Quercetin can improve anesthesia induced neuroinflammation and cognitive dysfunction by regulating miR-138-5p/ LCN2

Tanino M, Kobayashi M, Sasaki T, Takata K, Takeda Y, Mizobuchi S, et al. Isoflurane induces transient impairment of Retention of spatial Working memory in rats. Acta Med Okayama. 2016;70(6):455–60. https://doi.org/10.18926/amo/54808.

Article  PubMed  Google Scholar 

Cao Y, Li Z, Li H, Ni C, Li L, Yang N, et al. Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD. Behav Brain Res. 2018;339:39–46. https://doi.org/10.1016/j.bbr.2017.09.004.

Article  CAS  PubMed  Google Scholar 

Li C, Shi J, Sun J, Shi Y, Jia H. Cannabinoid receptor 2 deficiency enhances isoflurane-induced spatial cognitive impairment in adult mice by affecting neuroinflammation, neurogenesis and neuroplasticity. Experimental Therapeutic Med. 2021;22(2):908. https://doi.org/10.3892/etm.2021.10340.

Article  CAS  Google Scholar 

Chong H, Xi Y, Zhou Y, Wang G. Protective effects of chlorogenic acid on isoflurane-induced cognitive impairment of aged mice. Food Sci Nutr. 2022;10(10):3492–500. https://doi.org/10.1002/fsn3.2952.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge X, Zuo Y, Xie J, Li X, Li Y, Thirupathi A, et al. A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism. Aging. 2021;13(18):22375–89. https://doi.org/10.18632/aging.203544.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sonawane D, Pokharkar V. Quercetin-loaded Nanostructured lipid carrier in situ gel for Brain Targeting through Intranasal Route: Formulation, in vivo pharmacokinetic and pharmacodynamic studies. AAPS PharmSciTech. 2024;25(2):30. https://doi.org/10.1208/s12249-024-02736-7.

Article  CAS  PubMed  Google Scholar 

Liu Y, Hong H, Xue J, Luo J, Liu Q, Chen X, et al. Near-Infrared Radiation-assisted drug delivery nanoplatform to realize blood-brain Barrier Crossing and Protection for Parkinsonian Therapy. ACS Appl Mater Interfaces. 2021;13(31):37746–60. https://doi.org/10.1021/acsami.1c12675.

Article  CAS  PubMed  Google Scholar 

Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, et al. Quercitrin rapidly alleviated Depression-like behaviors in Lipopolysaccharide-treated mice: the involvement of PI3K/AKT/NF-κB signaling suppression and CREB/BDNF Signaling Restoration in the Hippocampus. ACS Chem Neurosci. 2021;12(18):3387–96. https://doi.org/10.1021/acschemneuro.1c00371.

Article  CAS  PubMed  Google Scholar 

Xu C, Niu JJ, Zhou JF, Wei YS. MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. Brain Res Bull. 2019;144:140–8. https://doi.org/10.1016/j.brainresbull.2018.09.001.

Article  CAS  PubMed  Google Scholar 

Hou Q, Li S, Zhang B, Chu H, Ni C, Fei X, et al. LncRNA Riken attenuated Sevoflurane-Induced Neuroinflammation by regulating the MicroRNA-101a/MKP-1/JNK pathway. Neurotox Res. 2022;40(1):186–97. https://doi.org/10.1007/s12640-021-00443-w.

Article  CAS  PubMed  Google Scholar 

Ye J, Zhang Z, Wang Y, Chen C, Xu X, Yu H, et al. Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis. Experimental Therapeutic Med. 2016;12(3):1299–310. https://doi.org/10.3892/etm.2016.3452.

Article  CAS  Google Scholar 

Xun J, Du L, Gao R, Shen L, Wang D, Kang L, et al. Cancer-derived exosomal mir-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B. Theranostics. 2021;11(14):6847–59. https://doi.org/10.7150/thno.51864.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Huai Y, Chen G, Liu S, Zhang Y, Li D, et al. MiR-138-5p targets MACF1 to aggravate aging-related bone loss. Int J Biol Sci. 2022;18(13):4837–52. https://doi.org/10.7150/ijbs.71411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barreda-Manso MA, Soto A, Muñoz-Galdeano T, Reigada D, Nieto-Díaz M, Maza RM. MiR-138-5p upregulation during neuronal maturation parallels with an increase in neuronal survival. Int J Mol Sci. 2023;24(22). https://doi.org/10.3390/ijms242216509.

Feng F, Zhan Z, Luo D, Hu J, Wei G, Hua F, et al. LncRNA 4344 promotes NLRP3-related neuroinflammation and cognitive impairment by targeting miR-138-5p. Brain Behav Immun. 2021;98:283–98. https://doi.org/10.1016/j.bbi.2021.08.230.

