WHO. Epilepsy [Internet]. 2023 Feb 9 [cited 2023 Aug 11]. Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy.

•• Johnson EL, Kaplan PW. Caring for transgender patients with epilepsy. Epilepsia. 2017;58(10):1667–72. An important review highlighting epilepsy care in transgender people with epilepsy and common comorbidities.

Waldman G, Benson R. Epilepsy care in transgender patients. Curr Neurol Neurosci Rep. 2022;22(8):451–8.

Article  PubMed  Google Scholar 

•• Coleman E, Radix AE, Bouman WP, Brown GR, de Vries ALC, Deutsch MB, et al. Standards of care for the health of transgender and gender diverse people, version 8. Int J Transgender Health. 2022;23(Suppl 1):S1–259. An important standard of care guideline reference for gender-affirming hormonal treatment.

Zhang Q, Goodman M, Adams N, Corneil T, Hashemi L, Kreukels B, et al. Epidemiological considerations in transgender health: a systematic review with focus on higher quality data. Int J Transgender Health. 2020;21(2):125–37.

Article  Google Scholar 

• Rosendale N, Wong JO, Flatt JD, Whitaker E. Sexual and gender minority health in neurology: a scoping review. JAMA Neurol. 2021;78(6):747–54. A literature review of neurological disease and care in sexual and gender minority individual highlighting the need for research in this field.

Sequeira GM, Kidd K, Coulter RWS, Miller E, Garofalo R, Ray KN. Affirming transgender youths’ names and pronouns in the electronic medical record. JAMA Pediatr. 2020;174(5):501–3.

Article  PubMed  PubMed Central  Google Scholar 

Bindman J, Ngo A, Zamudio-Haas S, Sevelius J. Health care experiences of patients with nonbinary gender identities. Transgender Health. 2022;7(5):423–9.

Article  PubMed  Google Scholar 

Reisner SL, Poteat T, Keatley J, Cabral M, Mothopeng T, Dunham E, et al. Global health burden and needs of transgender populations: a review. Lancet Lond Engl. 2016;388(10042):412–36.

Article  Google Scholar 

Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2017;102(11):3869–903.

Article  PubMed  Google Scholar 

Radix A. Hormone therapy for transgender adults. Urol Clin North Am. 2019;46(4):467–73.

Article  PubMed  Google Scholar 

Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342(5):314–9.

Article  PubMed  CAS  Google Scholar 

Abou-Khalil BW. Update on antiseizure medications 2022. Contin Minneap Minn. 2022;28(2):500–35.

Google Scholar 

Munger Clary H, Josephson SA, Franklin G, Herman ST, Hopp JL, Hughes I, et al. Seizure frequency process and outcome quality measures: quality improvement in neurology. Neurology. 2022;98(14):583–90.

Article  PubMed  Google Scholar 

Velíšková J, DeSantis KA. Sex and hormonal influences on seizures and epilepsy. Horm Behav. 2013;63(2):267–77.

Article  PubMed  Google Scholar 

Taubøll E, Sveberg L, Svalheim S. Interactions between hormones and epilepsy. Seizure. 2015;28:3–11.

Article  PubMed  Google Scholar 

• Taubøll E, Isojärvi JIT, Herzog AG. The interactions between reproductive hormones and epilepsy. Handb Clin Neurol. 2021;182:155–74. A chapter from the Handbook of Clinical Neurology focusing on the detailed and complex interactions of reproductive hormones and epilepsy.

Carvalho V, Colonna I, Curia G, Ferretti MT, Arabia G, Molnar MJ, et al. Sex steroid hormones and epilepsy: effects of hormonal replacement therapy on seizure frequency of postmenopausal women with epilepsy-a systematic review. Eur J Neurol. 2023;30(9):2884–98.

Article  PubMed  Google Scholar 

Nucera B, Rinaldi F, Dono F, Lanzone J, Evangelista G, Consoli S, et al. Progesterone and its derivatives for the treatment of catamenial epilepsy: a systematic review. Seizure. 2023;109:52–9.

Article  PubMed  CAS  Google Scholar 

Heiry M, Afra P, Matsuo F, Greenlee JE, Clardy SL. Improvement of GAD65-associated autoimmune epilepsy with testosterone replacement therapy. Neurol Neuroimmunol Neuroinflammation. 2015;2(5): e142.

Article  Google Scholar 

Reimers A. Hormone replacement therapy with estrogens may reduce lamotrigine serum concentrations: a matched case-control study. Epilepsia. 2017;58(1):e6–9.

Sabers A, Buchholt JM, Uldall P, Hansen EL. Lamotrigine plasma levels reduced by oral contraceptives. Epilepsy Res. 2001;47(1–2):151–4.

Article  PubMed  CAS  Google Scholar 

Herzog AG, Blum AS, Farina EL, Maestri XE, Newman J, Garcia E, et al. Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use. Neurology. 2009;72(10):911–4.

Article  PubMed  CAS  Google Scholar 

Dutton C, Foldvary-Schaefer N. Contraception in women with epilepsy: pharmacokinetic interactions, contraceptive options, and management. Int Rev Neurobiol. 2008;83:113–34.

Article  PubMed  Google Scholar 

Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia. 2007;48(7):1223–44.

Article  PubMed  CAS  Google Scholar 

de Leon J. The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part I: a summary of the current state for clinicians. Rev Psiquiatr Salud Ment. 2015;8(2):97–115.

Greene SA, Kwak C, Kamin M, Vernillet L, Glenn KJ, Gabriel L, et al. Effect of cenobamate on the single-dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects. Clin Transl Sci. 2022;15(4):899–911.

Article  PubMed  CAS  Google Scholar 

Schoretsanitis G, Deligiannidis KM, Paulzen M, Spina E, de Leon J. Drug-drug interactions between psychotropic medications and oral contraceptives. Expert Opin Drug Metab Toxicol. 2022;18(6):395–411.

Article  PubMed  CAS  Google Scholar 

Rauchenzauner M, Deichmann S, Pittschieler S, Bergmann M, Prieschl M, Unterberger I, et al. Bidirectional interaction between oral contraception and lamotrigine in women with epilepsy - role of progestins. Seizure. 2020;74:89–92.

Article  PubMed  Google Scholar 

Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol. 2006;61(2):191–9.

Article  PubMed  CAS  Google Scholar 

CDC contraceptive guidance [Internet]. 2023 [cited 2023 Aug 11]. Available from: https://www.cdc.gov/reproductivehealth/contraception/contraception_guidance.htm.

Stefanidou M, Montouris G. Reproductive and sexual health concerns in transition-age adolescents and young adults with epilepsy. Semin Pediatr Neurol. 2020;36: 100855.

Article  PubMed  Google Scholar 

Isojärvi JI, Laatikainen TJ, Pakarinen AJ, Juntunen KT, Myllylä VV. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med. 1993;329(19):1383–8.

Article  PubMed  Google Scholar 

Isojärvi JIT, Löfgren E, Juntunen KST, Pakarinen AJ, Päivänsalo M, Rautakorpi I, et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology. 2004;62(2):247–53.

Article  PubMed  Google Scholar 

Harden CL, Nikolov BG, Kandula P, Labar DR, Pannullo S. Effect of levetiracetam on testosterone levels in male patients. Epilepsia. 2010;51(11):2348–51.

Article  PubMed  CAS  Google Scholar 

Wu D, Chen L, Ji F, Si Y, Sun H. The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy. Epilepsia. 2018;59(7):1344–50.

Article  PubMed  CAS  Google Scholar