Advances in Pharmacology and Pharmacy Vol. 12(2), pp. 85 - 94
DOI: 10.13189/app.2024.120201
Reprint (PDF) (258Kb)

Rohit Jaysing Bhor *, Somnath Wadghane , Girish Kokate , Mahesh H Kolhe
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, India

ABSTRACT

Introduction: 5, 5-diphenylimidazolidine is a heterocyclic hydrocarbon with distinctive basic structural properties in its molecular structure. A novel series of (E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl)-5,5-diphenylimidazolidine-2,4-dione and its derivatives were created by treating different1-acetyl-5,5-diphenylimidazolidine-2,4-dione (0.025 mol) with an equimolar quantity of 4-methyl benzaldehyde. Methods: The structure of synthesised compounds was confirmed using FTIR, NMR spectroscopy, and MS. The agar dilution method was used to test the title compounds and their derivatives for in vitro antibacterial activities against various human pathogenic microorganisms. Ciprofloxacin was used as the standard medication. All of the title compounds were active against some strains of microorganism. According to structural activity connection research, compounds with an electron-withdrawing group have higher activity than compounds with electron-donating groups. Results: Based on the results obtained, when compared to common medicines like Ciprofloxacin; the compounds 4-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)-4-oxobutanoic acid (SW1)(E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl)-5,5-diphenylimidazolidine-2,4-dione (SW2)(E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl)-5,5-diphenylimidazolidine-2,4-dione (SW3) showed good significant activity. Conclusion: The antibacterial activity of the title compounds and their derivatives was examined. According to structural activity relationship studies, compounds containing 5, 5-diphenylimidazolidine derivatives with an electron-withdrawing group perform better than compounds with electron-donating groups. Table 3 shows the preliminary antimicrobial testing findings of the produced compounds, including the usual broad spectrum antibacterial medication Ciprofloxacin. The synthetic compounds have been evaluated for their capacity to inhibit (E)-1-(3-oxo-3-(p-tolyl)prop-1-en-1-yl) and their antibacterial activity. Derivatives of -5,5-diphenylimidazolidine-2,4-dione (SW2) have significant antibacterial action.

KEYWORDS
Antibacterial, 5, 5-Diphenylimidazolidine-2, 4-Dione, Ciprofloxacin, 4-Methyl Benzaldehyde

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Rohit Jaysing Bhor , Somnath Wadghane , Girish Kokate , Mahesh H Kolhe , "Synthesis and In-Vitro Anti Bacterial Activity of (E)-1-(3-oxo-3-(p-tolyl) prop-1-en-1-yl)-5,5-Diphenylimidazolidine-2,4-Dione and its Derivatives," Advances in Pharmacology and Pharmacy, Vol. 12, No. 2, pp. 85 - 94, 2024. DOI: 10.13189/app.2024.120201.

(b). APA Format:
Rohit Jaysing Bhor , Somnath Wadghane , Girish Kokate , Mahesh H Kolhe (2024). Synthesis and In-Vitro Anti Bacterial Activity of (E)-1-(3-oxo-3-(p-tolyl) prop-1-en-1-yl)-5,5-Diphenylimidazolidine-2,4-Dione and its Derivatives. Advances in Pharmacology and Pharmacy, 12(2), 85 - 94. DOI: 10.13189/app.2024.120201.