Kassebaum NJ, Barber RM, Bhutta ZA, Dandona L, Gething PW, Hay SI, et al. Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016;388(10053):1775–812.
Wang H, Bhutta ZA, Coates MM, Coggeshall M, Dandona L, Diallo K, et al. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016;388(10053):1725–74.
Lowe SA, Bowyer L, Lust K, McMahon LP, Morton M, North RA, et al. SOMANZ guidelines for the management of hypertensive disorders of pregnancy 2014. Aust N Z J Obstet Gynaecol. 2015;55(5):e1–29.
•• Magee LA, Nicolaides KH, Von Dadelszen P. Preeclampsia. N Engl J Med. 2022;386(19):1817–32. This article clinically defines PE and provides an in-depth review of the current findings in PE research.
Article CAS PubMed Google Scholar
Ma’ayeh M, Rood KM, Kniss D, Costantine MM. Novel interventions for the prevention of preeclampsia. Curr Hypertens Rep. 2020;22(2):1–8.
Sones JL, Cha J, Woods AK, Bartos A, Heyward CY, Lob HE, et al. Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model. JCI insight. 2016;1(3).
Roberts JM, editor Pathophysiology of ischemic placental disease. Semin Perinatol; 2014: Elsevier.
Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP, et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab. 2004;89(2):770–5.
Article CAS PubMed Google Scholar
Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123(24):2856–69.
Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension. 2018;72(1):24–43.
Article CAS PubMed Google Scholar
Aneman I, Pienaar D, Suvakov S, Simic TP, Garovic VD, McClements L. Mechanisms of key innate immune cells in early- and late-onset preeclampsia. Front Immunol. 2020;11:1864.
Article CAS PubMed PubMed Central Google Scholar
Huppertz B. The critical role of abnormal trophoblast development in the etiology of preeclampsia. Curr Pharm Biotechnol. 2018;19(10):771–80.
Article CAS PubMed PubMed Central Google Scholar
Phipps E, Prasanna D, Brima W, Jim B. Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clin J Am Soc Nephrol. 2016;11(6):1102–13.
Article CAS PubMed PubMed Central Google Scholar
Rolnik DL, Wright D, Poon LC, O’Gorman N, Syngelaki A, de Paco MC, et al. Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med. 2017;377(7):613–22.
Article CAS PubMed Google Scholar
Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S, et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol. 2010;116(2):402–14.
Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: a guideline from the American Heart Association. Circulation. 2011;123(11):1243–62.
Article PubMed PubMed Central Google Scholar
Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(5):1545–88.
•• Gatford KL, Andraweera PH, Roberts CT, Care AS. Animal models of preeclampsia: causes, consequences, and interventions. Hypertension. 2020;75(6):1363–81. This article reviews the current published preclinical models of PE that are consistent with human clinical criteria.
Article CAS PubMed Google Scholar
Alexander BT, Kassab SE, Miller MT, Abram SR, Reckelhoff JF, Bennett WA, et al. Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide. Hypertension. 2001;37(4):1191–5.
Article CAS PubMed Google Scholar
Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol. 2002;283(1):R29–45.
Article CAS PubMed Google Scholar
LaMarca B, Amaral LM, Harmon AC, Cornelius DC, Faulkner JL, Cunningham MW. Placental ischemia and resultant phenotype in animal models of preeclampsia. Curr Hypertens Rep. 2016;18(5):1–9.
Ramesar S, Mackraj I, Gathiram P, Moodley J. Sildenafil citrate decreases sFlt-1 and sEng in pregnant L-NAME treated Sprague-Dawley rats. Eur J Obstet Gynecol Reprod Biol. 2011;157(2):136–40.
•• Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, et al. Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model. Hypertension. 2014;64(4):852–9. This article demonstrates that chronic administration of AVP during pregnancy induces human PE-like phenotypes in mice.
