Peery AF, Sandler RS, Galanko JA, Bresalier RS, Figueiredo JC, Ahnen DJ, Barry EL, Baron JA. Risk factors for hemorrhoids on screening colonoscopy. PLoS ONE. 2015;10(9):e0139100.

Article  PubMed  PubMed Central  Google Scholar 

Halverson A. Hemorrhoids. Clin Colon Rectal Surg. 2007;20(02):077–85.

Article  Google Scholar 

Trompetto M, Clerico G, Cocorullo G, Giordano P, Marino F, Martellucci J, Milito G, Mistrangelo M, Ratto C. Evaluation and management of hemorrhoids: Italian society of colorectal surgery (SICCR) consensus statement. Tech Coloproctol. 2015;19(10):567–75.

Article  CAS  PubMed  Google Scholar 

Rubbini M, Ascanelli S. Classification and guidelines of hemorrhoidal disease: Present and future. World J Gastrointest Surg. 2019;11(3):117.

Article  PubMed  PubMed Central  Google Scholar 

Sun Z, Migaly J. Review of hemorrhoid disease: presentation and management. Clin Colon Rectal Surg. 2016;29(01):022–9.

Article  Google Scholar 

Yamana T. Japanese practice guidelines for anal disorders I. hemorrhoids. J anus Rectum colon. 2017;1(3):89–99.

Article  MathSciNet  PubMed  Google Scholar 

Ali SA, Shoeb MFR. Study of risk factors and clinical features of hemorrhoids. Int Surg J. 2017;4(6):1936–9.

Article  Google Scholar 

Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, Vavricka SR, Fiocchi C. Environmental triggers in IBD: a review of progress and evidence. Nat Reviews Gastroenterol Hepatol. 2018;15(1):39–49.

Article  Google Scholar 

Qin HY, Cheng CW, Tang XD, Bian ZX. Impact of psychological stress on irritable bowel syndrome. World J Gastroenterol. 2014;20(39):14126–31.

Article  PubMed  PubMed Central  Google Scholar 

Camilleri M, Di Lorenzo C. Brain-gut axis: from basic understanding to treatment of IBS and related disorders. J Pediatr Gastroenterol Nutr. 2012;54(4):446–53.

Article  PubMed  PubMed Central  Google Scholar 

Lee J-H, Kim H-E, Kang J-H, Shin J-Y, Song Y-M. Factors associated with hemorrhoids in Korean adults: Korean national health and nutrition examination survey. Korean J Family Med. 2014;35(5):227.

Article  Google Scholar 

Liu X, Zhang P, Guo C, Xu J, Hu M. Effect of rehabilitation therapy and nursing intervention on postoperative recovery of patients with hypertensive intracerebral hemorrhage. Experimental Therapeutic Med. 2019;17(6):4598–604.

Google Scholar 

Mehmet D, Kuvandik G, Özkan OV, Helvaci MR, Kaya H. A physiologic events’ Cascade, irritable bowel syndrome, is significantly Associated with Chronic Gastritis, Hemorrhoid, Urolithiasis, and Depression. Turkish J Emerg Med. 2007;7(3):115–20.

Google Scholar 

Davey Smith G, Ebrahim S. Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32(1):1–22.

Article  Google Scholar 

Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133–63.

Article  MathSciNet  PubMed  Google Scholar 

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508–18.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Mullins N, Forstner AJ, O’Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet. 2021;53(6):817–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okbay A, Baselmans BM, De Neve J-E, Turley P, Nivard MG, Fontana MA, Meddens SFW, Linnér RK, Rietveld CA, Derringer J. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016;48(6):624–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Consortium MDDWGPG. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry 2013, 18(4).

Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779.

Article  PubMed  PubMed Central  Google Scholar 

Dilling H. Internationale klassifikation psychischer störungen; 2015.

Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet. 2009;373(9659):234–9.

Article  CAS  PubMed  Google Scholar 

Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60(12):1187–92.

Article  PubMed  Google Scholar 

Zheng T, Ellinghaus D, Juzenas S, Cossais F, Burmeister G, Mayr G, Jørgensen IF, Teder-Laving M, Skogholt AH, Chen S. Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Gut. 2021;70(8):1538–49.

Article  CAS  PubMed  Google Scholar 

Tung JY, Do CB, Hinds DA, Kiefer AK, Macpherson JM, Chowdry AB, Francke U, Naughton BT, Mountain JL, Wojcicki A. Efficient replication of over 180 genetic associations with self-reported medical data. PLoS ONE. 2011;6(8):e23473.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, O’Connell J. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562(7726):203–9.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Leitsalu L, Haller T, Esko T, Tammesoo M-L, Alavere H, Snieder H, Perola M, Ng PC, Mägi R, Milani L. Cohort profile: Estonian biobank of the Estonian genome center, university of Tartu. Int J Epidemiol. 2015;44(4):1137–47.

Article  PubMed  Google Scholar 

Fritsche LG, Gruber SB, Wu Z, Schmidt EM, Zawistowski M, Moser SE, Blanc VM, Brummett CM, Kheterpal S, Abecasis GR. Association of polygenic risk scores for multiple cancers in a phenome-wide study: results from the Michigan Genomics Initiative. Am J Hum Genet. 2018;102(6):1048–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A. Genotyping informatics and quality control for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Genetics. 2015;200(4):1051–60.

Article  PubMed  PubMed Central  Google Scholar 

Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S, Danesh J, Butterworth AS, Staley JR. PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations. Bioinformatics. 2019;35(22):4851–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Marco S, Tiso D. Lifestyle and risk factors in Hemorrhoidal Disease. Front Surg 2021, 8.

Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two-sample mendelian randomization. Genet Epidemiol. 2016;40(7):597–608.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Del Greco MF, Minelli C, Zhao Q, Lawlor DA, Sheehan NA, Thompson J, Davey Smith G. Improving the accuracy of two-sample summary-data mendelian randomization: moving beyond the NOME assumption. Int J Epidemiol. 2019;48(3):728–42.

Article  PubMed  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.

Article  PubMed  PubMed Central  Google Scholar 

Kang H, Zhang A, Cai TT, Small DS. Instrumental variables estimation with some invalid instruments and its application to mendelian randomization. J Am Stat Assoc. 2016;111(513):132–44.

Article  MathSciNet  CAS  Google Scholar 

Hartwig F, Davey Smith G, Bowden J. summary data Mendelian randomisation via the zero modal pleiotropy assumption. International Journal of Epidemiology, 46 (6), 1985–1998.[dyx102]. https://doi.org/10.1093/ije/dyx102. International Journal of Epidemiology 2017, 1:14.

Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25.

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen C-Y, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemani G, Tilling K, Davey Smith G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017;13(11):e1007081.

Article  PubMed  PubMed Central  Google Scholar 

Elderon L, Whooley MA. Depression and cardiovascular disease. Prog Cardiovasc Dis. 2013;55(6):511–23.

Article