HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments

Avettand-Fenoel V, Hocqueloux L, Ghosn J, Cheret A, Frange P, Melard A, Viard JP, Rouzioux C. Total HIV-1 DNA, a marker of viral reservoir dynamics with clinical implications. Clin Microbiol Rev. 2016;29:859–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaillon A, Gianella S, Dellicour S, Rawlings SA, Schlub TE, De Oliveira MF, Ignacio C, Porrachia M, Vrancken B, Smith DM. HIV persists throughout deep tissues with repopulation from multiple anatomical sources. J Clin Invest. 2020;130:1699–712.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rao TK, Filippone EJ, Nicastri AD, Landesman SH, Frank E, Chen CK, Friedman EA. Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N Engl J Med. 1984;310:669–73.

Article  CAS  PubMed  Google Scholar 

Kopp JB, Klotman ME, Adler SH, Bruggeman LA, Dickie P, Marinos NJ, Eckhaus M, Bryant JL, Notkins AL, Klotman PE. Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci U S A. 1992;89:1577–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruggeman LA, Ross MD, Tanji N, Cara A, Dikman S, Gordon RE, Burns GC, D’Agati VD, Winston JA, Klotman ME, Klotman PE. Renal epithelium is a previously unrecognized site of HIV-1 infection. J Am Soc Nephrol. 2000;11:2079–87.

Article  PubMed  Google Scholar 

Marras D, Bruggeman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D’Agati VD, et al. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med. 2002;8:522–6.

Article  CAS  PubMed  Google Scholar 

Canaud G, Dejucq-Rainsford N, Avettand-Fenoel V, Viard JP, Anglicheau D, Bienaime F, Muorah M, Galmiche L, Gribouval O, Noel LH, et al. The kidney as a reservoir for HIV-1 after renal transplantation. J Am Soc Nephrol. 2014;25:407–19.

Article  PubMed  Google Scholar 

Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J, Davis C, Blumberg E, Simon D, Subramanian A, et al. Outcomes of kidney transplantation in HIV-infected recipients. N Engl J Med. 2010;363:2004–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karris MA, Smith DM. Tissue-specific HIV-1 infection: why it matters. Future Virol. 2011;6:869–82.

Article  PubMed  PubMed Central  Google Scholar 

Nickle DC, Jensen MA, Shriner D, Brodie SJ, Frenkel LM, Mittler JE, Mullins JI. Evolutionary indicators of human immunodeficiency virus type 1 reservoirs and compartments. J Virol. 2003;77:5540–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nickle DC, Shriner D, Mittler JE, Frenkel LM, Mullins JI. Importance and detection of virus reservoirs and compartments of HIV infection. Curr Opin Microbiol. 2003;6:410–6.

Article  PubMed  Google Scholar 

Blasi M, Carpenter JH, Balakumaran B, Cara A, Gao F, Klotman ME. Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine. AIDS. 2015;29:1651–7.

Article  CAS  PubMed  Google Scholar 

Blasi M, Stadtler H, Chang J, Hemmersbach-Miller M, Wyatt C, Klotman P, Gao F, Wolfe C, Klotman M. Detection of dDonor’s HIV strain in HIV-positive kidney-transplant recipient. N Engl J Med. 2020;382:195–7.

Article  PubMed  PubMed Central  Google Scholar 

Mallipattu SK, Liu R, Zhong Y, Chen EY, D’Agati V, Kaufman L, Ma’ayan A, Klotman PE, Chuang PY, He JC. Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney Int. 2013;83:626–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stadtler H, Wescott E, Hughes K, Chang J, Gao F, Klotman M, Blasi M. HIV-1 diversity and compartmentalization in urine, semen, and blood. Medicine (Baltimore). 2020;99: e23063.

Article  CAS  PubMed  Google Scholar 

Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, Spindler J, Ferris AL, Mellors JW, Kearney MF, et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science. 2014;345:179–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wagner TA, McLaughlin S, Garg K, Cheung CY, Larsen BB, Styrchak S, Huang HC, Edlefsen PT, Mullins JI, Frenkel LM. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science. 2014;345:570–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Health Resources and Services Administration (HRSA), Department of Health and Human Services (HHS). Organ procurement and transplantation: implementation of the HIV Organ Policy Equity Act. Final rule. Fed Regist. 2015;80:26464–7.

Google Scholar 

Chen P, Hubner W, Spinelli MA, Chen BK. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J Virol. 2007;81:12582–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hubner W, McNerney GP, Chen P, Dale BM, Gordon RE, Chuang FY, Li XD, Asmuth DM, Huser T, Chen BK. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science. 2009;323:1743–7.

Article  PubMed  PubMed Central  Google Scholar 

Mulherkar TH, Gomez DJ, Sandel G, Jain P. Co-infection and cancer: host-pathogen interaction between dendritic cells and HIV-1, HTLV-1, and other oncogenic viruses. Viruses. 2022;14:2037.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen P, Chen BK, Mosoian A, Hays T, Ross MJ, Klotman PE, Klotman ME. Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. J Am Soc Nephrol. 2011;22:496–507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blasi M, Balakumaran B, Chen P, Negri DR, Cara A, Chen BK, Klotman ME. Renal epithelial cells produce and spread HIV-1 via T-cell contact. AIDS. 2014;28:2345–53.

Article  CAS  PubMed  Google Scholar 

Hughes K, Akturk G, Gnjatic S, Chen B, Klotman M, Blasi M. Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages. AIDS. 2020;34:1581–91.

Article  CAS  PubMed  Google Scholar 

Bruggeman LA, Dikman S, Meng C, Quaggin SE, Coffman TM, Klotman PE. Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Invest. 1997;100:84–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Husain M, Gusella GL, Klotman ME, Gelman IH, Ross MD, Schwartz EJ, Cara A, Klotman PE. HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes. J Am Soc Nephrol. 2002;13:1806–15.

Article  CAS  PubMed  Google Scholar 

Husain M, D’Agati VD, He JC, Klotman ME, Klotman PE. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS. 2005;19:1975–80.

Article  CAS  PubMed  Google Scholar 

Payne EH, Ramalingam D, Fox DT, Klotman ME. Polyploidy and mitotic cell death are two distinct HIV-1 Vpr-driven outcomes in renal tubule epithelial cells. J Virol. 2018;92: e01718.

Article  PubMed  PubMed Central  Google Scholar 

Rosenstiel PE, Gruosso T, Letourneau AM, Chan JJ, LeBlanc A, Husain M, Najfeld V, Planelles V, D’Agati VD, Klotman ME, Klotman PE. HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. Kidney Int. 2008;74:1049–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Chen Y, Fu J, Sun Z, Li H, Xiao W, Jing E, Lo BY, Wang N, Zhang W, et al. Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development. Kidney Int. 2023;103:529–43.

Article  CAS  PubMed  Google Scholar 

Shrivastav S, Lee H, Okamoto K, Lu H, Yoshida T, Latt KZ, Wakashin H, Dalgleish JLT, Koritzinsky EH, Xu P, et al. HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule. PLoS ONE. 2022;17: e0273313.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I. HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. J Am Soc Nephrol. 2006;17:2832–43.

Article  CAS  PubMed  Google Scholar 

Reeves DB, Duke ER, Wagner TA, Palmer SE, Spivak AM, Schiffer JT. A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation. Nat Commun. 2018;9:4811.

Article  PubMed  PubMed Central  Google Scholar 

Andrianova NV, Buyan MI, Zorova LD, Pevzner IB, Popkov VA, Babenko VA, Silachev DN, Plotnikov EY, Zorov DB. Kidney cells reg

留言 (0)

沒有登入
gif