Arif H, Buchsbaum R, Weintraub D, Koyfman S, Salas-Humara C, Bazil CW, et al. Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology. 2007;68(20):1701–9.

Article  CAS  PubMed  Google Scholar 

Klassen BD, Sadler RM. Induction of hypersensitivity to a previously tolerated antiepileptic drug by a second antiepileptic drug. Epilepsia. 2001;42(3):433–5.

Article  CAS  PubMed  Google Scholar 

•• Wilkerson RG. Drug Hypersensitivity Reactions. Immunol Allergy Clin North Am. 2023;43(3):473–89. Excellent review of the early identification and management of drug hypersensitivity reactions.

Article  PubMed  Google Scholar 

Bolognia J, Schaffer JV, Cerroni L. Dermatology. Netherlands: Elsevier; 2018. p. 2880.

Google Scholar 

Frey N, Bodmer M, Bircher A, Ruegg S, Jick SS, Meier CR, et al. The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs. Epilepsia. 2017;58(12):2178–85.

Article  CAS  PubMed  Google Scholar 

•• Mani R, Monteleone C, Schalock PC, Truong T, Zhang XB, Wagner ML. Rashes and other hypersensitivity reactions associated with antiepileptic drugs: a review of current literature. Seizure. 2019;71:270–8. Excellent recent clinical review that is very well-referenced.

Article  PubMed  Google Scholar 

Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR Jr, Bazil CW. Cross-sensitivity of skin rashes with antiepileptic drug use. Neurology. 2008;71(19):1527–34.

Article  CAS  PubMed  Google Scholar 

Bloch KM, Sills GJ, Pirmohamed M, Alfirevic A. Pharmacogenetics of antiepileptic drug-induced hypersensitivity. Pharmacogenomics. 2014;15(6):857–68.

Article  CAS  PubMed  Google Scholar 

Guvenir H, Dibek Misirlioglu E, Civelek E, Toyran M, Buyuktiryaki B, Ginis T, et al. The frequency and clinical features of hypersensitivity reactions to antiepileptic drugs in children: a prospective study. J Allergy Clin Immunol Pract. 2018;6:2043–50.

Article  PubMed  Google Scholar 

Ziemer M, Kardaun SH, Liss Y, Mockenhaupt M. Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with lupus erythematosus: a descriptive study of 17 cases from a national registry and review of the literature. Br J Dermatol. 2012;166(3):575–600.

Article  CAS  PubMed  Google Scholar 

Borrelli EP, Lee EY, Descoteaux AM, Kogut SJ, Caffrey AR. Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System. Epilepsia. 2018;59(12):2318–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Zhu J, Chen G, He Z, Zheng Y, Gao S, Li J, et al. Stevens-Johnson syndrome/toxic epidermal necrolysis in patients treated with immune checkpoint inhibitors: a safety analysis of clinical trials and FDA pharmacovigilance database. EClinicalMedicine. 2021;37:100951. Review of reports of the SCARs with immune checkpoint inhibitors, which are being increasingly used for specific cancers.

Article  PubMed  PubMed Central  Google Scholar 

•• Saito Y, Abe R. New insights into the diagnosis and management of Stevens-Johnson syndrome and toxic epidermal necrolysis. Curr Opin Allergy Clin Immunol. 2023;23(4):271–8. Excellent review that cites the quality of evidence.

Article  PubMed  Google Scholar 

• Biswas M, Ershadian M, Shobana J, Nguyen AH, Sukasem C. Associations of HLA genetic variants with carbamazepine-induced cutaneous adverse drug reactions: an updated meta-analysis. Clin Transl Sci. 2022;15(8):1887–905. Meta-analysis of HLA variants associated with carbamazepine SCARs.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Guin D, Hasija Y, Kukreti R. Assessment of clinically actionable pharmacogenetic markers to stratify anti-seizure medications. Pharmacogenomics J. 2023;23(6):149–60. Review provides a list of tests to implement to better predict SCARs.

Article  CAS  PubMed  Google Scholar 

Blaszczyk B, Szpringer M, Czuczwar SJ, Lason W. Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions. Pharmacol Rep. 2013;65(2):399–409.

Article  PubMed  Google Scholar 

Blaszczyk B, Lason W, Czuczwar SJ. Antiepileptic drugs and adverse skin reactions: an update. Pharmacol Rep. 2015;67(3):426–34.

Article  CAS  PubMed  Google Scholar 

Loscalzo J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison’s principles of internal medicine. New York: McGraw Hill; 2022.

Google Scholar 

Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993;129(1):92–6.

