Effect of vitamins C and E on cancer survival; a systematic review

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

PubMed  Article  Google Scholar 

Abiri B, Vafa M, Vitamin C, Cancer. The role of vitamin C in disease progression and quality of life in cancer patients. Nutr Cancer. 2021;73:1282–92.

CAS  PubMed  Article  Google Scholar 

Morrin HR, Pullar JM, Spencer E, Vissers MCM, Robinson BA, Dachs GU. Low vitamin C status in patients with cancer is associated with patient and tumor characteristics. Nutrients. 2020;12:2338. https://doi.org/10.3390/nu12082338.

CAS  Article  PubMed Central  Google Scholar 

Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005;102:13604–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, et al. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A. 2007;104:8749–54.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fu J, Wu Z, Liu J, Wu T, Vitamin C. A stem cell promoter in cancer metastasis and immunotherapy. Biomed Pharmacother. 2020;131:110588. https://doi.org/10.1016/j.biopha.2020.110588.

CAS  Article  PubMed  Google Scholar 

Mehdi WA, Zainulabdeen JA, Mehde AA. Investigation of the antioxidant status in multiple myeloma patients: effects of therapy. Asian Pac J Cancer Prev. 2013;14:3663–7.

PubMed  Article  Google Scholar 

Vollbracht C, Schneider B, Leendert V, Weiss G, Auerbach L, Beuth J. Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In Vivo. 2011;25:983–90.

CAS  PubMed  Google Scholar 

Codini M. Why Vitamin C could be an excellent complementary remedy to conventional therapies for breast cancer. Int J Mol Sci. 2020;21:8397. https://doi.org/10.3390/ijms21218397.

CAS  Article  PubMed Central  Google Scholar 

Li P, Han B, Jia H, Mo S, Deng K, Huang Y, et al. High-dose vitamin C tends to kill colorectal cancer with high MALAT1 expression. J Oncol. 2020; 2020:2621308. https://doi.org/10.1155/2020/2621308.

Zhang D, Xu P, Li Y, Wei B, Yang S, Zheng Y, et al. Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies. Aging. 2020;12:18415–35.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Roa FJ, Peña E, Gatica M, Escobar-Acuña K, Saavedra P, Maldonado M, et al. Therapeutic use of vitamin C in cancer: physiological considerations. Front Pharmacol. 2020;11:211. https://doi.org/10.3389/fphar.2020.00211.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Zasowska-Nowak A, Nowak PJ, Ciałkowska-Rysz A. High-dose vitamin C in advanced-stage cancer patients. Nutrients. 2021;13:735. https://doi.org/10.3390/nu13030735.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Moore C, Palau VE, Mahboob R, Lightner J, Stone W, Krishnan K. Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells. BMC Cancer. 2020;20:428. https://doi.org/10.1186/s12885-020-06947-6.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Figueroa Gonzalez D, Young F. Gamma tocopherol reduced chemotherapeutic-induced ROS in an ovarian granulosa cell line, but not in breast cancer cell lines in vitro. Antioxid (Basel). 2020;9:51. https://doi.org/10.3390/antiox9010051.

CAS  Article  Google Scholar 

Wei CW, Yu YL, Chen YH, Hung YT, Yiang GT. Anticancer effects of methotrexate in combination with α–tocopherol and α–tocopherol succinate on triple–negative breast cancer. Oncol Rep. 2019;41:2060–6.

CAS  PubMed  Google Scholar 

Ding Y, Fan J, Fan Z, Zhang K. γ-Tocotrienol reverses multidrug resistance of breast cancer cells through the regulation of the γ-Tocotrienol-NF-κB-P-gp axis. J Steroid Biochem Mol Biol. 2021;209:105835. https://doi.org/10.1016/j.jsbmb.2021.105835.

CAS  Article  PubMed  Google Scholar 

Peh HY, Tan WS, Liao W, Wong WS. Vitamin E therapy beyond cancer: tocopherol versus tocotrienol. Pharmacol Ther. 2016;162:152–69.

CAS  PubMed  Article  Google Scholar 

Harris HR, Orsini N, Wolk A. Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cancer. 2014;50:1223–31.

CAS  PubMed  Article  Google Scholar 

Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Int J Food Sci Nutr. 2016;67:744–53.

CAS  PubMed  Article  Google Scholar 

Fritz H, Flower G, Weeks L, Cooley K, Callachan M, McGowan J, et al. Intravenous vitamin C and cancer: a systematic review. Integr Cancer Ther. 2014;13:280–300.

CAS  PubMed  Article  Google Scholar 

Nauman G, Gray JC, Parkinson R, Levine M, Paller CJ. Systematic review of intravenous ascorbate in cancer clinical trials. Antioxid (Basel). 2018;7:89. https://doi.org/10.3390/antiox7070089.

CAS  Article  Google Scholar 

van Gorkom GNY, Lookermans EL, Van Elssen CHMJ, Bos GMJ. The Effect of Vitamin C (Ascorbic Acid) in the treatment of patients with cancer: a systematic review. Nutrients. 2019;11:977. https://doi.org/10.3390/nu11050977.

CAS  Article  PubMed Central  Google Scholar 

Jacobs C, Hutton B, Ng T, Shorr R, Clemons M. Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? a systematic review. Oncologist. 2015;20:210–23.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Alkhenizan A, Hafez K. The role of vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials. Ann Saudi Med. 2007;27:409–14.

PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71.

Article  PubMed  PubMed Central  Google Scholar 

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1–12. https://doi.org/10.1016/0197-2456(95)00134-4.

CAS  Article  PubMed  Google Scholar 

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Cochrane Bias Methods Group; Cochrane Statistical Methods Group. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. https://doi.org/10.1136/bmj.d5928.

Article  PubMed  PubMed Central  Google Scholar 

Ou J, Zhu X, Chen P, Du Y, Lu Y, Peng X, et al. A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer. J Adv Res. 2020;24:175–82. https://doi.org/10.1016/j.jare.2020.03.004.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Allen BG, Bodeker KL, Smith MC, Monga V, Sandhu S, Hohl R, et al. First-in-human phase i clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clin Cancer Res. 2019;25:6590–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mikirova N, Casciari J, Hunninghake R. Continuous intravenous vitamin C in the cancer treatment: re-evaluation of a Phase I clinical study. FFHD. 2019;9:180–204.

CAS  Article  Google Scholar 

Wang F, He MM, Wang ZX, Li S, Jin Y, Ren C, et al. Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer. BMC Cancer. 2019;19:460. https://doi.org/10.1186/s12885-019-5696-z.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Zhao H, Zhu H, Huang J, Zhu Y, Hong M, Zhu H, et al. The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia. Leuk Res. 2018;66:1–7.

CAS  PubMed  Article  Google Scholar 

Nielsen TK, Højgaard M, Andersen JT, Jørgensen NR, Zerahn B, Kristensen B, et al. Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial. Transl Androl Urol. 2017;6:517–28.

PubMed  PubMed Central  Article  Google Scholar 

Polireddy K, Dong R, Reed G, Yu J, Chen P, Williamson S, et al. High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis: mechanisms and a phase I/IIa study. Sci Rep. 2017;7:17188. https://doi.org/10.1038/s41598-017-17568-8.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, et al. O2⋅- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell. 2017;31:487-500.e8.

CAS  PubMed  PubMed Central  Article 

留言 (0)

沒有登入
gif