Advances in Pharmacology and Pharmacy Vol. 10(3), pp. 199 - 208
DOI: 10.13189/app.2022.100306
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Sowjanya Hatthi Belgal Mundarinti 1, Hindustan Abdul Ahad 2,*
1 Department of Pharmaceutical Sciences, Research Scholar, Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu-515001, Andhra Pradesh, India
2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-515721, Andhra Pradesh, India

ABSTRACT

Aim: Searching for a new polymer that can be used in pharmaceutical formulation is a laborious and cost oriented practice. To resolve this, researchers are in search of a cost-effective and reliable excipient. Synthetic polymers are costly, whereas natural ones are abundant and economical. In the same way, discovering a new drug is a horrendous process with time, cost, and approval. The study's goal is to investigate Mastic gum's mucoadhesive properties by incorporating it into mucoadhesive microspheres with Amoxicillin trihydrate as a model drug. Methods: Nine interpretations of mucoadhesive microspheres were made with carbomer 934P and varying proportions of mastic gum (MG). A central composite design with design expert software is used to check the impact of independent variables (mastic gum and carbomer 934 P levels) on entrapment efficacy and mucoadhesion time as the responses. As part of congeniality studies, the microspheres were examined for amoxicillin trihydrate (ATH) content and liberation. Results: Good quality microspheres were formed that showed suitability with the excipients and possessed appreciable outcomes for the tests conducted. The study expressed the equation for ATH entrapment as +82.70+0.1333A+6.40B+0.0500AB+ 0.0000A2-2.80B2 and the mucoadhesion time as +13.10+0.2500A+1.42B-0.0500AB+0.1500A2+0.1500B2. These equations indicate the impact of independent variables on the response studies. These equations discovered that ATH entrapment increased with an increase in MG levels in the formulations and that the mucoadhesion time was greater in formulations with higher MG levels. In formulations containing higher levels of MG, the drug release is slightly reduced. Conclusion: The study summarized that amoxicillin trihydrate is capable of good stomach-specific drug delivery by carbomer 934P and enhanced by mastic gum when prepared as mucoadhesive microspheres that are cost-effective, operational, and stable. This approach also resolves the gastric retention of ATH to eradicate H. pylori and the mastic gum has proved an anti-ulcer possession.

KEYWORDS
Amoxicillin Trihydrate, Design, H. pylori, Mastic Gum, Microspheres, Mucoadhesive

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Sowjanya Hatthi Belgal Mundarinti , Hindustan Abdul Ahad , "Central Composite Design Screened Mastic Gum Abetted Mucoadhesive Microspheres of Amoxicillin Trihydrate for Exterminating H. pylori," Advances in Pharmacology and Pharmacy, Vol. 10, No. 3, pp. 199 - 208, 2022. DOI: 10.13189/app.2022.100306.

(b). APA Format:
Sowjanya Hatthi Belgal Mundarinti , Hindustan Abdul Ahad (2022). Central Composite Design Screened Mastic Gum Abetted Mucoadhesive Microspheres of Amoxicillin Trihydrate for Exterminating H. pylori. Advances in Pharmacology and Pharmacy, 10(3), 199 - 208. DOI: 10.13189/app.2022.100306.