TR, Hagimoto N, Nakamura M, Matute-Bello G. Apoptosis and epithelial injury in the lungs. Proc Am Thorac Soc. 2005;2:214–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sauler M, Bazan IS, Lee PJ. Cell death in the lung: the apoptosis–necroptosis Axis. Annu Rev Physiol. 2019;81:375–402.

Article  CAS  PubMed  Google Scholar 

Li X, Jamal M, Guo P, Jin Z, Zheng F, Song X, et al. Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways. Biomed Pharmacother. 2019;118:109363.

Article  CAS  PubMed  Google Scholar 

Vishwakarma J, Gupta K, Mishra J, Garg A, Malik R, Kashyap A et al. Hypothyroidism induces motor deficit via altered cerebellar HB-EGF/EGFR and autophagy. J Endocrinol. 2023;257.

Bai X, Zheng E, Tong L, Liu Y, Li X, Yang H et al. Angong Niuhuang Wan inhibit ferroptosis on ischemic and hemorrhagic stroke by activating PPARγ/AKT/GPX4 pathway. J Ethnopharmacol. 2024;321.

El-Maadawy WH, Hassan M, Abdou RM, El-Dine RS, Aboushousha T, El-Tanbouly ND et al. 6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways. Environ Toxicol Pharmacol. 2022;91.

Ali FF, Mohammed MM, Hussein Y, Ibrahim MFG. Targeting PI3K/p-Akt/eNOS, Nrf2/HO‐1, and NF‐κB/p53 signaling pathways by angiotensin 1–7 protects against liver injury induced by ischemia–reperfusion in rats. Cell Biochem Funct. 2024;42.

Yan J, Li J, Zhang L, Sun Y, Jiang J, Huang Y, et al. Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling. Free Radic Biol Med. 2018;121:78–85.

Article  CAS  PubMed  Google Scholar 

Mizuta Y, Akahoshi T, Guo J, Zhang S, Narahara S, Kawano T, et al. Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells. Stem Cell Res Ther. 2020;11:508.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu H, Yin K, Su H, Wang D, Zhang Y, Hou L, et al. Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR. Environ Toxicol. 2023;38:78–89.

Article  CAS  PubMed  Google Scholar 

Wang Y, Yuan Y, Wang W, He Y, Zhong H, Zhou X, et al. Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking. Comput Biol Med. 2022;145:105454.

Article  CAS  PubMed  Google Scholar 

Abd El-Ghafar OAM, Hassanein EHM, Sayed AM, Rashwan EK, Shalkami AGS, Mahmoud AM. Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K /Akt/ mTOR and Nrf2 signaling in rats. Phytother Res. 2021;35:4499–510.

Article  CAS  PubMed  Google Scholar 

Zhang E, Wang J, Chen Q, Wang Z, Li D, Jiang N, et al. Artesunate ameliorates sepsis-induced acute lung injury by activating the mTOR/AKT/PI3K axis. Gene. 2020;759:144969.

Article  CAS  PubMed  Google Scholar 

Oishi H, Takano K-i, Tomita K, Takebe M, Yokoo H, Yamazaki M, et al. Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the akt pathway. Am J Physiology-Lung Cell Mol Physiol. 2012;303:L130–40.

Article  CAS  Google Scholar 

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