Advances in Pharmacology and Pharmacy Vol. 12(2), pp. 116 - 124
DOI: 10.13189/app.2024.120204
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Idoko A 1,2,*, Firdous S M 3, Ufedo-Enyo G. Emmanuel 1, Sofia Khanam 3, Ike P O 4
1 Department of Biochemistry, Faculty of Natural Sciences, Caritas University, Nigeria
2 Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nigeria
3 Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, India
4 Department of Industrial Physics, David Umahi Federal University of Health Sciences, Nigeria

ABSTRACT

This study aimed to scrutinize the effect of the ethanol extracts of leaf and stem bark of Flacourtia indica (F. indica) on blood and liver in aluminum chloride (AlCl3) challenged Wistar rats. Twenty-four male Wistar rats, weighing 180-210 g were split into six groups (A-F) [n=6], and treated with AlCl3 (5 days) and extracts (1 week); viz., group A: normal control, group B: AlCl3 (260 mg/kg), group C: AlCl3 (260 mg/kg) + leaf extract of F. indica (500 mg/kg), group D: AlCl3 (260 mg/kg) + leaf extract of F. indica (500 mg/kg), group E: AlCl3 (260 mg/kg) + bark extract of F. indica (625 mg/kg), and group F: AlCl3 (260 mg/kg) + bark extract of F. indica (625 mg/kg). In the severe toxicity study, death was recorded at 3500mg/kg bark extract dose. Animals intoxicated with AlCl3 exhibited a significant rise in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood glucose, and bilirubin (BIL) concentrations; and a decrease in total protein (TP) and albumin (ALB) concentration. Also, a considerable decrease in packed cell volume (PCV) and hemoglobin; and histological artifacts were also remarked in animals intoxicated with AlCl3. Treatment with the leaf and bark extracts of F. indica exhibited a significant reversal of the above said artifacts. The extracts also improved the histological features of the liver. It may be concluded that treatment of the AlCl3 induced anemic and hepatic injured rats with leaf and stem bark F. indica, attenuated these conditions effectively, as evident in the reduced concentrations of liver marker enzymes, and improved the levels of PCV and hemoglobin.

KEYWORDS
Flacourtia indica, Aluminum Chloride, Aspartate Aminotransferase, Alkaline Phosphatase, Alanine Aminotransferase, Hemoglobin, Anemia

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Idoko A , Firdous S M , Ufedo-Enyo G. Emmanuel , Sofia Khanam , Ike P O , "Comparative Study of Hepatoprotective and Hematinic Activities of Ethanolic Extracts of Flacourtia indica's Leaf and Stem Bark," Advances in Pharmacology and Pharmacy, Vol. 12, No. 2, pp. 116 - 124, 2024. DOI: 10.13189/app.2024.120204.

(b). APA Format:
Idoko A , Firdous S M , Ufedo-Enyo G. Emmanuel , Sofia Khanam , Ike P O (2024). Comparative Study of Hepatoprotective and Hematinic Activities of Ethanolic Extracts of Flacourtia indica's Leaf and Stem Bark. Advances in Pharmacology and Pharmacy, 12(2), 116 - 124. DOI: 10.13189/app.2024.120204.