Impact of thyroid hormone treatment on maternal pregnancy outcomes in women with subclinical hypothyroidism without TPOAb: a retrospective cross-sectional study

Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27(3):315–89.

Article  PubMed  Google Scholar 

Taylor PN, Muller I, Nana M, Velasco I, Lazarus JH. Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy. Best Pract Res Clin Endocrinol Metab. 2020;34(4): 101436.

Article  CAS  PubMed  Google Scholar 

Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S, et al. Levothyroxine in women with thyroid peroxidase antibodies before conception. N Engl J Med. 2019;380(14):1316–25.

Article  CAS  PubMed  Google Scholar 

van Dijk MM, Vissenberg R, Fliers E, van der Post JAM, van der Hoorn MP, de Weerd S, et al. Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol. 2022;10(5):322–9.

Article  PubMed  Google Scholar 

Nazarpour S, Ramezani Tehrani F, Simbar M, Tohidi M, Minooee S, Rahmati M, et al. Effects of levothyroxine on pregnant women with subclinical hypothyroidism, negative for thyroid peroxidase antibodies. J Clin Endocrinol Metab. 2018;103(3):926–35.

Article  PubMed  Google Scholar 

Thyroid Disease in Pregnancy. ACOG practice bulletin, number 223. Obstet Gynecol. 2020;135(6):e261–74.

Article  Google Scholar 

Liu H, Shan Z, Li C, Mao J, Xie X, Wang W, et al. Maternal subclinical hypothyroidism, thyroid autoimmunity, and the risk of miscarriage: a prospective cohort study. Thyroid. 2014;24(11):1642–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth; Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, et al. Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis. JAMA. 2019;322(7):632–41.

Zhu P, Chu R, Pan S, Lai X, Ran J, Li X. Impact of TPOAb-negative maternal subclinical hypothyroidism in early pregnancy on adverse pregnancy outcomes. Ther Adv Endocrinol Metab. 2021;12:20420188211054690.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magri F, Bellingeri C, De Maggio I, Croce L, Coperchini F, Rotondi M, et al. first-trimester serum TSH in the 4–10 mIU/L range is associated with obstetric complications in thyroid peroxidase antibody-negative women. J Endocrinol Invest. 2022.

Veltri F, Belhomme J, Kleynen P, Grabczan L, Rozenberg S, Pepersack T, et al. Maternal thyroid parameters in pregnant women with different ethnic backgrounds: do ethnicity-specific reference ranges improve the diagnosis of subclinical hypothyroidism? Clin Endocrinol (Oxf). 2017;86(6):830–6.

Article  CAS  PubMed  Google Scholar 

Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081–125.

Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization guideline. Diabetes Res Clin Pract. 2014;103(3):341–63.

Lee SY, Cabral HJ, Aschengrau A, Pearce EN. Associations between maternal thyroid function in pregnancy and obstetric and perinatal outcomes. J Clin Endocrinol Metab. 2020;105(5):e2015–23.

Article  PubMed  Google Scholar 

Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, et al. Subclinical hypothyroidism in pregnancy: a systematic review and meta-analysis. Thyroid. 2016;26(4):580–90.

Kyrilli A, Unuane D, Poppe KG. Thyroid autoimmunity and pregnancy in euthyroid women. Best Pract Res Clin Endocrinol Metab. 2023;37(2): 101632.

Article  PubMed  Google Scholar 

Li MF, Ma L, Feng QM, Zhu Y, Yu TP, Ke JF, et al. Effects of maternal subclinical hypothyroidism in early pregnancy diagnosed by different criteria on adverse perinatal outcomes in Chinese women with negative TPOAb. Front Endocrinol (Lausanne). 2020;11: 580380.

Article  PubMed  Google Scholar 

Kent NL, Young SL, Akison LK, Cuffe JSM. Is the link between elevated TSH and gestational diabetes mellitus dependant on diagnostic criteria and thyroid antibody status: a systematic review and meta-analysis. Endocrine. 2021;74(1):38–49.

Article  CAS  PubMed  Google Scholar 

Biondi B, Kahaly GJ, Robertson RP. Thyroid dysfunction and diabetes mellitus: two closely associated disorders. Endocr Rev. 2019;40(3):789–824.

Article  PubMed  PubMed Central  Google Scholar 

Luo J, Wang X, Yuan L, Guo L. Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis. Endocrine. 2021;73(3):550–60.