Article  CAS  PubMed  Google Scholar 

Yang XY, Li QJ, Zhang WC, Zheng SQ, Qu ZJ, Xi Y, et al. AMPK-SIRT1-PGC1α Signal Pathway influences the cognitive function of aged rats in Sevoflurane-Induced Anesthesia. J Mol Neuroscience: MN. 2020;70(12):2058–67. https://doi.org/10.1007/s12031-020-01612-w.

Article  CAS  Google Scholar 

Lian F, Cao C, Deng F, Liu C, Zhou Z. Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating mir-223-3p in aged rats. Cytokine. 2022;150:155783. https://doi.org/10.1016/j.cyto.2021.155783.

Article  CAS  PubMed  Google Scholar 

Shi C, Yi D, Li Z, Zhou Y, Cao Y, Sun Y, et al. Anti-RAGE antibody attenuates isoflurane-induced cognitive dysfunction in aged rats. Behav Brain Res. 2017;322(Pt A):167–76. https://doi.org/10.1016/j.bbr.2017.01.012.

Article  CAS  PubMed  Google Scholar 

Chen C, Li XH, Tu Y, Sun HT, Liang HQ, Cheng SX, et al. Aβ-AGE aggravates cognitive deficit in rats via RAGE pathway. Neuroscience. 2014;257:1–10. https://doi.org/10.1016/j.neuroscience.2013.10.056.

Article  CAS  PubMed  Google Scholar 

Kong X, Lyu W, Lin X, Lin C, Feng H, Xu L, et al. Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis. J Neuroinflamm. 2024;21(1):104. https://doi.org/10.1186/s12974-024-03103-w.

Article  CAS  Google Scholar 

Wang S, Yao J, Zhou B, Yang J, Chaudry MT, Wang M, et al. Bacteriostatic Effect of Quercetin as an antibiotic alternative in vivo and its antibacterial mechanism in Vitro. J Food Prot. 2018;81(1):68–78. https://doi.org/10.4315/0362-028x.Jfp-17-214.

Article  CAS  PubMed  Google Scholar 

Chen T, Zhang X, Zhu G, Liu H, Chen J, Wang Y, et al. Quercetin inhibits TNF-α induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro. Medicine. 2020;99(38):e22241. https://doi.org/10.1097/md.0000000000022241.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Li H, Wang W, Li H. Assessing the anti-inflammatory effects of quercetin using network pharmacology and in vitro experiments. Experimental Therapeutic Med. 2022;23(4):301. https://doi.org/10.3892/etm.2022.11230.

Article  CAS  Google Scholar 

Liu F, Yang Y, Peng W, Zhao N, Chen J, Xu Z, et al. Mitophagy-promoting mir-138-5p promoter demethylation inhibits pyroptosis in sepsis-associated acute lung injury. Inflamm Research: Official J Eur Histamine Res Soc [et al]. 2023;72(2):329–46. https://doi.org/10.1007/s00011-022-01675-y.

Article  CAS  Google Scholar 

Mao X, Luan D, Qi Z. Dysregulation of serum mir-138-5p and its clinical significance in patients with Acute Cerebral infarction. Cerebrovascular diseases (Basel, Switzerland). 2022;51(5):670–7. https://doi.org/10.1159/000523902

Li H, Tang C, Wang D. LncRNA H19 promotes inflammatory response induced by cerebral ischemia-reperfusion injury through regulating the miR-138-5p-p65 axis. Biochemistry and cell biology = Biochimie. et Biol Cellulaire. 2020;98(4):525–36. https://doi.org/10.1139/bcb-2019-0281.

Article  CAS  Google Scholar 

Galleggiante V, De Santis S, Liso M, Verna G, Sommella E, Mastronardi M, et al. Quercetin-Induced mir-369-3p suppresses chronic inflammatory response targeting C/EBP-β. Mol Nutr Food Res. 2019;63(19):e1801390. https://doi.org/10.1002/mnfr.201801390.

Article  CAS  PubMed  Google Scholar 

Wang H, Jiang W, Hu Y, Wan Z, Bai H, Yang Q, et al. Quercetin improves atrial fibrillation through inhibiting TGF-β/Smads pathway via promoting MiR-135b expression. Phytomedicine: Int J Phytotherapy Phytopharmacology. 2021;93:153774. https://doi.org/10.1016/j.phymed.2021.153774.

Article  CAS  Google Scholar 

Saenz-Pipaon G, Jover E, van der Bent ML, Orbe J, Rodriguez JA, Fernández-Celis A, et al. Role of LCN2 in a murine model of hindlimb ischemia and in peripheral artery disease patients, and its potential regulation by miR-138-5P. Atherosclerosis. 2023;385:117343. https://doi.org/10.1016/j.atherosclerosis.2023.117343.

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