Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders

Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, et al. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proc Natl Acad Sci USA. 1996;93(15):8072–7. https://doi.org/10.1073/pnas.93.15.8072.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayashi T, Su TP. σ-1 Receptors (σ1 binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export. J Pharmacol Exp Ther. 2003;306(2):718–25. https://doi.org/10.1124/jpet.103.051284.

Article  CAS  PubMed  Google Scholar 

Hayashi T, Su TP. Regulating ankyrin dynamics: roles of sigma-1 receptors. Proc Natl Acad Sci USA. 2001;98(2):491–6. https://doi.org/10.1073/pnas.021413698.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kinoshita M, Matsuoka Y, Suzuki T, Mirrielees J, Yang J. Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands. Brain Res. 2012;1452:1–9. https://doi.org/10.1016/j.brainres.2012.02.070.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, et al. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Sci Rep. 2020;10(1):9251. https://doi.org/10.1038/s41598-020-65849-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brimson JM, Brown CA, Safrany ST. Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol. 2011;164(2B):772–80. https://doi.org/10.1111/j.1476-5381.2011.01417.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Natsvlishvili N, Goguadze N, Zhuravliova E, Mikeladze D. Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria. BMC Biochem. 2015;16(1):1–7. https://doi.org/10.1186/s12858-015-0040-y.

Article  CAS  Google Scholar 

Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, Ruoho AE. The hallucinogen N, N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science. 2009;323(5916):934–7. https://doi.org/10.1126/science.1166127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayashi T, Su TP. Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs. 2004;18(5):269–84. https://doi.org/10.2165/00023210-200418050-00001.

Article  CAS  PubMed  Google Scholar 

Ruoho AE, Chu UB, Ramachandran S, Fontanilla D, Mavlyutov T, Hajipour AR. The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. Curr Pharm Des. 2012;18(7):920–9. https://doi.org/10.2174/138161212799436584.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vavers E, Zvejniece L, Maurice T, Dambrova M. Allosteric modulators of sigma-1 receptor: a review. Front Pharmacol. 2019;10:223. https://doi.org/10.3389/fphar.2019.00223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayashi T, Su TP. The sigma receptor: evolution of the concept in neuropsychopharmacology. Curr Neuropharmacol. 2005;3(4):267–80. https://doi.org/10.2174/157015905774322516.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quirion R, Chicheportiche R, Contreras PC, Johnson KM, Lodge D, Tam SW, et al. Classification and nomenclature of phencyclidine and sigma receptor sites. Trends Neurosci. 1987;10(11):444–6. https://doi.org/10.1016/0166-2236(87)90094-4.

Article  CAS  Google Scholar 

Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MVL, O’Neill M, et al. Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res. 2004;64(14):4875–86. https://doi.org/10.1158/0008-5472.CAN-03-3180.

Article  CAS  PubMed  Google Scholar 

Wang L, Prescott AR, Spruce BA, Sanderson J, Duncan G. Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation. Invest Ophthalmol Vis Sci. 2005;46(4):1403–8. https://doi.org/10.1167/iovs.04-1209.

Article  PubMed  Google Scholar 

Hayashi T, Su TP. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival. Cell. 2007;131(3):596–610. https://doi.org/10.1016/j.cell.2007.08.036.

Article  CAS  PubMed  Google Scholar 

Hellewell SB, Bruce A, Feinstein G, Orringer J, Williams W, Bowen WD. Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling. Eur J Pharmacol. 1994;268(1):9–18. https://doi.org/10.1016/0922-4106(94)90115-5.

Article  CAS  PubMed  Google Scholar 

Wolfe SA Jr, Culp SG, De Souza EB. σ-Receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary. Endocrinology. 1989;124(3):1160–72. https://doi.org/10.1210/endo-124-3-1160.

