Metabolomic and genetic architecture of gestational diabetes subtypes

Gregory EC, Ely DM (2022) Trends and characteristics in gestational diabetes: United States, 2016–2020. Natl Vital Stat Rep 71:1–15

PubMed  Google Scholar 

Sweeting A, Wong J, Murphy HR, Ross GP (2022) A clinical update on gestational diabetes mellitus. Endocr Rev 43:763–793. https://doi.org/10.1210/endrev/bnac003

Article  PubMed  PubMed Central  Google Scholar 

Benhalima K, Van Crombrugge P, Moyson C et al (2019) Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance. Diabetologia 62:2118–2128. https://doi.org/10.1007/s00125-019-4961-7

Article  CAS  PubMed  Google Scholar 

Madsen LR, Gibbons KS, Ma RCW et al (2021) Do variations in insulin sensitivity and insulin secretion in pregnancy predict differences in obstetric and neonatal outcomes? Diabetologia 64:304–312. https://doi.org/10.1007/s00125-020-05323-0

Article  CAS  PubMed  Google Scholar 

Powe CE, Allard C, Battista MC et al (2016) Heterogeneous contribution of insulin sensitivity and secretion defects to gestational diabetes mellitus. Diabetes Care 39:1052–1055. https://doi.org/10.2337/dc15-2672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang N, Song L, Sun B et al (2021) Contribution of gestational diabetes mellitus heterogeneity and prepregnancy body mass index to large-for-gestational-age infants – a retrospective case–control study. J Diabetes 13:307–317. https://doi.org/10.1111/1753-0407.13113

Article  CAS  PubMed  Google Scholar 

Immanuel J, Simmons D, Harreiter J et al (2021) Metabolic phenotypes of early gestational diabetes mellitus and their association with adverse pregnancy outcomes. Diabet Med 38:e14413. https://doi.org/10.1111/dme.14413

Article  CAS  PubMed  Google Scholar 

Selen DJ, Edelson PK, James K et al (2022) Physiological subtypes of gestational glucose intolerance and risk of adverse pregnancy outcomes. Am J Obstet Gynecol 226:241.e1-241.e14. https://doi.org/10.1016/j.ajog.2021.08.016

Article  CAS  PubMed  Google Scholar 

Powe CE, Hivert MF, Udler MS (2020) Defining heterogeneity among women with gestational diabetes mellitus. Diabetes 69:2064–2074. https://doi.org/10.2337/dbi20-0004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Kuang A, Bain JR et al (2021) Maternal metabolites associated with gestational diabetes mellitus and a postpartum disorder of glucose metabolism. J Clin Endocrinol Metab 106:3283–3294. https://doi.org/10.1210/clinem/dgab513

Article  PubMed  PubMed Central  Google Scholar 

Pervjakova N, Moen GH, Borges MC et al (2022) Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Hum Mol Genet 31:3377–3391. https://doi.org/10.1093/hmg/ddac050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Powe CE, Kwak SH (2020) Genetic studies of gestational diabetes and glucose metabolism in pregnancy. Curr Diab Rep 20:69. https://doi.org/10.1007/s11892-020-01355-3

Article  PubMed  PubMed Central  Google Scholar 

Metzger BE, Lowe LP, Dyer AR et al (2008) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358:1991–2002. https://doi.org/10.1056/NEJMoa0707943

Article  PubMed  Google Scholar 

International Association of Diabetes and Pregnancy Groups (2010) International Association of Diabetes and Pregnancy Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 33:676–682. https://doi.org/10.2337/dc09-1848

Article  CAS  Google Scholar 

Radaelli T, Farrell KA, Huston-Presley L et al (2010) Estimates of insulin sensitivity using glucose and C-peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test. Diabetes Care 33:490–494. https://doi.org/10.2337/dc09-1463

Article  CAS  PubMed  Google Scholar 

Stumvoll M, Mitrakou A, Pimenta W et al (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23:295–301. https://doi.org/10.2337/diacare.23.3.295

