Cost-effectiveness analysis of initial treatment with single-pill combination antihypertensive medications

Muntner P, Hardy ST, Fine LJ, Jaeger BC, Wozniak G, Levitan EB, et al. Trends in blood pressure control among US adults with hypertension, 1999-2000 to 2017-2018. JAMA. 2020;324:1190–1200. https://doi.org/10.1001/jama.2020.14545.

Article  PubMed  Google Scholar 

U.S. Department of Health and Human Services. The Surgeon General’s Call to Action to Control Hypertension. Washington, DC: U.S. Department of Health and Human Services, Office of the Surgeon General; 2020.

Parati G, Kjeldsen S, Coca A, Cushman WC, Wang J. Adherence to single-pill versus free-equivalent combination therapy in hypertension: a systematic review and meta-analysis. Hypertension. 2021;77:692–705. https://doi.org/10.1161/HYPERTENSIONAHA.120.15781.

Article  CAS  PubMed  Google Scholar 

Chow CK, Atkins ER, Hillis GS, Nelson MR, Reid CM, Schlaich MP, et al. Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial. Lancet. 2021;398:1043–52. https://doi.org/10.1016/S0140-6736(21)01922-X.

Article  PubMed  Google Scholar 

Law MR, Wald NJ, Morris JK, Jordan RE. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ. 2003;326:1427–0. https://doi.org/10.1136/bmj.326.7404.1427.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122:290–300. https://doi.org/10.1016/j.amjmed.2008.09.038.

Article  PubMed  Google Scholar 

Derington CG, King JB, Herrick JS, Shimbo D, Kronish IM, Saseen JJ, et al. Trends in antihypertensive medication monotherapy and combination use among US adults, National Health and Nutrition Examination Survey 2005–2016. Hypertension. 2020;75:973–81. https://doi.org/10.1161/HYPERTENSIONAHA.119.14360.

Article  CAS  PubMed  Google Scholar 

Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71:e13–e115. https://doi.org/10.1161/HYP.0000000000000065.

Article  CAS  PubMed  Google Scholar 

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J. 2018;39:3021–104. https://doi.org/10.1093/eurheartj/ehy339.

Article  PubMed  Google Scholar 

Derington CG, Cohen JB, Bress AP. Restoring the upward trend in blood pressure control rates in the United States: a focus on fixed-dose combinations. J Hum Hypertens. 2020;34:617–23. https://doi.org/10.1038/s41371-020-0340-6.

Article  PubMed  PubMed Central  Google Scholar 

Rabbani A, Alexander GC. Out-of-pocket and total costs of fixed-dose combination antihypertensives and their components. Am J Hypertens. 2008;21:509–13.

Article  PubMed  Google Scholar 

Fontil V, Bibbins-Domingo K, Kazi DS, Sidney S, Coxson PG, Khanna R, et al. Simulating strategies for improving control of hypertension among patients with usual source of care in the United States: The Blood Pressure Control Model. J Gen Intern Med. 2015;30:1147–55. https://doi.org/10.1007/s11606-015-3231-8.

Article  PubMed  PubMed Central  Google Scholar 

Bryant KB, Moran AE, Kazi DS, Zhang Y, Penko J, Ruiz-Negrón N, et al. Cost-effectiveness of hypertension treatment by pharmacists in Black barbershops. Circulation. 2021;143:2384–94. https://doi.org/10.1161/CIRCULATIONAHA.120.051683.

Article  PubMed  PubMed Central  Google Scholar 

Bellows BK, Ruiz-Negrón N, Bibbins-Domingo K, King JB, Pletcher MJ, Moran AE, et al. Clinic-based strategies to reach United States Million Hearts 2022 blood pressure control goals. Circ Cardiovasc Qual Outcomes. 2019;12:e005624 https://doi.org/10.1161/CIRCOUTCOMES.118.005624.

Article  PubMed  PubMed Central  Google Scholar 

Kohli-Lynch CN, Bellows BK, Thanassoulis G, Zhang Y, Pletcher MJ, Vittinghoff E, et al. Cost-effectiveness of low-density lipoprotein cholesterol level–guided statin treatment in patients with borderline cardiovascular risk. JAMA Cardiol. 2019;4:969 https://doi.org/10.1001/jamacardio.2019.2851.

Article  PubMed  PubMed Central  Google Scholar 

Kohli-Lynch CN, Bellows BK, Zhang Y, Spring B, Kazi DS, Pletcher MJ, et al. Cost-effectiveness of lipid-lowering treatments in young adults. J Am Coll Cardiol. 2021;78:1954–64. https://doi.org/10.1016/j.jacc.2021.08.065.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeki Al Hazzouri A, Vittinghoff E, Zhang Y, Pletcher MJ, Moran AE, Bibbins-Domingo K, et al. Use of a pooled cohort to impute cardiovascular disease risk factors across the adult life course. Int J Epidemiol. 2019;48:1004–13. https://doi.org/10.1093/ije/dyy264.

Article  PubMed  Google Scholar 

Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, et al. Harmonization of respiratory data from 9 US population-based cohorts: the NHLBI Pooled Cohorts Study. Am J Epidemiol. 2018;187:2265–78. https://doi.org/10.1093/aje/kwy139.

