HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop

Ajalyakeen H, Almohareb M, Al-Assaf M. Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma. Dent Med Probl. 2020;57(3):227–31.

Article  PubMed  Google Scholar 

Alves A, Diel L, Ramos G, Pinto A, Bernardi L, Yates J, III, et al. Tumor microenvironment and oral squamous cell carcinoma: a crosstalk between the inflammatory state and tumor cell migration. Oral Oncol. 2021;112:105038.

Beider K, Voevoda-Dimenshtein V, Zoabi A, Rosenberg E, Magen H, Ostrovsky O, et al. CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression. J Hematol Oncol. 2022;15(1):144.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bi JG, Li Q, Guo YS, Liu LP, Bao SY, Xu P. Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis. Curr Med Sci. 2024;44(3):503–11.

Article  PubMed  CAS  Google Scholar 

Cao W, Qin K, Li F, Chen WQ. Comparative study of cancer profiles between 2020 and 2022 using global cancer statistics (GLOBOCAN). J Natl Cancer Ctr. 2024;4(2):128–34.

Article  Google Scholar 

Chen S, Lu K, Hou Y, You Z, Shu C, Wei X, et al. YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6. J Immunother of cancer. 2023;11(4):e006020.

Chen SW, Yang MW, Wang CY, Ouyang Y, Chen XF, Bai JW, et al. Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma (vol 503, pg 43, 2021). Cancer Lett. 2022;537:215688.

Chen X, Ma C, Li Y, Liang Y, Chen T, Han D, et al. COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk. Oncogene. 2024;43(23):1742–56.

Article  PubMed  CAS  Google Scholar 

Choi SK, Kim M, Lee H, Kwon Y, Cha HJ, Jang SJ, et al. Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutations. Cell Oncol (Dordrecht, Netherlands). 2022;45(5):913–30.

CAS  Google Scholar 

Dai Y, Ji Z, Liang H, Jiang M, Wang L, Bao X, et al. CD44v5 domain regulates crosstalk between TNBC cells and tumor-associated macrophages by enhancing the IL-4R/STAT3 axis. Cancer Sci. 2024;115(7):2235–53.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dorna D, Paluszczak J. Targeting cancer stem cells as a strategy for reducing chemotherapy resistance in head and neck cancers. J Cancer Res Clin Oncol. 2023;149(14):13417–35.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ernst BP, Wiesmann N, Gieringer R, Eckrich J, Brieger J. HSP27 regulates viability and migration of cancer cell lines following irradiation. J Proteomics. 2020;226:103886.

Article  PubMed  CAS  Google Scholar 

Feng H, Dong Y, Chen K, You Z, Weng J, Liang P, et al. Sphingomyelin synthase 2 promotes the stemness of breast cancer cells via modulating NF-kappaB signaling pathway. J Cancer Res Clin Oncol. 2024;150(2):46.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ghorbanpour M, Salarvand S, Salarvand S, Shahsavari F, Shirkhoda M, Shakib PA, et al. Depth of invasion and extranodal extension: the influential factors to predict survival rate of patients with oral tongue squamous cell carcinoma. Bmc Cancer. 2024;24(1):1256.

Article  PubMed  PubMed Central  Google Scholar 

Guo X, Zhang H, He C, Qin K, Lai Q, Fang Y, et al. RUNX1 promotes angiogenesis in colorectal cancer by regulating the crosstalk between tumor cells and tumor associated macrophages. Biomarker Res. 2024;12(1):29.

He Z, Wang J, Zhu C, Xu J, Chen P, Jiang X, et al. Exosome-derived FGD5-AS1 promotes tumor-associated macrophage M2 polarization-mediated pancreatic cancer cell proliferation and metastasis. Cancer Lett. 2022;548:215751.

Article  PubMed  CAS  Google Scholar 

Heiserman JP, Minhas Z, Nikpayam E, Cheon DJ. Targeting heat shock protein 27 and fatty acid oxidation augments cisplatin treatment in cisplatin-resistant ovarian cancer cell lines. Int J Mol Sci. 2023;24(16):12638.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, et al. IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. Nat Commun. 2021;12(1):3651.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang W, Jiang MJ, Lin Y, Qi Y, Li B. Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop. Discov Oncol. 2024;15(1):145.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang WJ, Guo SB, Shi H, Li XL, Zhu Y, Li M, et al. The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance. J Exp Clin Cancer Res: CR. 2023;42(1):105.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huo Q, Wang J, Xie N. High HSPB1 expression predicts poor clinical outcomes and correlates with breast cancer metastasis. Bmc Cancer. 2023;23(1):501.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jiang M, Liu L, Huang W, Qi Y, Li Y, Li B. HMGB1-activated tumor-associated macrophages promote migration and invasion via NF-kappaB/IL-6 signaling in oral squamous cell carcinoma. Int Immunopharmacol. 2024;126:111200.

Article  PubMed  CAS  Google Scholar 

Kai K, Moriyama M, Haque ASMR, Hattori T, Chinju A, Hu C, et al. Oral squamous cell carcinoma contributes to differentiation of monocyte-derived tumor-associated macrophages via PAI-1 and IL-8 production. Int J Mol Sci. 2021;22(17):9475.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karademir D, Ozgur A. Small molecule heat shock protein 27 inhibitor J2 decreases ovarian cancer cell proliferation via induction of apoptotic pathways. Med Oncol. 2023;40(9):250.

Article  PubMed  CAS  Google Scholar 

Kashani B, Zandi Z, Pourbagheri-Sigaroodi A, Bashash D, Ghaffari SH. The role of toll-like receptor 4 (TLR4) in cancer progression: A possible therapeutic target? J Cell Physiol. 2021;236(6):4121–37.

Article  PubMed  CAS  Google Scholar 

Khan R, Siddiqui NN, Ul Haq A, Rahman MA. Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker. Tumour Biol: J Int Soc Oncodevelopmental Biol Med. 2016;37(1):715–21.

Article  CAS  Google Scholar 

Karri RL, Subramanyam RV, Venigella A, Babburi S, Pinisetti S, Rudraraju A. Differential expression of heat shock protein 27 in oral epithelial dysplasias and squamous cell carcinoma. J Microsc Ultrastruct. 2020;8(2):62–8.

Article  PubMed  PubMed Central  Google Scholar 

Kim S-Y, Park JE, Lee H-J, Sim DY, Ahn C-H, Park S-Y, et al. Astragalus membranaceus extract induces apoptosis via generation of reactive oxygen species and inhibition of heat shock protein 27 and androgen receptor in prostate cancers. Int J Mol Sci. 2024;25(5):2799.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Konsgen D, Klinkmann G, Kaul A, Diesing K, Sehouli J, Braicu I, et al. Soluble heat-shock protein 27 in blood serum is a non-invasive prognostic biomarker for ovarian cancer. Eur J Obstet Gynecol Reprod Biol. 2020;255:154–9.

Article  PubMed  Google Scholar 

Laurino S, Brancaccio M, Angrisano T, Calice G, Russi S, Mazzone P, et al. Role of IL-6/STAT3 axis in resistance to cisplatin in gastric cancers. Biomedicines. 2023;11(3):694.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin Y, Qi Y, Jiang M, Huang W, Li B. Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. Int Immunopharmacol. 2023;124(Pt B): 110972.

Article  PubMed  CAS  Google Scholar 

Liang Y, Wang Y, Zhang Y, Ye F, Luo D, Li Y, et al. HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer. Cell Death Dis. 2023;14(7):434.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu K, Yuan X, Yang T, Deng D, Chen Y, Tang M, et al. Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies. J Med Chem. 2024;67(1):245–71.

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