Oriowo MA, Oommen E, Khan I. Hyperthyroidism enhances 5-HT-induced contraction of the rat pulmonary artery: role of calcium-activated chloride channel activation. Eur J Pharmacol. 2011;669(1–3):108–14.

Article  CAS  PubMed  Google Scholar 

Hassanpour H, Afzali A, Fatemi Tabatabaie R, Torabi M, Alavi Y. Cardiac renin-angiotensin system (gene expression) and plasma Ang II in chickens with T3-induced pulmonary hypertension. Br Poult Sci. 2016;57(4):444–50.

Article  CAS  PubMed  Google Scholar 

Basset A, Blanc J, Messas E, Hagège A, Elghozi JL. Renin-angiotensin system contribution to cardiac hypertrophy in experimental hyperthyroidism: an echocardiographic study. J Cardiovasc Pharmacol. 2001;37(2):163–72.

Article  CAS  PubMed  Google Scholar 

Asahi T, Shimabukuro M, Oshiro Y, Yoshida H, Takasu N. Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats. Thyroid. 2001;11(11):1009–15.

Article  CAS  PubMed  Google Scholar 

Kobori H, Ichihara A, Miyashita Y, Hayashi M, Saruta T. Mechanism of hyperthyroidism-induced renal hypertrophy in rats. J Endocrinol. 1998;159(1):9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carneiro-Ramos MS, Silva VB, Santos RA, Barreto-Chaves ML. Tissue-specific modulation of angiotensin-converting enzyme (ACE) in hyperthyroidism. Peptides. 2006;27(11):2942–9.

Article  CAS  PubMed  Google Scholar 

Rodríguez-Gómez I, Manuel Moreno J, Jimenez R, Quesada A, Montoro-Molina S, Vargas-Tendero P, Wangensteen R, Vargas F. Effects of arginase inhibition in hypertensive hyperthyroid rats. Am J Hypertens. 2015;28(12):1464–72.

Article  PubMed  Google Scholar 

Rodriguez-Gomez I, Banegas I, Wangensteen R, Quesada A, Jiménez R, Gómez-Morales M, O’Valle F, Duarte J, Vargas F. Influence of thyroid state on cardiac and renal capillary density and glomerular morphology in rats. J Endocrinol. 2013;216(1):43–51.

Article  CAS  PubMed  Google Scholar 

Kobori H, Ichihara A, Miyashita Y, Hayashi M, Saruta T. Local renin–angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy. J Endocrinol. 1999;160(1):43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007;59(3):251–87.

Article  CAS  PubMed  Google Scholar 

Kaltenecker CC, Domenig O, Kopecky C, Antlanger M, Poglitsch M, Berlakovich G, Kain R, Stegbauer J, Rahman M, Hellinger R, Gruber C. Critical role of neprilysin in kidney angiotensin metabolism. Circul Res. 2020;127(5):593–606.

Article  CAS  Google Scholar 

Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme: cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275(43):33238–43.

Article  CAS  PubMed  Google Scholar 

Santos RA, e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP. Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas. Proceedings of the National Academy of Sciences. 2003; 100(14):8258-63.

Chappell MC, Modrall JG, Diz DI, Ferrario CM. Novel aspects of the renal renin-angiotensin system: angiotensin-(1–7), ACE2 and blood pressure regulation. Kidney Blood Press Regul. 2004;143:77–89.

Article  Google Scholar 

da Silveira KD, Pompermayer Bosco KS, Diniz LR, Carmona AK, Cassali GD, Bruna-Romero O, de Sousa LP, Teixeira MM, Santos RA. Simões E Silva AC, Ribeiro Vieira MA. ACE2–angiotensin-(1–7)-Mas axis in renal ischaemia/reperfusion injury in rats. Clin Sci. 2010;119(9):385–94.

Article  Google Scholar 

Simões e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1‐7) and M as receptor axis in inflammation and fibrosis. Br J Pharmacol. 2013;169(3):477–92.

Article  PubMed  PubMed Central  Google Scholar 

Diniz GP, Senger N, Carneiro-Ramos MS, Santos RA, Barreto-Chaves ML. Cardiac ACE2/angiotensin 1–7/Mas receptor axis is activated in thyroid hormone-induced cardiac hypertrophy. Ther Adv Cardiovasc Dis. 2016;10(4):192–202.

