Rocco ML, Soligo M, Manni L, Aloe L. Nerve growth factor: early studies and recent clinical trials. Curr Neuropharmacol. 2018;16:1455–65. https://doi.org/10.2174/1570159X16666180412092859.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999;401:184–8. https://doi.org/10.1038/43705.

Article  CAS  PubMed  Google Scholar 

Nguyen N, Lee SB, Lee YS, Lee KH, Ahn JY. Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res. 2009;34:942–51. https://doi.org/10.1007/s11064-008-9848-9.

Article  CAS  PubMed  Google Scholar 

Aloe L, Rocco ML, Bianchi P, Manni L. Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med. 2012;10:239. https://doi.org/10.1186/1479-5876-10-239.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia TB, Hollborn M, Bringmann A. Expression and signaling of NGF in the healthy and injured retina. Cytokine Growth Factor Rev. 2017;34:43–57. https://doi.org/10.1016/j.cytogfr.2016.11.005.

Article  CAS  PubMed  Google Scholar 

Li R, Li D, Wu C, Ye L, Wu Y, Yuan Y, et al. Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. Theranostics. 2020;10:1649–77. https://doi.org/10.7150/thno.40919.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alastra G, Aloe L, Baldassarro VA, Calzà L, Cescatti M, Duskey JT, et al. Nerve growth factor biodelivery: a limiting step in moving toward extensive clinical application. Front Neurosci. 2021;15: 695592. https://doi.org/10.3389/fnins.2021.695592.

Article  PubMed  PubMed Central  Google Scholar 

Kanu LN, Ciolino JB. Nerve growth factor as an ocular therapy: applications, challenges, and future directions. Semin Ophthalmol. 2021;36:224–31. https://doi.org/10.1080/08820538.2021.1890793.

Article  PubMed  PubMed Central  Google Scholar 

Xu L, Li Y, Shi X, Han C, Tao L, Yang Q, et al. Expression, purification, and characterization of recombinant mouse nerve growth factor in Chinese hamster ovary cells. Protein Expr Purif. 2014;104:41–9. https://doi.org/10.1016/j.pep.2014.09.007.

Article  CAS  PubMed  Google Scholar 

Liu YR, Liu Q. Meta-analysis of mNGF therapy for peripheral nerve injury: a systematic review. Chin J Traumatol. 2012;15:86–91.

PubMed  Google Scholar 

Li JT, Dong SQ, Qian T, Yang WB, Chen XJ. Mouse nerve growth factor injection and progression rate in patients with amyotrophic lateral sclerosis: an observational study. Front Neurol. 2022;13: 829569. https://doi.org/10.3389/fneur.2022.829569.

Article  PubMed  PubMed Central  Google Scholar 

Zhao M, Li XY, Xu CY, Zou LP. Efficacy and safety of nerve growth factor for the treatment of neurological diseases: a meta-analysis of 64 randomized controlled trials involving 6,297 patients. Neural Regen Res. 2015;10:819–28. https://doi.org/10.4103/1673-5374.156989.

Article  PubMed  PubMed Central  Google Scholar 

An S, Jia Y, Tian Y, Sun J, Wei Y, Yue S, et al. Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: a proof-of-concept study. J Neurol Sci. 2020;418: 117069. https://doi.org/10.1016/j.jns.2020.117069.

Article  CAS  PubMed  Google Scholar 

Pei LN, Liu XH, Zhang H, Zhu J, Gao Z, Bi MZ. Clinical efficacy of mouse nerve growth factor plus nimodipine in neonatal intracranial hemorrhage and its effect on plasma PAF, CNP, MMP-2, and neurological function. Eur Rev Med Pharmacol Sci. 2021;25:215–21. https://doi.org/10.26355/eurrev_202101_24387.

Article  PubMed  Google Scholar 

Kakihana M, Kato K, Fukumoto H, Fujiwara E, Iwane M, Suno M. Detailed characterization of the biological activities of recombinant human nerve growth factor expressed in Chinese hamster ovary cells. Mol Chem Neuropathol. 1993;18:51–83. https://doi.org/10.1007/BF03160022.

Article  CAS  PubMed  Google Scholar 

Weissmiller AM, Wu C. Current advances in using neurotrophic factors to treat neurodegenerative disorders. Transl Neurodegener. 2012;1:14. https://doi.org/10.1186/2047-9158-1-14.

Article  PubMed  PubMed Central  Google Scholar 

Faustino C, Rijo P, Reis CP. Nanotechnological strategies for nerve growth factor delivery: therapeutic implications in Alzheimer’s disease. Pharmacol Res. 2017;120:68–87. https://doi.org/10.1016/j.phrs.2017.03.020.

