Giuffrida D, Gharib H. Anaplastic thyroid carcinoma: current diagnosis and treatment. Ann Oncol. 2000;11(9):1083–90.

Article  CAS  PubMed  Google Scholar 

Chintakuntlawar AV, Foote RL, Kasperbauer JL, Bible KC. Diagnosis and management of anaplastic thyroid cancer. Endocrinol Metab Clin. 2019;48(1):269–84.

Article  Google Scholar 

Jayarangaiah A, Sidhu G, Brown J, Barrett-Campbell O, Bahtiyar G, Youssef I, et al. Therapeutic options for advanced thyroid cancer. Int J Endocrinol Metab. 2019;5(1):26.

Article  Google Scholar 

Tiedje V, Stuschke M, Weber F, Dralle H, Moss L, Führer D. Anaplastic thyroid carcinoma: review of treatment protocols. Endocr Relat Cancer. 2018;25(3):R153–61.

Article  CAS  PubMed  Google Scholar 

Maniakas A, Dadu R, Busaidy NL, Wang JR, Ferrarotto R, Lu C, et al. Evaluation of overall survival in patients with anaplastic thyroid carcinoma, 2000–2019. JAMA Oncol. 2020;6(9):1397–404.

Article  PubMed  Google Scholar 

Marei HE, Althani A, Afifi N, Hasan A, Caceci T, Pozzoli G, et al. p53 signaling in cancer progression and therapy. Cancer Cell Int. 2021;21(1):1–15.

Article  Google Scholar 

Edlund K, Larsson O, Ameur A, Bunikis I, Gyllensten U, Leroy B, et al. Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors. PNAS. 2012;109(24):9551–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang S-H, Koeffler H. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Investig. 1993;91(1):179–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer. 2009;9(10):701–13.

Article  CAS  PubMed  Google Scholar 

Wei S, Wang H, Lu C, Malmut S, Zhang J, Ren S, et al. The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins. J Biol Chem. 2014;289(13):8947–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muller PA, Vousden KH, Norman JC. p53 and its mutants in tumor cell migration and invasion. J Cell Biol. 2011;192(2):209–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee C-CR, et al. ∆Np63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res. 2003;63(10):2351–7.

CAS  PubMed  Google Scholar 

Candi E, Dinsdale D, Rufini A, Salomoni P, Knight RA, Mueller M, et al. TAp63 and ∆Np63 in cancer and epidermal development. Cell Cycle. 2007;6(3):274–84.

Article  CAS  PubMed  Google Scholar 

Sun H, Ghaffari S, Taneja R. bHLH-Orange transcription factors in development and cancer. Transl Oncogenomics. 2007;2:107.

Article  PubMed  PubMed Central  Google Scholar 

Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, et al. A mutant-p53/Smad complex opposes p63 to empower TGFβ-induced metastasis. Cell. 2009;137(1):87–98.

Article  CAS  PubMed  Google Scholar 

Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol. 2001;21(5):1874–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, et al. ATF3 suppresses metastasis of bladder Cancer by regulating gelsolin-mediated remodeling of the actin CytoskeletonATF3 suppresses the metastasis of bladder Cancer. Cancer Res. 2013;73(12):3625–37.

Article  CAS  PubMed  Google Scholar 

Jan Y-H, Tsai H-Y, Yang C-J, Huang M-S, Yang Y-F, Lai T-C, et al. Adenylate Kinase-4 is a marker of poor clinical outcomes that promotes metastasis of Lung Cancer by downregulating the transcription factor ATF3AK4 downregulates ATF3 to promote Lung Cancer Cell Metastasis. Cancer Res. 2012;72(19):5119–29.

Article  CAS  PubMed  Google Scholar 

Hackl C, Lang SA, Moser C, Mori A, Fichtner-Feigl S, Hellerbrand C, et al. Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. BMC Cancer. 2010;10:1–9.

Article  Google Scholar 

Wang H, Mo P, Ren S, Yan C. Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J Biol Chem. 2010;285(17):13201–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, et al. In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660–76.

Article  CAS  PubMed  Google Scholar 

Akbarpour Arsanjani A, Abuei H, Behzad-Behbahani A, Bagheri Z, Arabsolghar R, Farhadi A. Activating transcription factor 3 inhibits NF–κB p65 signaling pathway and mediates apoptosis and cell cycle arrest in cervical cancer cells. Infect Agents Cancer. 2022;17(1):1–10.

Article  Google Scholar 

Kooti A, Abuei H, Farhadi A, Behzad-Behbahani A, Zarrabi M. Activating transcription factor 3 mediates apoptotic functions through a p53-independent pathway in human papillomavirus 18 infected HeLa cells. Virus Genes. 2022;58(2):88–97.

Article  CAS  PubMed  Google Scholar 

Yin X, Dewille J, Hai T. A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene. 2008;27(15):2118–27.

Article  CAS  PubMed  Google Scholar 

Wu X, Nguyen B-C, Dziunycz P, Chang S, Brooks Y, Lefort K, et al. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature. 2010;465(7296):368–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao X, Chen M, Sang Y, Xue J, Jiang K, Chen Y, et al. Methylation-mediated silencing of ATF3 promotes thyroid cancer progression by regulating prognostic genes in the MAPK and PI3K/AKT pathways. Thyroid. 2023;33(12):1441–54.

Article  CAS  PubMed  Google Scholar 

Laemmli UK. Cleavage of structural proteins during the Assembly of the Head of Bacteriophage T4. Nature. 1970;227(5259):680–5.

Article  CAS  PubMed  Google Scholar 

Pfaffl MW. A new mathematical model for relative quantification in real-time RT–PCR. Nucleic Acids Res. 2001;29(9):e45–e.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guenzle J, Wolf LJ, Garrelfs NW, Goeldner JM, Osterberg N, Schindler CR, et al. ATF3 reduces migration capacity by regulation of matrix metalloproteinases via NFκB and STAT3 inhibition in glioblastoma. Cell Death Discov. 2017;3(1):1–12.

Article  Google Scholar 

Campisi A, Bonfanti R, Raciti G, Bonaventura G, Legnani L, Magro G, et al. Gene silencing of transferrin-1 receptor as a potential therapeutic target for human follicular and anaplastic thyroid cancer. Mol Ther Oncolytics. 2020;16:197–206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan C, Boyd DD. ATF3 regulates the stability of p53: a link to cancer. Cell Cycle. 2006;5(9):926–9.

Article  CA