Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
Abiri B, Vafa M, Vitamin C, Cancer. The role of vitamin C in disease progression and quality of life in cancer patients. Nutr Cancer. 2021;73:1282–92.
CAS PubMed Article Google Scholar
Morrin HR, Pullar JM, Spencer E, Vissers MCM, Robinson BA, Dachs GU. Low vitamin C status in patients with cancer is associated with patient and tumor characteristics. Nutrients. 2020;12:2338. https://doi.org/10.3390/nu12082338.
CAS Article PubMed Central Google Scholar
Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005;102:13604–9.
CAS PubMed PubMed Central Article Google Scholar
Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, et al. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A. 2007;104:8749–54.
CAS PubMed PubMed Central Article Google Scholar
Fu J, Wu Z, Liu J, Wu T, Vitamin C. A stem cell promoter in cancer metastasis and immunotherapy. Biomed Pharmacother. 2020;131:110588. https://doi.org/10.1016/j.biopha.2020.110588.
CAS Article PubMed Google Scholar
Mehdi WA, Zainulabdeen JA, Mehde AA. Investigation of the antioxidant status in multiple myeloma patients: effects of therapy. Asian Pac J Cancer Prev. 2013;14:3663–7.
Vollbracht C, Schneider B, Leendert V, Weiss G, Auerbach L, Beuth J. Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In Vivo. 2011;25:983–90.
Codini M. Why Vitamin C could be an excellent complementary remedy to conventional therapies for breast cancer. Int J Mol Sci. 2020;21:8397. https://doi.org/10.3390/ijms21218397.
CAS Article PubMed Central Google Scholar
Li P, Han B, Jia H, Mo S, Deng K, Huang Y, et al. High-dose vitamin C tends to kill colorectal cancer with high MALAT1 expression. J Oncol. 2020; 2020:2621308. https://doi.org/10.1155/2020/2621308.
Zhang D, Xu P, Li Y, Wei B, Yang S, Zheng Y, et al. Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies. Aging. 2020;12:18415–35.
CAS PubMed PubMed Central Article Google Scholar
Roa FJ, Peña E, Gatica M, Escobar-Acuña K, Saavedra P, Maldonado M, et al. Therapeutic use of vitamin C in cancer: physiological considerations. Front Pharmacol. 2020;11:211. https://doi.org/10.3389/fphar.2020.00211.
CAS Article PubMed PubMed Central Google Scholar
Zasowska-Nowak A, Nowak PJ, Ciałkowska-Rysz A. High-dose vitamin C in advanced-stage cancer patients. Nutrients. 2021;13:735. https://doi.org/10.3390/nu13030735.
CAS Article PubMed PubMed Central Google Scholar
Moore C, Palau VE, Mahboob R, Lightner J, Stone W, Krishnan K. Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells. BMC Cancer. 2020;20:428. https://doi.org/10.1186/s12885-020-06947-6.
CAS Article PubMed PubMed Central Google Scholar
Figueroa Gonzalez D, Young F. Gamma tocopherol reduced chemotherapeutic-induced ROS in an ovarian granulosa cell line, but not in breast cancer cell lines in vitro. Antioxid (Basel). 2020;9:51. https://doi.org/10.3390/antiox9010051.
Wei CW, Yu YL, Chen YH, Hung YT, Yiang GT. Anticancer effects of methotrexate in combination with α–tocopherol and α–tocopherol succinate on triple–negative breast cancer. Oncol Rep. 2019;41:2060–6.
Ding Y, Fan J, Fan Z, Zhang K. γ-Tocotrienol reverses multidrug resistance of breast cancer cells through the regulation of the γ-Tocotrienol-NF-κB-P-gp axis. J Steroid Biochem Mol Biol. 2021;209:105835. https://doi.org/10.1016/j.jsbmb.2021.105835.
CAS Article PubMed Google Scholar
Peh HY, Tan WS, Liao W, Wong WS. Vitamin E therapy beyond cancer: tocopherol versus tocotrienol. Pharmacol Ther. 2016;162:152–69.
CAS PubMed Article Google Scholar
Harris HR, Orsini N, Wolk A. Vitamin C and survival among women with breast cancer: a meta-analysis. Eur J Cancer. 2014;50:1223–31.
CAS PubMed Article Google Scholar
Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Int J Food Sci Nutr. 2016;67:744–53.
CAS PubMed Article Google Scholar
Fritz H, Flower G, Weeks L, Cooley K, Callachan M, McGowan J, et al. Intravenous vitamin C and cancer: a systematic review. Integr Cancer Ther. 2014;13:280–300.
CAS PubMed Article Google Scholar
Nauman G, Gray JC, Parkinson R, Levine M, Paller CJ. Systematic review of intravenous ascorbate in cancer clinical trials. Antioxid (Basel). 2018;7:89. https://doi.org/10.3390/antiox7070089.
van Gorkom GNY, Lookermans EL, Van Elssen CHMJ, Bos GMJ. The Effect of Vitamin C (Ascorbic Acid) in the treatment of patients with cancer: a systematic review. Nutrients. 2019;11:977. https://doi.org/10.3390/nu11050977.
CAS Article PubMed Central Google Scholar
Jacobs C, Hutton B, Ng T, Shorr R, Clemons M. Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? a systematic review. Oncologist. 2015;20:210–23.
CAS PubMed PubMed Central Article Google Scholar
Alkhenizan A, Hafez K. The role of vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials. Ann Saudi Med. 2007;27:409–14.
PubMed PubMed Central Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71.
Article PubMed PubMed Central Google Scholar
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1–12. https://doi.org/10.1016/0197-2456(95)00134-4.
CAS Article PubMed Google Scholar
Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Cochrane Bias Methods Group; Cochrane Statistical Methods Group. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. https://doi.org/10.1136/bmj.d5928.
Article PubMed PubMed Central Google Scholar
Ou J, Zhu X, Chen P, Du Y, Lu Y, Peng X, et al. A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer. J Adv Res. 2020;24:175–82. https://doi.org/10.1016/j.jare.2020.03.004.
CAS Article PubMed PubMed Central Google Scholar
Allen BG, Bodeker KL, Smith MC, Monga V, Sandhu S, Hohl R, et al. First-in-human phase i clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clin Cancer Res. 2019;25:6590–7.
CAS PubMed PubMed Central Article Google Scholar
Mikirova N, Casciari J, Hunninghake R. Continuous intravenous vitamin C in the cancer treatment: re-evaluation of a Phase I clinical study. FFHD. 2019;9:180–204.
Wang F, He MM, Wang ZX, Li S, Jin Y, Ren C, et al. Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer. BMC Cancer. 2019;19:460. https://doi.org/10.1186/s12885-019-5696-z.
CAS Article PubMed PubMed Central Google Scholar
Zhao H, Zhu H, Huang J, Zhu Y, Hong M, Zhu H, et al. The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia. Leuk Res. 2018;66:1–7.
CAS PubMed Article Google Scholar
Nielsen TK, Højgaard M, Andersen JT, Jørgensen NR, Zerahn B, Kristensen B, et al. Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial. Transl Androl Urol. 2017;6:517–28.
PubMed PubMed Central Article Google Scholar
Polireddy K, Dong R, Reed G, Yu J, Chen P, Williamson S, et al. High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis: mechanisms and a phase I/IIa study. Sci Rep. 2017;7:17188. https://doi.org/10.1038/s41598-017-17568-8.
CAS Article PubMed PubMed Central Google Scholar
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, et al. O2⋅- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell. 2017;31:487-500.e8.
留言 (0)