Article  CAS  PubMed  Google Scholar 

DE Akpinar F. Drug eruptions: an 8-year study including 106 inpatients at a dermatology clinic in Turkey. Indian J Dermatol. 2012;57(3):194–8.

Article  PubMed  PubMed Central  Google Scholar 

Heelan K, et al. Cutaneous reactions to drugs. In: Kang S, et al., editors. Fitzpatrick’s dermatology. New York: McGraw-Hill Education; 2019.

Google Scholar 

Soutor C, Hordinsky MK. Clinical dermatology: diagnosis and management of common disorders. 2nd ed. New York: McGraw Hill; 2022. xiii, p. 591.

Google Scholar 

Feldmeyer L, Heidemeyer K, Yawalkar N. Acute generalized exanthematous pustulosis: pathogenesis, genetic background, clinical variants and therapy. Int J Mol Sci. 2016;17(8):1214.

Article  PubMed  PubMed Central  Google Scholar 

Creswell C. Urticaria and drug rashes. In: Soutor C, Hordinsky MK, editors. Clinical dermatology. New York, NY: McGraw-Hill Education; 2017.

Google Scholar 

Pereira de Silva N, Piquioni P, Kochen S, Saidon P. Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. Eur J Clin Pharmacol. 2011;67(5):463–70.

Article  CAS  PubMed  Google Scholar 

• Bedouelle E, Ben Said B, Tetart F, Milpied B, Welfringer-Morin A, Maruani A, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): Series of 49 French pediatric cases. J Allergy Clin Immunol Pract. 2022;10(1):267–74 e5. Excellent and detailed multi-center cohort of RegiSCAR assessed children experiencing DRESS.

Article  CAS  PubMed  Google Scholar 

Artukovic M, Kustelega J, Lugovic-Mihic L. DRESS syndrome with mild manifestations as a diagnostic and therapeutic problem: case report. Acta Clin Croat. 2010;49(4):479–84.

PubMed  Google Scholar 

Sharma A, Kumar A. Identification of novel signal of clobazam-associated drug reaction with eosinophilia and systemic symptoms syndrome: a disproportionality analysis. Acta Neurol Scand. 2022;146(5):623–7.

Article  CAS  PubMed  Google Scholar 

Thoms A, Muller P, Schaufelberger B, De La Torre E, Smugar SS. A comprehensive analysis of topiramate and drug reaction with eosinophilia and systemic symptoms. Cureus. 2023;15(1): e33713.

PubMed  PubMed Central  Google Scholar 

Micheletti R, Rosenbach M, Wintroub BU, Shinkai K. Cutaneous drug reactions. In: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, editors. Harrison’s principles of internal medicine, 20e. New York, NY: McGraw-Hill Education; 2018.

Google Scholar 

Choudhary S, McLeod M, Torchia D, Romanelli P. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthet Dermatol. 2013;6(6):31–7.

PubMed  PubMed Central  Google Scholar 

Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y, Chu CY, Creamer D, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013;169(5):1071–80.

Article  CAS  PubMed  Google Scholar 

Sethuraman G, Sharma VK, Pahwa P, Khetan P. Causative drugs and clinical outcome in Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children. Indian J Dermatol. 2012;57(3):199–200.

Article  PubMed  PubMed Central  Google Scholar 

Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau JC, Revuz J, Wolkenstein P. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 2000;115(2):149–53.

Article  CAS  PubMed  Google Scholar 

• Liew YCC, Choo KJL, Oh CC, Pang SM, Yeo YW, Lee HY. Mycoplasma-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: case-control analysis of a cohort managed in a specialized center. J Am Acad Dermatol. 2022;86(4):811–7. Review of 6 patients with Mycoplasma-linked SJS/TEN and comparing their features to a drug-induced control SJS/TEN group.

Article  PubMed  Google Scholar 

•• McKinley BJ, Allen ME, Michels N. Photodistributed Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and proposal for a new diagnostic classification. Eur J Med Res. 2023;28(1):188. Interesting literature review of 12 cases with UV-light associated SJS/TEN.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Godhwani N, Bahna SL. Antiepilepsy drugs and the immune system. Ann Allergy Asthma Immunol. 2016;117(6):634–40.

Article  CAS  PubMed  Google Scholar 

Sperling MR, Klein P, Aboumatar S, Gelfand M, Halford JJ, Krauss GL, et al. Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study. Epilepsia. 2020;61(6):1099–108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar S, Ramanujam B, Chandra PS, Dash D, Mehta S, Anubha S, et al. Randomized controlled study comparing the efficacy of rapid and slow withdrawal of antiepileptic drugs during long-term video-EEG monitoring. Epilepsia. 2018;59(2):460–7.

Article  CAS  PubMed  Google Scholar