Lambert JC, Ramirez A, Grenier-Boley B, Bellenguez C. Step by step: towards a better understanding of the genetic architecture of Alzheimer’s disease. Mol Psychiatry. 2023;28:2716–27.

Article  PubMed  PubMed Central  Google Scholar 

Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease. PLoS one. 2010;5:e13950.

Article  PubMed  PubMed Central  Google Scholar 

Singleton A, Hardy J. Progress in the genetic analysis of Parkinson’s disease. Hum Mol Genet. 2019;28:R215–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardy J. Failures in protein clearance partly underlie late onset neurodegenerative diseases and link pathology to genetic risk. Front Neurosci. 2019;13:1304.

Article  PubMed  PubMed Central  Google Scholar 

Ji CH, Kwon YT. Crosstalk and interplay between the ubiquitin-proteasome system and autophagy. Mol Cell. 2017;40:441–9.

Article  CAS  Google Scholar 

Korolchuk VI, Menzies FM, Rubinsztein DC. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett. 2010;584:1393–8.

Article  CAS  PubMed  Google Scholar 

Michalska P, Leon R. When it comes to an end: oxidative stress crosstalk with protein aggregation and neuroinflammation induce neurodegeneration. Antioxidants. 2020;9:740.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Freer R, Sormanni P, Vecchi G, Ciryam P, Dobson CM, Vendruscolo M. A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease. Sci Adv. 2016;2:e1600947.

Article  PubMed  PubMed Central  Google Scholar 

Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet. 2006;38:24–6.

Article  CAS  PubMed  Google Scholar 

Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, et al. alpha-Synuclein locus triplication causes Parkinson’s disease. Science. 2003;302:841.

Article  CAS  PubMed  Google Scholar 

Wallon D, Boluda S, Rovelet-Lecrux A, Thierry M, Lagarde J, Miguel L, et al. Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers. Acta Neuropathol. 2021;142:259–78.

Article  CAS  PubMed  Google Scholar 

Farrer M, Maraganore DM, Lockhart P, Singleton A, Lesnick TG, de Andrade M, et al. alpha-Synuclein gene haplotypes are associated with Parkinson’s disease. Hum Mol Genet. 2001;10:1847–51.

Article  CAS  PubMed  Google Scholar 

Singleton A, Myers A, Hardy J. The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases. Hum Mol Genet. 2004;13:R123–6.

Article  CAS  PubMed  Google Scholar 

Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, et al. Increased in vivo amyloid-beta42 production, exchange, and loss in presenilin mutation carriers. Sci Transl Med. 2013;5:189ra77.

Article  PubMed  Google Scholar 

Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, et al. Decreased clearance of CNS beta-amyloid in Alzheimer’s disease. Science. 2010;330:1774.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan X, Wheatley EG, Villeda SA. Mechanisms of hippocampal aging and the potential for rejuvenation. Annu Rev Neurosci. 2017;40:251–72.

Article  CAS  PubMed  Google Scholar 

Streit WJ. Microglial senescence: does the brain’s immune system have an expiration date? Trends Neurosci. 2006;29:506–10.

Article  CAS  PubMed  Google Scholar 

Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, et al. Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease. Brain. 2021;144:2186–98.

Article  PubMed  PubMed Central  Google Scholar 

Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ. Tau and alpha-synuclein pathology in amygdala of parkinsonism-dementia complex patients of Guam. Am J Pathol. 2002;160:1725–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Attems J, Jellinger KA. The overlap between vascular disease and Alzheimer’s disease–lessons from pathology. BMC Med. 2014;12:206.

Article  PubMed  PubMed Central  Google Scholar 

Farfel JM, Capuano AW, Buchman AS, Schneider JA, Bennett DA. Association of Alzheimer’s disease and other neuropathologies with functional disability in persons with and without dementia. J Gerontol A Biol Sci Med Sci. 2024;79:glae118.

Article  CAS  PubMed  Google Scholar 

Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007;69:2197–204.

Article  PubMed  Google Scholar 

Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001;293:1487–91.

Article  CAS  PubMed  Google Scholar 

Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, et al. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer’s disease and Parkinson’s disease. Proc Natl Acad Sci USA. 2001;98:12245–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M. Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nat Neurosci. 1998;1:355–8.

Article  CAS  PubMed  Google Scholar 

Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014;128:755–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lantos PL, Luthert PJ, Hanger D, Anderton BH, Mullan M, Rossor M. Familial Alzheimer’s disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer’s disease have the same cytoskeletal pathology. Neurosci Lett. 1992;137:221–4.

Article  CAS  PubMed  Google Scholar 

Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, et al. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer’s disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol. 1998;153:1365–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron. 2004;44:601–7.

Article  CAS  PubMed  Google Scholar 

Abramzon YA, Fratta P, Traynor BJ, Chia R. The overlapping genetics of amyotrophic lateral sclerosis and frontotemporal dementia. Front Neurosci. 2020;14:42.

Article  PubMed  PubMed Central