Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling

Libby P. The changing landscape of atherosclerosis. Nature. 2021;592:524–33.

Article  PubMed  CAS  Google Scholar 

Insull W Jr. The pathology of atherosclerosis: plaque development and plaque responses to medical treatment. Am J Med. 2009;122:S3–S14.

Article  PubMed  CAS  Google Scholar 

Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al. Atherosclerosis. Nat Rev Dis Prim. 2019;5:56.

Article  PubMed  Google Scholar 

Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317–25.

Article  PubMed  CAS  Google Scholar 

Yuan W, Xia H, Xu Y, Xu C, Chen N, Shao C, et al. The role of ferroptosis in endothelial cell dysfunction. Cell Cycle. 2022;21:1897–914.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xu X, Xu XD, Ma MQ, Liang Y, Cai YB, Zhu ZX, et al. The mechanisms of ferroptosis and its role in atherosclerosis. Biomed Pharmacother. 2024;171:116112.

Article  PubMed  CAS  Google Scholar 

Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22:266–82.

Article  PubMed  PubMed Central  Google Scholar 

Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD, et al. Modulating NRF2 in disease: timing is everything. Annu Rev Pharmacol Toxicol. 2019;59:555–75.

Article  PubMed  CAS  Google Scholar 

Xu P, Lin B, Deng X, Huang K, Zhang Y, Wang N. VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis. Free Radic Biol Med. 2022;193:720–35.

Article  PubMed  CAS  Google Scholar 

He F, Antonucci L, Karin M. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020;41:405–16.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hayes JD, Dinkova-Kostova AT. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci. 2014;39:199–218.

Article  PubMed  CAS  Google Scholar 

Howden R. Nrf2 and cardiovascular defense. Oxid Med Cell Longev. 2013;2013:104308.

Article  PubMed  PubMed Central  Google Scholar 

Alonso-Piñeiro JA, Gonzalez-Rovira A, Sánchez-Gomar I, Moreno JA, Durán-Ruiz MC. Nrf2 and heme oxygenase-1 involvement in atherosclerosis related oxidative stress. Antioxidants (Basel). 2021;10:1463.

Neubauer B, Machura K, Chen M, Weinstein LS, Oppermann M, Sequeira-Lopez ML, et al. Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway. Am J Physiol Am J Physiol Ren Physiol 2009;296:F1006–12.

Article  CAS  Google Scholar 

Bos JL. Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci. 2006;31:680–6.

Article  PubMed  CAS  Google Scholar 

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, et al. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019;129:2775–91.

Article  PubMed  PubMed Central  Google Scholar 

Nakayama A, Albarrán-Juárez J, Liang G, Roquid KA, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI insight. 2020;5:e140485.

He L, Lu H, Chu J, Qin X, Gao J, Chen M, et al. Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis. Front Cardiovasc Med. 2022;9:941946.

Article  PubMed  PubMed Central  CAS  Google Scholar 

He L, Lu H, Ji X, Chu J, Qin X, Chen M, et al. Stimulatory G-protein α subunit modulates endothelial cell permeability through regulation of plasmalemma vesicle-associated protein. Front Pharmacol. 2022;13:941064.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, et al. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest. 2005;115:3217–27.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010;465:483–6.

Article  PubMed  CAS  Google Scholar 

Steiner T, Francescut L, Byrne S, Hughes T, Jayanthi A, Guschina I, et al. Protective role for properdin in progression of experimental murine atherosclerosis. PLoS One. 2014;9:e92404.

Article  PubMed  PubMed Central  Google Scholar 

Li D, Mehta JL. Oxidized LDL, a critical factor in atherogenesis. Cardiovasc Res. 2005;68:353–4.

Article  PubMed  CAS  Google Scholar 

Gan B. How erastin assassinates cells by ferroptosis revealed. Protein Cell. 2023;14:84–6.

PubMed  CAS  Google Scholar 

Marques VB, Leal MAS, Mageski JGA, Fidelis HG, Nogueira BV, Vasquez EC, et al. Chronic iron overload intensifies atherosclerosis in apolipoprotein E deficient mice: Role of oxidative stress and endothelial dysfunction. Life Sci. 2019;233:116702.

Article  PubMed  Google Scholar 

Ouyang S, You J, Zhi C, Li P, Lin X, Tan X, et al. Ferroptosis: the potential value target in atherosclerosis. Cell Death Dis. 2021;12:782.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sun X, Niu X, Chen R, He W, Chen D, Kang R, et al. Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis. Hepatology. 2016;64:488–500.

Article  PubMed  CAS  Google Scholar 

Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019;23:101107.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zheng R, Dong X, Wan C, Shi X, Zhang X, Meyer C. Cistrome Data Browser and Toolkit: analyzing human and mouse genomic data using compendia of ChIP-seq and chromatin accessibility data. Quant Biol. 2020;8:267–76.

Kim S, Yu NK, Kaang BK. CTCF as a multifunctional protein in genome regulation and gene expression. Exp Mol Med. 2015;47:e166.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shao X, Liu K, Fan Y, Ding Z, Chen M, Zhu M, et al. Gαs relays sphingosine-1-phosphate receptor 1 signaling to stabilize vascular endothelial-cadherin at endothelial junctions to control mouse embryonic vascular integrity. J Genet Genomics. 2015;42:613–24.

Article  PubMed  CAS  Google Scholar 

Qin X, He L, Tian M, Hu P, Yang J, Lu H, et al. Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. J Mol Cell Cardiol. 2019;132:49–59.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qin X, Liu S, Lu Q, Zhang M, Jiang X, Hu S, et al. Heterotrimeric G stimulatory protein α subunit is required for intestinal smooth muscle contraction in mice. Gastroenterology. 2017;152:1114–25.e5.

Article  PubMed  CAS  Google Scholar 

留言 (0)

沒有登入
gif