Article  CAS  PubMed  Google Scholar 

Stumvoll M, Van Haeften T, Fritsche A, Gerich J (2001) Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. Diabetes Care 24:796–797. https://doi.org/10.2337/diacare.24.4.796

Article  CAS  PubMed  Google Scholar 

Scholtens DM, Bain JR, Reisetter AC et al (2016) Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth. Diabetes 65:2039–2050. https://doi.org/10.2337/db15-1748

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Zhernakova DV, Kurilshikov A et al (2022) Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome. Nat Med 28:2333–2343. https://doi.org/10.1038/s41591-022-02014-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Yekutieli D (2001) The control of false discovery rate in multiple testing under dependency. Ann Stat 29:1165–1188. https://doi.org/10.1214/aos/1013699998

Article  MathSciNet  Google Scholar 

Friedman J, Hastie T, Tibshirani R (2008) Sparse inverse covariance estimation with the graphical lasso. Biostatistics 9:432–441. https://doi.org/10.1093/biostatistics/kxm045

Article  PubMed  Google Scholar 

Zhao T, Liu H, Roeder K, Lafferty J, Wasserman L (2012) The huge package for high-dimensional undirected graph estimation in R. J Mach Learn Res 13:1059–1062

MathSciNet  PubMed  PubMed Central  Google Scholar 

Csardi G, Nepusz T (2006) The igraph software package for complex network research. Interjournal Complex Systems 1695, https://igraph.org

Kuang A, Hayes MG, Hivert MF, Balasubramanian R, Lowe WL Jr, Scholtens DM (2022) Network approaches to integrate analyses of genetics and metabolomics data with applications to fetal programming studies. Metabolites 12(6):512. https://doi.org/10.3390/metabo12060512

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayes MG, Urbanek M, Hivert MF et al (2013) Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes 62(9):3282–3291. https://doi.org/10.2337/db12-1692

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laurie CC, Doheny KF, Mirel DB et al (2010) Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol 34:591–602. https://doi.org/10.1002/gepi.20516

Article  PubMed  PubMed Central  Google Scholar 

Zheng X, Levine D, Shen J, Gogarten SM, Laurie C, Weir BS (2012) A high-performance computing toolset for relatedness and principal component analysis of SNP data. Bioinformatics 28:3326–3328. https://doi.org/10.1093/bioinformatics/bts606

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das S, Forer L, Schonherr S et al (2016) Next-generation genotype imputation service and methods. Nat Genet 48:1284–1287. https://doi.org/10.1038/ng.3656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taliun D, Harris DN, Kessler MD et al (2021) Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature 590:290–299. https://doi.org/10.1038/s41586-021-03205-y

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Wang QY, You LH, Xiang LL, Zhu YT, Zeng Y (2021) Current progress in metabolomics of gestational diabetes mellitus. World J Diabetes 12:1164–1186. https://doi.org/10.4239/wjd.v12.i8.1164

Article  PubMed  PubMed Central  Google Scholar 

Sikorski C, Azab S, de Souza RJ et al (2022) Serum metabolomic signatures of gestational diabetes in South Asian and white European women. BMJ Open Diabetes Res Care 10:e002733

Article  PubMed  PubMed Central  Google Scholar 

Karamitri A, Jockers R (2019) Melatonin in type 2 diabetes mellitus and obesity. Nat Rev Endocrinol 15:105–125. https://doi.org/10.1038/s41574-018-0130-1

Article  CAS  PubMed  Google Scholar 

Kivela A (1991) Serum melatonin during human pregnancy. Acta Endocrinol (Copenh) 124:233–237

CAS  PubMed  Google Scholar 

Ejaz H, Figaro JK, Woolner AMF, Thottakam BMV, Galley HF (2020) Maternal serum melatonin increases during pregnancy and falls immediately after delivery implicating the placenta as a major source of melatonin. Front Endocrinol (Lausanne) 11:623038. https://doi.org/10.3389/fendo.2020.623038

Article  PubMed  Google Scholar 

Lyssenko V, Nagorny CL, Erdos MR et al (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41:82–88. https://doi.org/10.1038/ng.288

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