Article  CAS  PubMed  Google Scholar 

Borde P, Cosgrove N, Charmsaz S, Safrany ST, Young L. An investigation of Sigma-1 receptor expression and ligand-induced endoplasmic reticulum stress in breast cancer. Cancer Gene Ther. 2023;30(2):368–74. https://doi.org/10.1038/s41417-022-00552-4.

Article  CAS  PubMed  Google Scholar 

Huang YS, Lu HL, Zhang LJ, Wu Z. Sigma-2 receptor ligands and their perspectives in cancer diagnosis and therapy. Med Res Rev. 2014;34(3):532–66. https://doi.org/10.1002/med.21297.

Article  CAS  PubMed  Google Scholar 

Nicholson H, Mesangeau C, McCurdy CR, Bowen WD. Sigma-2 receptors play a role in cellular metabolism: stimulation of glycolytic hallmarks by CM764 in human SK-N-SH neuroblastoma. J Pharmacol Exp Ther. 2016;356(2):232–43. https://doi.org/10.1124/jpet.115.228387.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rousseaux CG, Greene SF. Sigma receptors [σRs]: biology in normal and diseased states. J Recept Signal Transduct Res. 2016;36(4):327–88. https://doi.org/10.3109/10799893.2015.1015737.

Article  CAS  PubMed  Google Scholar 

Liu C, Yu CF, Wang SC, Li HY, Lin CM, Wang HH, et al. Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor. BMC Cancer. 2019;19(1):473. https://doi.org/10.1186/s12885-019-5700-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang K, Wang C, Sun T. The roles of intracellular chaperone proteins, sigma receptors, in Parkinson’s disease (PD) and major depressive disorder (MDD). Front Pharmacol. 2019;10:528. https://doi.org/10.3389/fphar.2019.00528.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Georgiadis MO, Karoutzou O, Foscolos AS, Papanastasiou I. Sigma receptor (σR) ligands with antiproliferative and anticancer activity. Molecules. 2017;22:9. https://doi.org/10.3390/molecules22091408.

Article  CAS  Google Scholar 

Gebreselassie D, Bowen WD. Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes. Eur J Pharmacol. 2004;493(1–3):19–28. https://doi.org/10.1016/j.ejphar.2004.04.005.

Article  CAS  PubMed  Google Scholar 

Munro S. Lipid rafts: elusive or illusive? Cell. 2003;115(4):377–88. https://doi.org/10.1016/S0092-8674(03)00882-1.

Article  CAS  PubMed  Google Scholar 

Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O’Meara MJ, et al. Structures of the σ2 receptor enable docking for bioactive ligand discovery. Nature. 2021;600(7890):759–64. https://doi.org/10.1038/s41586-021-04175-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Terada K, Migita K, Matsushima Y, Kamei C. Sigma-2 receptor as a potential therapeutic target for treating central nervous system disorders. Neural Regen Res. 2019;14(11):1893–4. https://doi.org/10.4103/1673-5374.259609.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abate C, Niso M, Berardi F. Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations. Future Med Chem. 2018;10(16):1997–2018. https://doi.org/10.4155/fmc-2018-0072.

Article  CAS  PubMed  Google Scholar 

Cantonero C, Camello PJ, Abate C, Berardi F, Salido GM, Rosado JA, et al. NO1, a new Sigma 2 receptor/TMEM97 fluorescent ligand, downregulates SOCE and promotes apoptosis in the triple negative breast cancer cell lines. Cancers (Basel). 2020;12(2):257. https://doi.org/10.3390/cancers12020257.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng C, Vangveravong S, McDunn JE, Hawkins WG, Mach RH. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. Br J Cancer. 2013;109(9):2368–77. https://doi.org/10.1038/bjc.2013.593.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng C, Riad A, Mach RH. The biological function of Sigma-2 receptor/TMEM97 and its utility in PET imaging studies in cancer. Cancers (Basel). 2020;12(7):1877. https://doi.org/10.3390/cancers12071877.

Article  CAS 

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