Kaiko GE, Horvat JC, Beagley KW, Hansbro PM (2008) Immunological decision-making: how does the immune system decide to mount a helper T-cell response? Immunology 123(3):326–338. https://doi.org/10.1111/j.1365-2567.2007.02719.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson DS (2010) The role of the T cell in asthma. J Allergy Clin Immunol 126(6):1081–1091; quiz 1092–1083. https://doi.org/10.1016/j.jaci.2010.06.025

Vatrella A, Fabozzi I, Calabrese C, Maselli R, Pelaia G (2014) Dupilumab: a novel treatment for asthma. J Asthma Allergy 7:123–130. https://doi.org/10.2147/jaa.S52387

Article  PubMed  PubMed Central  Google Scholar 

McKenzie AN (2014) Type-2 innate lymphoid cells in asthma and allergy. Ann Am Thorac Soc 11(Suppl 5):S263–270. https://doi.org/10.1513/AnnalsATS.201403-097AW

Licona-Limón P, Kim LK, Palm NW, Flavell RA (2013) TH2, allergy and group 2 innate lymphoid cells. Nat Immunol 14(6):536–542. https://doi.org/10.1038/ni.2617

Article  CAS  PubMed  Google Scholar 

Wakashin H, Hirose K, Iwamoto I, Nakajima H (2009) Role of IL-23-Th17 cell axis in allergic airway inflammation. Int Arch Allergy Immunol 149(Suppl 1):108–112. https://doi.org/10.1159/000211382

Article  CAS  PubMed  Google Scholar 

Reyes NJ, Saban DR (2014) T helper subsets in allergic eye disease. Curr Opin Allergy Clin Immunol 14(5):477–484. https://doi.org/10.1097/aci.0000000000000088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng R, Yang Q (2014) The role of the gamma delta T cell in allergic diseases. J Immunol Res 2014:963484. https://doi.org/10.1155/2014/963484

Dar AA, Patil RS, Chiplunkar SV (2014) Insights into the relationship between Toll like receptors and gamma delta T cell responses. Front Immunol 5:366. https://doi.org/10.3389/fimmu.2014.00366

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shiromizu CM, Jancic CC (2018) Gammadelta T lymphocytes: an effector cell in autoimmunity and infection. Front Immunol 9:2389. https://doi.org/10.3389/fimmu.2018.02389

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamzaoui A, Kahan A, Ayed K, Hamzaoui K (2002) T cells expressing the gammadelta receptor are essential for Th2-mediated inflammation in patients with acute exacerbation of asthma. Mediators Inflamm 11(2):113–119. https://doi.org/10.1080/09629350220131971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ribot JC, Lopes N, Silva-Santos B (2020) Gammadelta T cells in tissue physiology and surveillance. Nat Rev Immunol. https://doi.org/10.1038/s41577-020-00452-4

Article  PubMed  Google Scholar 

Pang DJ, Neves JF, Sumaria N, Pennington DJ (2012) Understanding the complexity of gammadelta T-cell subsets in mouse and human. Immunol 136(3):283–290. https://doi.org/10.1111/j.1365-2567.2012.03582.x

Article  CAS  Google Scholar 

Kabelitz D, Marischen L, Oberg HH, Holtmeier W, Wesch D (2005) Epithelial defence by γδ T cells. Int Arch Allergy Immunol 137(1):73–81. https://doi.org/10.1159/000085107

Article  CAS  PubMed  Google Scholar 

Pauza CD, Liou M-L, Lahusen T, Xiao L, Lapidus RG, Cairo C, Li H (2018) Gamma delta T cell therapy for cancer: it is good to be local. Front Immunol 9(1305). https://doi.org/10.3389/fimmu.2018.01305

Wands JM, Roark CL, Aydintug MK, Jin N, Hahn YS, Cook L, Yin X, Dal Porto J, Lahn M, Hyde DM et al (2005) Distribution and leukocyte contacts of gammadelta T cells in the lung. J Leukoc Biol 78(5):1086–1096. https://doi.org/10.1189/jlb.0505244

Article  CAS  PubMed  Google Scholar 

Krug N, Erpenbeck JV, Balke K, Petschallies J, Tschernig T, Hohlfeld JM, Fabel H (2001) Cytokine profile of bronchoalveolar lavage–derived CD4, CD8, and T cells in people with asthma after segmental allergen challenge. Am J Respir Cell Mol Biol 25:125–131. https://doi.org/10.1165/ajrcmb.25.1.4194

Article  CAS  PubMed  Google Scholar 

Glanville N, Message SD, Walton RP, Pearson RM, Parker HL, Laza-Stanca V, Mallia P, Kebadze T, Contoli M, Kon OM et al (2013) GammadeltaT cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations. Mucosal Immunol 6(6):1091–1100. https://doi.org/10.1038/mi.2013.3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russano AM, Agea E, Corazzi L, Postle AD, De Libero G, Porcelli S, de Benedictis FM, Spinozzi F (2006) Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells. J Allergy Clin Immunol 117(5):1178–1184. https://doi.org/10.1016/j.jaci.2006.01.001

