Gross morphology of knee joint surfaces; femoral condyles (F) and tibial plateaus (T). Arrowheads indicate the MIA-induced degenerations in cartilage and subchondral bone tissues, whereas arrows point the improved tissue parts after UII or D treatments. S Sham, MIA Monosodium iodoacetate, V Vehicle, UII-2,4,8 Urotensin-II-2,4,8 µg, D Diclofenac