Wen J, Peng H, Wang D, Wen Z, Liu Y, Qu J, et al. Lipopolysaccharides protect mesenchymal stem cell against cardiac ischemia-reperfusion injury by HMGB1/STAT3 signaling. J Geriatr Cardiol. 2023;20:801–12.

Luo X, Zhang C, Yue C, Jiang Y, Yang F, Xian YJCs. A near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia-reperfusion injury. Chem Sci. 2023;14:14290–301.

Shi P, Wu J, Li M, Cao Y, Wu J, Ren P, et al. Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function. Cell Death Discov. 2023;9:466.

Jin J, Xu F, Zhang Y, Guan J, Fu J. Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor. Mol Immunol. 2023;155:27–43.

Article  CAS  PubMed  Google Scholar 

Chen M, Zhong G, Liu M, He H, Zhou J, Chen J, et al. Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia/reperfusion injury. Pharmacol Res. 2023;189:106682.

Article  CAS  PubMed  Google Scholar 

Liao CL, Liu Y, Huang MZ, Liu HY, Ye ZL, Su Q. Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function. Stem Cell Res Ther. 2021;12:89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang P, Yu Y, Wang P, Shen H, Ling X, Xue X, et al. Role of hydrogen sulfide in myocardial ischemia-reperfusion injury. J Cardiovasc Pharmacol. 2021;77:130–41.

Article  CAS  PubMed  Google Scholar 

Tang C, Hu Y, Gao J, Jiang J, Shi S, Wang J, et al. Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat. Life Sci. 2020;257:118004.

Article  CAS  PubMed  Google Scholar 

Yu W, Lyu J, Jia L, Sheng M, Yu H, Du H. Dexmedetomidine ameliorates hippocampus injury and cognitive dysfunction induced by hepatic ischemia/reperfusion by activating SIRT3-mediated mitophagy and inhibiting activation of the NLRP3 inflammasome in young rats. Oxid Med Cell Longev. 2020;2020:7385458.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Zhang X, Chen M, Chen J, Gao T, Yao S. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades. EXCLI J. 2018;17:302–11.

PubMed  PubMed Central  Google Scholar 

Liang S, Wang Y, Liu Y. Dexmedetomidine alleviates lung ischemia-reperfusion injury in rats by activating PI3K/Akt pathway. Eur Rev Med Pharmacol Sci. 2019;23:370–7.

CAS  PubMed  Google Scholar 

Yang J, Wu Y, Xu Y, Jia J, Xi W, Deng H, et al. Dexmedetomidine resists intestinal ischemia-reperfusion injury by inhibiting TLR4/MyD88/NF-kappaB signaling. J Surg Res. 2021;260:350–8.

Article  CAS  PubMed  Google Scholar 

Yu P, Zhang J, Ding Y, Chen D, Sun H, Yuan F, et al. Dexmedetomidine post-conditioning alleviates myocardial ischemia-reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation. Hum Cell. 2022;35:836–48.

Article  CAS  PubMed  Google Scholar 

Wang Z, Yao M, Jiang L, Wang L, Yang Y, Wang Q, et al. Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3beta/Nrf2 axis. Biomed Pharmacother. 2022;154:113572.

Article  CAS  PubMed  Google Scholar 

He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, et al. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nat Commun. 2021;12:4371.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, et al. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021;49:4203–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Chen S, Zhang B, Liu J. SIRT3 as a potential therapeutic target for heart failure. Pharmacol Res. 2021;165:105432.

Article  CAS  PubMed  Google Scholar 

Sun W, Liu C, Chen Q, Liu N, Yan Y, Liu B. SIRT3: A new regulator of cardiovascular diseases. Oxid Med Cell Longev. 2018;2018:7293861.

Article  PubMed  PubMed Central  Google Scholar 

Fu Z, Pang Z, He L, Zhang L, Fan Y, Zhao C, et al. Dexmedetomidine confers protection against neuronal oxygen glucose deprivation-reperfusion by regulating SIRT3 mediated autophagy. Neurochem Res. 2022;47:3490–505.

Article  CAS  PubMed  Google Scholar 

Zhang Q, Liu XM, Hu Q, Liu ZR, Liu ZY, Zhang HG, et al. Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway. J Transl Med. 2021;19:463.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao WH, Shan XS, Zhang JX, Liu HY, Wang BY, Wei X, et al. Dexmedetomidine attenuates ferroptosis-mediated renal ischemia/reperfusion injury and inflammation by inhibiting ACSL4 via alpha2-AR. Front Pharmacol. 2022;13:782466.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Wang Z, Xie X, Luo M, Shen H, Li X, et al. Peroxiredoxin-3 plays a neuroprotective role in early brain injury after experimental subarachnoid hemorrhage in rats. Brain Res Bull. 2022;193:95–105.

Article  PubMed  Google Scholar 

Sonn SK, Song EJ, Seo S, Kim YY, Um JH, Yeo FJ, et al. Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control. Redox Biol. 2022;51:102275.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, He P, Wang XL, Zhang S, Devejian N, Bennett E, et al. Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway. Free Radic Biol Med. 2018;123:8–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Jiao L, Shao Y, Li H, Sun L, Yu Q, et al. LncRNA-ZFAS1 promotes myocardial ischemia-reperfusion injury through DNA methylation-mediated Notch1 Down-regulation in mice. JACC Basic Transl Sci. 2022;7:880–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu Z, He Y, Ming H, Lei S, Leng Y, Xia ZY. Lipopolysaccharide (LPS) aggravates high glucose- and hypoxia/reoxygenation-induced injury through activating ROS-dependent NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019;2019:8151836.

Article  PubMed  PubMed Central  Google Scholar 

Xu H, Ba Z, Liu C, Yu XJTo. Long noncoding RNA DLEU1 promotes proliferation and glycolysis of gastric cancer cells via APOC1 upregulation by recruiting SMYD2 to induce trimethylation of H3K4 modification. Transl Oncol. 2023;36:101731.

Wang Z, Sun R, Wang G, Chen Z, Li Y, Zhao Y, et al. SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury. Redox Biol. 2020;28:101343.

Article  CAS  PubMed  Google Scholar 

Liang C, Peng Y, Sun H, Wang L, Jiang L, Zou S. Silencing lncRNA KCNQ1OT1 reduced hepatic ischemia reperfusion injury-induced pyroptosis by regulating miR-142a-3p/HMGB1 axis. Mol Cell Biochem. 2022;478:1293–305.

Wu T, Shi G, Ji Z, Wang S, Geng L, Guo Z. Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass. Cell Mol Biol Lett. 2022;27:95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cong D, Yu Y, Meng Y, Qi X. Dexmedetomidine (Dex) exerts protective effects on rat neuronal cells injured by cerebral ischemia/reperfusion via regulating the Sphk1/S1P signaling pathway. J Stroke Cerebrovasc Dis. 2023;32:106896.

Article  PubMed  Google Scholar 

Shan X, Zhang J, Wei X, Tao W, Peng K, Liu H, et al. Dexmedetomidine attenuates renal ischemia-reperfusion injury through activating PI3K/Akt-eNOS signaling via alpha(2) adrenoreceptors in renal microvascular endothelial cells. FASEB J. 2022;36:e22608.

Article  CAS  PubMed  Google Scholar 

Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, et al. Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner. Redox Biol. 2022;54:102390.

Article  CAS  PubMed  PubMed Central  Google Scholar