Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
Allemani C, Matsuda T, Di Carlo V, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023–75.
Article PubMed PubMed Central Google Scholar
Inadomi J, Alastal H, Bonavina L, et al. Recent advances in Barrett’s esophagus. Ann N Y Acad Sci. 2018;1434:227–38.
Zhang Y. Epidemiology of esophageal cancer. World J Gastroenterol. 2013;14:5598–606.
Huang FL, Yu SJ. Esophageal cancer: risk factors, genetic association, and treatment. Asian J Surg. 2018;41:210–5.
Abrams JA, Fields S, Lightdale CJ, et al. Racial and ethnic disparities in the prevalence of Barrett’s esophagus among patients who undergo upper endoscopy. Clin Gastroenterol Hepatol. 2008;6:30–4.
Drahos J, Ricker W, Parsons R, et al. Metabolic syndrome increases risk of Barrett esophagus in the absence of gastroesophageal reflux: an analysis of SEER-Medicare Data. J Clin Gastroenterol. 2015;49:282–8.
Article CAS PubMed PubMed Central Google Scholar
Drahos J, Ricker W, Pfeiffer RM, et al. Metabolic syndrome and risk of esophageal adenocarcinoma in elderly patients in the United States: an analysis of SEER-Medicare data. Cancer. 2017;123:657–65.
Engels EA, Pfeiffer RM, Ricker W, et al. Use of Surveillance, Epidemiology, and end results-Medicare Data to conduct case-control studies of cancer among the US elderly. Am J Epidemiol. 2011;174:860–70.
Article PubMed PubMed Central Google Scholar
Stocks T, Bjørge T, Ulmer H, et al. Metabolic risk score and cancer risk: pooled analysis of seven cohorts. Int J Epidemiol. 2015;44:1353–63.
Article PubMed PubMed Central Google Scholar
Thrift AP, Shaheen NJ, Gammon MD, et al. Obesity and risk of esophageal adenocarcinoma and Barrett’s esophagus: a mendelian randomization study. J Natl Cancer Inst. 2014;106:dju252.
Article PubMed PubMed Central Google Scholar
Xu B, Zhou X, Li X, et al. Diabetes mellitus carries a risk of esophageal cancer: a meta-analysis. Med (Baltim). 2017;96:e7944.
Iyer PG, Borah BJ, Heien HC, et al. Association of Barrett’s esophagus with type II diabetes Mellitus: results from a large population-based case-control study. Clin Gastroenterol Hepatol. 2013;11:1108–14.
Wang J, Zhuge J, Feng D, et al. Mendelian randomization study of circulating lipids and biliary tract cancer among East asians. BMC Cancer. 2022;22:273.
Article CAS PubMed PubMed Central Google Scholar
Nowak C, Ärnlöv J. A mendelian randomization study of the effects of blood lipids on breast cancer risk. Nat Commun. 2018;9:3957.
Article PubMed PubMed Central Google Scholar
Sako A, Kitayama J, Kaisaki S, et al. Hyperlipidemia is a risk factor for lymphatic metastasis in superficial esophageal carcinoma. Cancer Lett. 2004;208:43–9.
Article CAS PubMed Google Scholar
Xie SH, Rabbani S, Ness-Jensen E, et al. Circulating levels of inflammatory and metabolic biomarkers and risk of esophageal adenocarcinoma and Barrett Esophagus: systematic review and Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2020;29:2109–18.
Article CAS PubMed Google Scholar
Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318:1925–6.
Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014;23:R89–98.
Article CAS PubMed PubMed Central Google Scholar
Willer CJ, Schmidt EM, Sengupta S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013;45:1274–83.
Article CAS PubMed PubMed Central Google Scholar
Klimentidis YC, Arora A, Newell M, et al. Phenotypic and Genetic Characterization of Lower LDL Cholesterol and increased type 2 diabetes risk in the UK Biobank. Diabetes. 2020;69:2194–205.
Article CAS PubMed PubMed Central Google Scholar
Ong JS, An J, Han X, et al. Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis. Gut. 2022;71:1053–61.
Eusebi LH, Cirota GG, Zagari RM, et al. Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis. Gut. 2021;70(3):456–63.
Article CAS PubMed Google Scholar
Burgess S, Thompson SG. Multivariable mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol. 2015;181:251–60.
Cao H, Baranova A, Wei X et al. Bidirectional causal associations between type 2 diabetes and COVID-19. J Med Virol. 2022.
Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44:512–25.
Article PubMed PubMed Central Google Scholar
Verbanck M, Chen CY, Neale B, et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:693–8.
Article CAS PubMed PubMed Central Google Scholar
Bowden J, Del Greco MF, Minelli C, et al. Improving the accuracy of two-sample summary-data mendelian randomization: moving beyond the NOME assumption. Int J Epidemiol. 2019;48:728–42.
Palmer TM, Lawlor DA, Harbord RM, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res. 2012;21:223–42.
Article PubMed PubMed Central Google Scholar
Shim H, Chasman DI, Smith JD, et al. A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 caucasians. PLoS ONE. 2015;10:e0120758.
Article PubMed PubMed Central Google Scholar
Brion MJ, Shakhbazov K, Visscher PM. Calculating statistical power in mendelian randomization studies. Int J Epidemiol. 2013;42:1497–501.
Hennig B, Toborek M, McClain CJ. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll Nutr. 2001;20:97–105.
Article CAS PubMed Google Scholar
Huang MC, Graeler M, Shankar G, et al. Lysophospholipid mediators of immunity and neoplasia. Biochim Biophys Acta. 2002;1582:161–7.
Article CAS PubMed Google Scholar
Liu S, Jiang H, Min L, et al. Lysophosphatidic acid mediated PI3K/Akt activation contributed to esophageal squamous cell cancer progression. Carcinogenesis. 2021;42:611–20.
Article CAS PubMed Google Scholar
Baranova A, Song Y, Cao H, et al. Causal associations between basal metabolic rate and COVID-19. Diabetes. 2023;72:149–54.
留言 (0)