Article  CAS  PubMed  Google Scholar 

Gudasheva TA, Povarnina PY, Tarasiuk AV, Seredenin SB. Low-molecular mimetics of nerve growth factor and brain-derived neurotrophic factor: design and pharmacological properties. Med Res Rev. 2021;41:2746–74. https://doi.org/10.1002/med.21721.

Article  CAS  PubMed  Google Scholar 

Tria MA, Fusco M, Vantini G, Mariot R. Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats. Exp Neurol. 1994;127:178–83. https://doi.org/10.1006/exnr.1994.1093.

Article  CAS  PubMed  Google Scholar 

Nguyen CB, Harris L, Szönyi E, Baughman SA, Hale VG, Dybdal NO, Sadick MD, Escandón E. Tissue disposition and pharmacokinetics of recombinant human nerve growth factor after acute and chronic subcutaneous administration in monkeys. Drug Metab Dispos. 2000;28:598–607.

CAS  PubMed  Google Scholar 

Ferrari MP, Mantelli F, Sacchetti M, Antonangeli MI, Cattani F, D’Anniballe G, et al. Safety and pharmacokinetics of escalating doses of human recombinant nerve growth factor eye drops in a double-masked, randomized clinical trial. BioDrugs. 2014;28:275–83. https://doi.org/10.1007/s40259-013-0079-5.

Article  CAS  PubMed  Google Scholar 

Ossipov MH. Growth factors and neuropathic pain. Curr Pain Headache Rep. 2011;15:185–92. https://doi.org/10.1007/s11916-011-0183-5.

Article  PubMed  Google Scholar 

Khan N, Smith MT. Neurotrophins and neuropathic pain: role in pathobiology. Molecules. 2015;20:10657–88. https://doi.org/10.3390/molecules200610657.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Apfel SC, Schwartz S, Adornato BT, Freeman R, Biton V, Rendell M, et al. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: a randomized controlled trial. rhNGF Clinical Investigator Group. JAMA. 2000;284:2215–21. https://doi.org/10.1001/jama.284.17.2215.

Article  CAS  PubMed  Google Scholar 

Dhahri R, Athimni S, Slouma M, Metoui L, Gharsallah I, Louzir B. Anti-drug antibodies monitoring in biologics use: clinical implications. Curr Rev Clin Exp Pharmacol. 2021;16:235–8. https://doi.org/10.2174/1574884715666200917102055.

Article  CAS  PubMed  Google Scholar 

Petty BG, Cornblath DR, Adornato BT, Chaudhry V, Flexner C, Wachsman M, et al. The effect of systemically administered recombinant human nerve growth factor in healthy human subjects. Ann Neurol. 1994;36:244–6. https://doi.org/10.1002/ana.410360221.

Article  CAS  PubMed  Google Scholar 

Ludden TM. Nonlinear pharmacokinetics: clinical Implications. Clin Pharmacokinet. 1991;20:429–46. https://doi.org/10.2165/00003088-199120060-00001.

Article  CAS  PubMed  Google Scholar 

Beykin G, Stell L, Halim MS, Nuñez M, Popova L, Nguyen BT, et al. Phase 1b randomized controlled study of short course topical recombinant human nerve growth factor (rhNGF) for neuroenhancement in glaucoma: safety, tolerability, and efficacy measure outcomes. Am J Ophthalmol. 2022;234:223–34. https://doi.org/10.1016/j.ajo.2021.11.002.

Article  CAS  PubMed  Google Scholar 

Colangelo AM, Finotti N, Ceriani M, Alberghina L, Martegani E, Aloe L, et al. Recombinant human nerve growth factor with a marked activity in vitro and in vivo. Proc Natl Acad Sci USA. 2005;102:18658–63. https://doi.org/10.1073/pnas.0508734102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Apfel SC. Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold. Int Rev Neurobiol. 2002;50:393–413. https://doi.org/10.1016/s0074-7742(02)50083-0.

Article  CAS  PubMed  Google Scholar 

Guo L, Davis BM, Ravindran N, Galvao J, Kapoor N, Haamedi N, et al. Topical recombinant human Nerve growth factor (rh-NGF) is neuroprotective to retinal ganglion cells by targeting secondary degeneration. Sci Rep. 2020;10:3375. https://doi.org/10.1038/s41598-020-60427-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sacchetti M, Komaiha C, Bruscolini A, Albanese GM, Marenco M, Colabelli Gisoldi R, et al. Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation. Graefes Arch Clin Exp Ophthalmol. 2022;260:917–25. https://doi.org/10.1007/s00417-021-05431-6.

Article  CAS  PubMed  Google Scholar