Article  PubMed  PubMed Central  Google Scholar 

Law M, Wald N, Morris J. Lowering blood pressure to prevent myocardial infarction and stroke: a new preventive strategy. Health Technol Assess. 2003;7:1–94. https://doi.org/10.3310/hta7310.

Article  CAS  PubMed  Google Scholar 

Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665 https://doi.org/10.1136/bmj.b1665.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lowy A, Munk VC, Ong SH, Burnier M, Vrijens B, Tousset EP, et al. Effects on blood pressure and cardiovascular risk of variations in patients’ adherence to prescribed antihypertensive drugs: role of duration of drug action. Int J Clin Pr. 2011;65:41–53. https://doi.org/10.1111/j.1742-1241.2010.02569.x.

Article  CAS  Google Scholar 

Bryant KB, Sheppard JP, Ruiz-Negrón N, Kronish IM, Fontil V, King JB, et al. Impact of self-monitoring of blood pressure on processes of hypertension care and long-term blood pressure control. J Am Heart Assoc. 2020;9:e016174 https://doi.org/10.1161/JAHA.120.016174.

Article  PubMed  PubMed Central  Google Scholar 

Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001;23:1296–310. https://doi.org/10.1016/s0149-2918(01)80109-0.

Article  CAS  PubMed  Google Scholar 

Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008;336:1114–7. https://doi.org/10.1136/bmj.39553.670231.25.

Article  PubMed  PubMed Central  Google Scholar 

Levy J, Rosenberg M, Vanness D. A Transparent and consistent approach to assess US outpatient drug costs for use in cost-effectiveness analyses. Value Health. 2018;21:677–84. https://doi.org/10.1016/j.jval.2017.06.013.

Article  PubMed  Google Scholar 

Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387:957–67. https://doi.org/10.1016/S0140-6736(15)01225-8.

Article  PubMed  Google Scholar 

Price Indexes for Personal Consumption Expenditures by Type of Product. Bureau of Economic Analysis, U.S. Department of Commerce, 2019. Accessed August 12, 2021. https://apps.bea.gov/iTable/iTable.cfm?reqid=19&step=2#reqid=19&step=2&isuri=1&1921=underlying.

Anderson JL, Heidenreich PA, Barnett PG, Creager MA, Fonarow GC, Gibbons RJ, et al. ACC/AHA statement on cost/value methodology in clinical practice guidelines and performance measures: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2304–22. https://doi.org/10.1016/j.jacc.2014.03.016.

Article  PubMed  Google Scholar 

Salam A, Kanukula R, Atkins E, Wang X, Islam S, Kishore SP, et al. Efficacy and safety of dual combination therapy of blood pressure-lowering drugs as initial treatment for hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2019;37:1768–74. https://doi.org/10.1097/HJH.0000000000002096.

Article  CAS  PubMed  Google Scholar 

Husereau D, Drummond M, Augustovski F, de Bekker-Grob E, Briggs AH, Carswell C, et al. Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations. Value Health. 2022;25:3–9. https://doi.org/10.1016/j.jval.2021.11.1351.

Article  PubMed  Google Scholar 

Wang X, Chen H, Essien E, Wu J, Serna O, Paranjpe R, et al. Cost-effectiveness analysis of antihypertensive triple combination therapy among patients enrolled in a Medicare advantage plan. Expert Rev Pharmacoecon Outcomes Res. 2021;21:829–836. https://doi.org/10.1080/14737167.2020.1800457.

Article  CAS  PubMed  Google Scholar 

Lin JK, Moran AE, Bibbins-Domingo K, Falase B, Pedroza Tobias A, Mandke CN, et al. Cost-effectiveness of a fixed-dose combination pill for secondary prevention of cardiovascular disease in China, India, Mexico, Nigeria, and South Africa: a modelling study. Lancet Glob Health. 2019;7:e1346–e1358. https://doi.org/10.1016/S2214-109X(19)30339-0.

Article  PubMed  Google Scholar 

Stafylas P, Kourlaba G, Hatzikou M, Georgiopoulos D, Sarafidis P, Maniadakis N. Economic evaluation of a single-pill triple antihypertensive therapy with valsartan, amlodipine, and hydrochlorothiazide against its dual components. Cost Eff Resour Alloc. 2015;13:10 https://doi.org/10.1186/s12962-015-0036-x.

Article  PubMed  PubMed Central  Google Scholar 

Glasziou PP, Clarke P, Alexander J, Rajmokan M, Beller E, Woodward M, et al. Cost-effectiveness of lowering blood pressure with a fixed combination of perindopril and indapamide in type 2 diabetes mellitus: an ADVANCE trial-based analysis. Med J Aust. 2010;193:320–4. https://doi.org/10.5694/j.1326-5377.2010.tb03941.x.

Article  PubMed  Google Scholar 

Lung T, Jan S, Asita de Silva H, Guggilla R, Maulik PK, Naik N, et al. Fixed-combination, low-dose, triple-pill antihypertensive medication versus usual care in patients with mild-to-moderate hypertension in Sri Lanka: a within-trial and modelled economic evaluation of the TRIUMPH trial. Lancet Glob Health. 2019;7:e1359–e1366. https://doi.org/10.1016/S2214-109X(19)30343-2.

留言 (0)

沒有登入
gif