Article  CAS  PubMed  Google Scholar 

Yang LY, Li X, Li WT, Huang JC, Wang ZY, Huang ZZ, Chang LH, Zhang GH (2017) Vgamma1(+) gammadeltaT cells are correlated with increasing expression of eosinophil cationic protein and metalloproteinase-7 in chronic rhinosinusitis with nasal polyps inducing the formation of edema. Allergy Asthma Immunol Res 9(2):142–151. https://doi.org/10.4168/aair.2017.9.2.142

Article  CAS  PubMed  Google Scholar 

Reyes NJ, Mayhew E, Chen PW, Niederkorn JY (2011) gammadelta T cells are required for maximal expression of allergic conjunctivitis. Invest Ophthalmol Vis Sci 52(5):2211–2216. https://doi.org/10.1167/iovs.10-5959

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mengel J, Cardillo F, Aroeira LS, Williams O, Russo M, Vaz NM (1995) Anti-gamma delta T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice. Immunol Lett 48(2):97–102

Article  CAS  PubMed  Google Scholar 

Bol-Schoenmakers M, Marcondes Rezende M, Bleumink R, Boon L, Man S, Hassing I, Fiechter D, Pieters RH, Smit JJ (2011) Regulation by intestinal gammadelta T cells during establishment of food allergic sensitization in mice. Allergy 66(3):331–340. https://doi.org/10.1111/j.1398-9995.2010.02479.x

Article  CAS  PubMed  Google Scholar 

Hayday AC, Vantourout P (2020) The innate biologies of adaptive antigen receptors. Annu Rev Immunol 38:487–510. https://doi.org/10.1146/annurev-immunol-102819-023144

Article  CAS  PubMed  Google Scholar 

Abeler-Dörner L, Swamy M, Williams G, Hayday AC, Bas A (2012) Butyrophilins: an emerging family of immune regulators. Trends Immunol 33(1):34–41. https://doi.org/10.1016/j.it.2011.09.007

Article  CAS  PubMed  Google Scholar 

Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP (2008) Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Nat Genet 40(5):656–662. https://doi.org/10.1038/ng.108

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sutoh Y, Mohamed RH, Kasahara M (2018) Origin and evolution of dendritic epidermal T cells. Front Immunol 9:1059. https://doi.org/10.3389/fimmu.2018.01059

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML et al (2016) Epithelia use butyrophilin-like molecules to shape organ-specific gammadelta T cell compartments. Cell 167(1):203–218 e217. https://doi.org/10.1016/j.cell.2016.08.030

Melandri D, Zlatareva I, Chaleil RAG, Dart RJ, Chancellor A, Nussbaumer O, Polyakova O, Roberts NA, Wesch D, Kabelitz D et al (2018) The gammadeltaTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness. Nat Immunol 19(12):1352–1365. https://doi.org/10.1038/s41590-018-0253-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willcox CR, Vantourout P, Salim M, Zlatareva I, Melandri D, Zanardo L, George R, Kjaer S, Jeeves M, Mohammed F et al (2019) Butyrophilin-like 3 Directly binds a human Vγ4(+) T cell receptor using a modality distinct from clonally-restricted antigen. Immunity 51(5):813–825.e814. https://doi.org/10.1016/j.immuni.2019.09.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharp LL, Jameson JM, Cauvi G, Havran WL (2005) Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1. Nat Immunol 6(1):73–79. https://doi.org/10.1038/ni1152

Article  CAS  PubMed  Google Scholar 

Strid J, Sobolev O, Zafirova B, Polic B, Hayday A (2011) The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. Sci 334(6060):1293–1297. https://doi.org/10.1126/science.1211250

Article  CAS  Google Scholar 

Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M (2008) Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nat Immunol 9(2):146–154. https://doi.org/10.1038/ni1556

Article  CAS  PubMed  Google Scholar 

Toulon A, Breton L, Taylor KR, Tenenhaus M, Bhavsar D, Lanigan C, Rudolph R, Jameson J, Havran WL (2009) A role for human skin-resident T cells in wound healing. J Exp Med 206(4):743–750. https://doi.org/10.1084/jem.20081787

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H (1995) Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature (London) 373(6511):255–257

Article  CAS  PubMed  Google Scholar 

Wesch D, Glatzel A, Kabelitz D (2001) Differentiation of resting human peripheral blood gamma delta T cells toward Th1- or Th2-phenotype. Cell Immunol 212(2):110–117. https://doi.org/10.1006/cimm.2001.1850

Article  CAS  PubMed  Google Scholar 

Zhang L, Liu J, Wang E, Wang B, Zeng S, Wu J, Kimura Y, Liu B (2013) Respiratory syncytial virus protects against the subsequent development of ovalbumin-induced allergic responses by inhibiting Th2-type gammadelta T cells. J Med Virol 85(1):149–156. https://doi.org/10.1002/jmv.23435