Article CAS PubMed Google Scholar
Doridot L, Passet B, Méhats C, Barbaux S, Mondon F, Vilotte M, et al. STOX1 overexpression in mice induces severe preeclampsia-like symptoms prevented by aspirin at low doses. J Reprod Immunol. 2012;1(94):6–7.
•• Maynard SE, Min J-Y, Merchan J, Lim K-H, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Investig. 2003;111(5):649–58. This article measured serum sFlt-1 levels in preeclamptic women and determined that sFlt1 infusion sufficiently reproduces clinical aspects of preeclampsia in rats.
Article CAS PubMed PubMed Central Google Scholar
Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, et al. Pregnant mice lacking indoleamine 2, 3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep. 2015;3(1):e12257.
Article PubMed PubMed Central Google Scholar
Nishizawa H, Hasegawa K, Suzuki M, Achiwa Y, Kato T, Saito K, et al. Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. J Obstet Gynaecol Res. 2008;34(1):1–6.
Gillis EE, Williams JM, Garrett MR, Mooney JN, Sasser JM. The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia. Am J Physiol - Regul Integr Comp Physiol. 2015;309(1):R62–70.
Article CAS PubMed PubMed Central Google Scholar
Davisson RL, Hoffmann DS, Butz GM, Aldape G, Schlager G, Merrill DC, et al. Discovery of a spontaneous genetic mouse model of preeclampsia. Hypertension. 2002;39(2):337–42.
Article CAS PubMed Google Scholar
Cushen SC, Goulopoulou S. New models of pregnancy-associated hypertension. Am J Hypertens. 2017;30(11):1053–62.
Article CAS PubMed Google Scholar
•• Bakrania BA, George EM, Granger JP. Animal models of preeclampsia: investigating pathophysiology and therapeutic targets. Am J Obstet Gynecol. 2021. This article provides a comprehensive review of the most widely studied and novel animal models created to study PE.
Soobryan N, Murugesan S, Phoswa W, Gathiram P, Moodley J, Mackraj I. The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia. Eur J Pharmacol. 2017;795:101–7.
Article CAS PubMed Google Scholar
Doridot L, Delpoux A, Lucas B, Vaiman D. Preeclampsia-like syndrome in STOX1 overexpressing mice: defects in immune regulation?: P-134. Am J Reprod Immunol. 2013;69:127–8.
Ho L, Van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, et al. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017;357(6352):707–13.
Article CAS PubMed Google Scholar
Makris A, Thornton C, Thompson J, Thomson S, Martin R, Ogle R, et al. Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1. Kidney Int. 2007;71(10):977–84.
Article CAS PubMed Google Scholar
Baijnath S, Soobryan N, Mackraj I, Gathiram P, Moodley J. The optimization of a chronic nitric oxide synthase (NOS) inhibition model of pre-eclampsia by evaluating physiological changes. Eur J Obstet Gynecol Reprod Biol. 2014;182:71–5.
NICE. Pre-eclampsia. Hypertens Pregnancy [Internet]. 2021 30 October 2021:[1–21 pp.]. Available from: http://pathways.nice.org.uk/pathways/hypertension-in-pregnancy.
Salahuddin S, Wenger JB, Zhang D, Thadhani R, Karumanchi SA, Rana S. KRYPTOR-automated angiogenic factor assays and risk of preeclampsia-related adverse outcomes. Hypertens Pregnancy. 2016;35(3):330–45.
Article CAS PubMed Google Scholar
• Andersen LLT, Helt A, Sperling L, Overgaard M. Decision threshold for Kryptor sFlt-1/PlGF ratio in women with suspected preeclampsia: retrospective study in a routine clinical setting. J Am Heart Assoc. 2021;10(17):e021376. This article investigates the diagnostic ability of the BRAHMS Kryptor sFlt-1 and PlGF assays.
Article CAS PubMed PubMed Central Google Scholar
Clark DA. The use and misuse of animal analog models of human pregnancy disorders. J Reprod Immunol. 2014;103:1–8.
Article CAS PubMed Google Scholar
El-Hashash AH, Warburton D, Kim
留言 (0)