Article  CAS  PubMed  Google Scholar 

Senger N, Melo MB, Santos MJ, Santos RA, Barreto-Chaves ML. Angiotensin‐(1–7) prevents cardiovascular changes induced by hyperthyroidism. FASEB J. 2017;31:lb642.

Article  Google Scholar 

Papinska AM, Mordwinkin NM, Meeks CJ, Jadhav S, Rodgers KE. Angiotensin-(1–7) administration benefits cardiac, renal and progenitor cell function in db/db mice. Br J Pharmacol. 2015;172(18):4443–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi Y, Lo CS, Padda R, Abdo S, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS. Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice. Clin Sci. 2015;128(10):649–63.

Article  CAS  Google Scholar 

Amato D, Núñez-Ortiz AR, del Benítez-Flores C, Segura-Cobos J, López-Sánchez D, Vázquez-Cruz P. Role of Angiotensin-(1–7) on renal hypertrophy in Streptozotocin-Induced Diabetes Mellitus. Pharmacol Pharm. 2016;7(09):379.

Article  CAS  Google Scholar 

Shao Y, He M, Zhou L, Yao T, Huang Y, LU LM. Chronic angiotensin (1–7) injection accelerates STZ-induced diabetic renal injury 1. Acta Pharmacol Sin. 2008;29(7):829–37.

Article  CAS  PubMed  Google Scholar 

Esteban V, Heringer-Walther S, Sterner-Kock A, de Bruin R, van den Engel S, Wang Y, Mezzano S, Egido J, Schultheiss HP, Ruiz-Ortega M, Walther T. Angiotensin-(1–7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE. 2009;4(4):e5406.

Article  PubMed  PubMed Central  Google Scholar 

Zimmerman DL, Zimpelmann J, Xiao F, Gutsol A, Touyz R, Burns KD. The effect of angiotensin-(1–7) in mouse unilateral ureteral obstruction. Am J Pathol. 2015;185(3):729–40.

Article  CAS  PubMed  Google Scholar 

Papinska AM, Rodgers KE. Long-term administration of angiotensin (1–7) to db/db mice reduces oxidative stress damage in the kidneys and prevents renal dysfunction. Oxidative Med Cell Longev. 2018;2018(1):1841046.

Article  Google Scholar 

Devonshire IM, Grandy TH, Dommett EJ, Greenfield SA. Effects of urethane anaesthesia on sensory processing in the rat barrel cortex revealed by combined optical imaging and electrophysiology. Eur J Neurosci. 2010 (5):786–97.

Malatiali S, Francis I, Barac-Nieto M. Phlorizin prevents glomerular hyperfiltration but not Hypertrophy in Diabetic rats. Experimental Diabetes Res. 2008;2008:305–403.

Google Scholar 

Sabolić I, Vrhovac I, Eror DB, Gerasimova M, Rose M, Breljak D, Ljubojević M, Brzica H, Sebastiani A, Thal SC, Sauvant C. Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiology-Cell Physiol. 2012;302(8):C1174–88.

Article  Google Scholar 

Aldridge GM, Podrebarac DM, Greenough WT, Weiler IJ. The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting. J Neurosci Methods. 2008;172(2):250–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruinstroop E, van der Spek AH, Boelen A. Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis. Eur Thyroid J. 2023; 12(3).

Naguib R, Elkemary E. Thyroid dysfunction and renal function: a crucial relationship to recognize. Cureus. 2023;15(2).

Wang W, Li C, Summer SN, Falk S, Schrier RW. Polyuria of thyrotoxicosis: downregulation of aquaporin water channels and increased solute excretion. Kidney Int. 2007;72(9):1088–94.

Article  CAS  PubMed  Google Scholar 

Rodríguez-Gómez I, Sainz J, Wangensteen R, Moreno JM, Duarte J, Osuna A, Vargas F. Increased pressor sensitivity to chronic nitric oxide deficiency in hyperthyroid rats. Hypertension. 2003;42(2):220–5.

Article  PubMed  Google Scholar 

Ren Y, Garvin JL, Carretero OA. Vasodilator action of angiotensin-(1–7) on isolated rabbit afferent arterioles. Hypertension. 2002;39(3):799–802.

Article  CAS  PubMed  Google Scholar 

Sampaio WO, Nascimento AA, Santos RA. Systemic and regional hemodynamic effects of angiotensin-(1–7) in rats. Am J Physiol Heart Circ Physiol. 2003;284(6):H1985–94.

Article  CAS