Pirastu N, Joshi PK, de Vries PS, Cornelis MC, McKeigue PM, Keum N, et al. GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. Nat Commun. 2017;8(1):1584.

Article  PubMed  PubMed Central  Google Scholar 

Hagenaars SP, Hill WD, Harris SE, Ritchie SJ, Davies G, Liewald DC, et al. Genetic prediction of male pattern baldness. PLoS Genet. 2017;13(2):e1006594.

Article  PubMed  PubMed Central  Google Scholar 

Ong J-S, Seviiri M, Dusingize JC, Wu Y, Han X, Shi J, et al. Uncovering the complex relationship between balding, testosterone and skin cancers in men. Nat Commun. 2023;14(1):5962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown CJ, Goss SJ, Lubahn DB, Joseph DR, Wilson EM, French FS, et al. Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. Am J Hum Genet. 1989;44(2):264–9.

CAS  PubMed  PubMed Central  Google Scholar 

Itami S, Sonoda T, Kurata S, Takayasu S. Mechanism of action of androgen in hair follicles. J Dermatol Sci. 1994;7:98–S103.

Article  Google Scholar 

Ceruti JM, Leirós GJ, Balañá ME. Androgens and androgen receptor action in skin and hair follicles. Mol Cell Endocrinol. 2018;465:122–33.

Article  CAS  PubMed  Google Scholar 

Gupta M, Mysore V. Classifications of patterned hair loss: a review. J Cutan Aesthet Surg. 2016;9(1):3–12.

Article  PubMed  PubMed Central  Google Scholar 

Hamilton JB. Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci. 1951;53(3):708–28.

Article  CAS  PubMed  Google Scholar 

Norwood OT. Male pattern baldness: classification and incidence. South Med J. 1975;68(11):1359–65.

Article  CAS  PubMed  Google Scholar 

Guarrera M, Cardo P, Arrigo P, Rebora A. Reliability of hamilton-norwood classification. Int J Trichology. 2009;1(2):120–2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Randall VA. Androgens and hair growth. Dermatol Ther. 2008;21(5):314–28.

Article  PubMed  Google Scholar 

Irwig MS, Kolukula S. Persistent sexual side effects of finasteride for male pattern hair loss. J Sex Med. 2011;8(6):1747–53.

Article  PubMed  Google Scholar 

Arif T, Dorjay K, Adil M, Sami M. Dutasteride in Androgenetic Alopecia: an update. Curr Clin Pharmacol. 2017;12(1):31–5.

Article  CAS  PubMed  Google Scholar 

Choi BY. Targeting Wnt/β-Catenin pathway for developing therapies for hair loss. Int J Mol Sci 2020, 21(14).

Kapoor M, Chao MJ, Johnson EC, Novikova G, Lai D, Meyers JL, Schulman J, Nurnberger JI, Porjesz B, Liu Y, et al. Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases. Nat Commun. 2021;12(1):5071.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song J, Kim D, Lee S, Jung J, Joo JWJ, Jang W. Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning. Commun Biology. 2022;5(1):615.

Article  CAS  Google Scholar 

Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease. Nat Neurosci. 2017;20(8):1052–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, Girdhar HTN. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nat Genet. 2019;51(4):659–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smemo S, Tena JJ, Kim K-H, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014;507(7492):371–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, et al. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019;51(4):592–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016;48(3):245–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thompson M, Gordon MG, Lu A, Tandon A, Halperin E, Gusev A, Ye CJ, Balliu B, Zaitlen N. Multi-context genetic modeling of transcriptional regulation resolves novel disease loci. Nat Commun. 2022;13(1):5704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finucane HK, Reshef YA, Anttila V, Slowikowski K, Gusev A, Byrnes A, Gazal S, Loh PR, Lareau C, Shoresh N, et al. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. Nat Genet. 2018;50(4):621–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Hysi P, Maj C, Heilmann-Heimbach S, Spector TD, Liu F, Kayser M. Genetic prediction of male pattern baldness based on large independent datasets. Eur J Hum Genet. 2023;31(3):321–8.

Article  CAS  PubMed  Google Scholar 

Giles GG, Severi G, Sinclair R, English DR, McCredie MRE, Johnson W, Boyle P, Hopper JL. Androgenetic Alopecia and prostate Cancer: findings from an Australian case-control Study1. Cancer Epidemiol Biomarkers Prev. 2002;11(6):549–53.

PubMed  Google Scholar 

Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348(6235):648–60.

Article  Google Scholar 

Fehrmann RS, Karjalainen JM, Krajewska M, Westra HJ, Maloney D, Simeonov A, Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, et al. Gene expression analysis identifies global gene dosage sensitivity in cancer. Nat Genet. 2015;47(2):115–25.

Article  CAS  PubMed  Google Scholar 

Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun. 2015;6:5890.

Article  CAS  PubMed  Google Scholar 

Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A, Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, et al. The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol. 2010;28(10):1045–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

The ENCODE. (ENCyclopedia of DNA elements) project. Science. 2004;306(5696):636–40.

Article  Google Scholar 

Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, Plagnol V. Bayesian test for colocalisation between Pairs of Genetic Association studies using Summary statistics. PLoS Genet. 2014;10(5):e1004383.

Article  PubMed  PubMed Central  Google Scholar 

Li YI, Wong G, Humphrey J, Raj T. Prioritizing Parkinson’s disease genes using population-scale transcriptomic data. Nat Commun. 2019;10(1):994.

Article  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences 2005, 102(43):15545–15550.

Bastarache L, Denny JC, Roden DM. Phenome-wide Association studies. JAMA. 2022;327(1):75–6.

Article  PubMed  PubMed Central  Google Scholar 

Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, et al. A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR. npj Genomic Med. 2019;4(1):3.

Article  CAS  Google Scholar 

Watanabe K, Stringer S, Frei O, Umićević Mirkov M, de Leeuw C, Polderman TJC, van der Sluis S, Andreassen OA, Neale BM, Posthuma D. A global overview of pleiotropy and genetic architecture in complex traits. Nat Genet. 2019;51(9):1339–48.

Article  CAS  PubMed  Google Scholar 

Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, et al. A Next Generation Connectivity Map: L1000 platform and the first 1,000,000 profiles. Cell. 2017;171(6):1437–1452e1417.

Article  CAS  PubMed  PubMed Central