Article  CAS  PubMed  Google Scholar 

Liu Y, Guo F, Maraka S, Zhang Y, Zhang C, Korevaar TIM, et al. Associations between human chorionic gonadotropin, maternal free thyroxine, and gestational diabetes mellitus. Thyroid. 2021;31(8):1282–8.

Article  CAS  PubMed  Google Scholar 

Sitoris G, Veltri F, Ichiche M, Kleynen P, Praet JP, Rozenberg S, et al. Association between thyroid autoimmunity and gestational diabetes mellitus in euthyroid women. Eur Thyroid J. 2022;11(2): e210142.

Article  PubMed  PubMed Central  Google Scholar 

Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, et al. Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2022;10(4):243–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casey BM, Dashe JS, Wells CE, McIntire DD, Byrd W, Leveno KJ, et al. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol. 2005;105(2):239–45.

Article  PubMed  Google Scholar 

Sitoris G, Veltri F, Kleynen P, Cogan A, Belhomme J, Rozenberg S, et al. The impact of thyroid disorders on clinical pregnancy outcomes in a real-world study setting. Thyroid. 2020;30(1):106–15.

Article  CAS  PubMed  Google Scholar 

Wilson KL, Casey BM, McIntire DD, Halvorson LM, Cunningham FG. Subclinical thyroid disease and the incidence of hypertension in pregnancy. Obstet Gynecol. 2012;119(2 Pt 1):315–20.

Article  PubMed  Google Scholar 

Korevaar TI, Steegers EA, Chaker L, Medici M, Jaddoe VW, Visser TJ, et al. The risk of preeclampsia according to high thyroid function in pregnancy differs by hCG concentration. J Clin Endocrinol Metab. 2016;101(12):5037–43.

Article  CAS  PubMed  Google Scholar 

Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016;388(10063):3027–35.

Article  PubMed  PubMed Central  Google Scholar 

Ramadurai SM, Nielsen HC, Chen Y, Hatzis D, Sosenko IR. Differential effects in vivo of thyroid hormone on the expression of surfactant phospholipid, surfactant protein mRNA and antioxidant enzyme mRNA in fetal rat lung. Exp Lung Res. 1998;24(5):641–57.

Article  CAS  PubMed  Google Scholar 

De Vito P, Incerpi S, Pedersen JZ, Luly P, Davis FB, Davis PJ. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid. 2011;21(8):879–90.

Article  PubMed  Google Scholar 

Barjaktarovic M, Korevaar TI, Chaker L, Jaddoe VW, de Rijke YB, Visser TJ, et al. The association of maternal thyroid function with placental hemodynamics. Hum Reprod. 2017;32(3):653–61.

CAS  PubMed  Google Scholar 

Yang Y, Hou Y, Wang H, Gao X, Wang X, Li J, et al. Maternal thyroid dysfunction and gestational anemia risk: meta-analysis and new data. Front Endocrinol (Lausanne). 2020;11:201.

Article  PubMed  Google Scholar 

Hess SY, Zimmermann MB, Arnold M, Langhans W, Hurrell RF. Iron deficiency anemia reduces thyroid peroxidase activity in rats. J Nutr. 2002;132(7):1951–5.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, et al. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 2017;130(20):2161–70.

Article  CAS  PubMed  Google Scholar 

Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 2000;71(5 Suppl):1280S-S1284.

Article  CAS  PubMed  Google Scholar 

Zhang Q, Lu XM, Zhang M, Yang CY, Lv SY, Li SF, et al. Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements. Sci Rep. 2021;11(1):1347.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernik A, Szczepanek-Parulska E, Filipowicz D, Abdolall A, Borowczyk M, Wrotkowska E, et al. The hepcidin concentration decreases in hypothyroid patients with Hashimoto’s thyroiditis following restoration of euthyroidism. Sci Rep. 2019;9(1):16222.

Article  PubMed  PubMed Central  Google Scholar 

Fandrey J, Pagel H, Frede S, Wolff M, Jelkmann W. Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro. Exp Hematol. 1994;22(3):272–7.

CAS  PubMed  Google Scholar 

Stagnaro-Green A. Thyroid disease in pregnancy: a touch of clarity. Thyroid. 2022;32(4):347–8.

Article  CAS  PubMed  Google Scholar 

Chen J, Zhu J, Huang X, Zhao S, Xiang H, Zhou P, et al. Subclinical hypothyroidism with negative for thyroid peroxidase antibodies in pregnancy: intellectual development of offspring. Thyroid. 2022;32(4):449–58.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif