Das NK, Jain C, Sankar A, et al. Modulation of the HIF2alpha-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis[J]. Blood. 2022;139(16):2547–52. https://doi.org/10.1182/blood.2021013452.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang CY, Babitt JL. Liver iron sensing and body iron homeostasis[J]. Blood. 2019;133(1):18–29. https://doi.org/10.1182/blood-2018-06-815894.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Sun Z, Jiang X, et al. Ferroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system[J]. Front Immunol. 2022;13:1049936. https://doi.org/10.3389/fimmu.2022.1049936.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moreno-Navarrete JM, Fernandez-Real JM. Iron: The silent culprit in your adipose tissue[J]. Obes Rev. 2024;25(1): e13647. https://doi.org/10.1111/obr.13647.

Article  PubMed  Google Scholar 

Gao H, Jin Z, Bandyopadhyay G, et al. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis[J]. Cell Metab. 2022;34(8):1201–13. https://doi.org/10.1016/j.cmet.2022.07.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ryan SK, Zelic M, Han Y, et al. Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration[J]. Nat Neurosci. 2023;26(1):12–26. https://doi.org/10.1038/s41593-022-01221-3.

Article  CAS  PubMed  Google Scholar 

Belaidi AA, Masaldan S, Southon A, et al. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy[J]. Mol Psychiatry. 2024;29(2):211–20. https://doi.org/10.1038/s41380-022-01568-w.

Article  CAS  PubMed  Google Scholar 

Fernandez-Real JM, Manco M. Effects of iron overload on chronic metabolic diseases[J]. Lancet Diabetes Endocrinol. 2014;2(6):513–26. https://doi.org/10.1016/S2213-8587(13)70174-8.

Article  CAS  PubMed  Google Scholar 

Camaschella C. Iron-Deficiency Anemia[J]. N Engl J Med. 2015;373(5):485–6. https://doi.org/10.1056/NEJMc1507104.

Article  CAS  PubMed  Google Scholar 

von Haehling S, Jankowska EA, van Veldhuisen DJ, et al. Iron deficiency and cardiovascular disease[J]. Nat Rev Cardiol. 2015;12(11):659–69. https://doi.org/10.1038/nrcardio.2015.109.

Article  CAS  Google Scholar 

Muckenthaler MU, Rivella S, Hentze MW, et al. A Red Carpet for Iron Metabolism[J]. Cell. 2017;168(3):344–61. https://doi.org/10.1016/j.cell.2016.12.034.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dahyaleh K, Sung HK, Prioriello M, et al. Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells[J]. J Cell Physiol. 2021;236(7):5339–51. https://doi.org/10.1002/jcp.30240.

Article  CAS  PubMed  Google Scholar 

Moreno-Navarrete JM, Novelle MG, Catalan V, et al. Insulin resistance modulates iron-related proteins in adipose tissue[J]. Diabetes Care. 2014;37(4):1092–100. https://doi.org/10.2337/dc13-1602.

Article  CAS  PubMed  Google Scholar 

Hinojosa-Moscoso A, Motger-Alberti A, De la Calle-Vargas E, et al. The Longitudinal Changes in Subcutaneous Abdominal Tissue and Visceral Adipose Tissue Volumetries Are Associated with Iron Status[J]. Int J Mol Sci. 2023;24(5):4750. https://doi.org/10.3390/ijms24054750.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tajima S, Ikeda Y, Sawada K, et al. Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice[J]. Am J Physiol Endocrinol Metab. 2012;302(1):E77–86. https://doi.org/10.1152/ajpendo.00033.2011.

Article  CAS  PubMed  Google Scholar 

Oliveras-Canellas N, Latorre J, Santos-Gonzalez E, et al. Inflammatory response to bacterial lipopolysaccharide drives iron accumulation in human adipocytes[J]. Biomed Pharmacother. 2023;166: 115428. https://doi.org/10.1016/j.biopha.2023.115428.

Article  CAS  PubMed  Google Scholar 

Ma S, Dubin AE, Zhang Y, et al. A role of PIEZO1 in iron metabolism in mice and humans[J]. Cell. 2021;184(4):969–82. https://doi.org/10.1016/j.cell.2021.01.024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zarychanski R, Schulz VP, Houston BL, et al. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis[J]. Blood. 2012;120(9):1908–15. https://doi.org/10.1182/blood-2012-04-422253.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saotome K, Murthy SE, Kefauver JM, et al. Structure of the mechanically activated ion channel Piezo1[J]. Nature. 2018;554(7693):481–6. https://doi.org/10.1038/nature25453.

Article  CAS  PubMed  Google Scholar 

Wang S, Cao S, Arhatte M, et al. Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice[J]. Nat Commun. 2020;11(1):2303. https://doi.org/10.1038/s41467-020-16026-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Billesbolle CB, Azumaya CM, Kretsch RC, et al. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms[J]. Nature. 2020;586(7831):807–11. https://doi.org/10.1038/s41586-020-2668-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coffey R, Ganz T. Iron homeostasis: An anthropocentric perspective[J]. J Biol Chem. 2017;292(31):12727–34. https://doi.org/10.1074/jbc.R117.781823.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nemeth E, Ganz T. Hepcidin and Iron in Health and Disease[J]. Annu Rev Med. 2023;74:261–77. https://doi.org/10.1146/annurev-med-043021-032816.

Article  CAS  PubMed  Google Scholar 

Harrison AV, Lorenzo FR, McClain DA. Iron and the Pathophysiology of Diabetes[J]. Annu Rev Physiol. 2023;85:339–62. https://doi.org/10.1146/annurev-physiol-022522-102832.

Article  CAS  PubMed  Google Scholar 

Sagar P, Angmo S, Sandhir R, et al. Effect of hepcidin antagonists on anemia during inflammatory disorders[J]. Pharmacol Ther. 2021;226: 107877. https://doi.org/10.1016/j.pharmthera.2021.107877.

Article  CAS  PubMed  Google Scholar 

Schwartz AJ, Das NK, Ramakrishnan SK, et al. Hepatic hepcidin/intestinal HIF-2alpha axis maintains iron absorption during iron deficiency and overload[J]. J Clin Invest. 2019;129(1):336–48. https://doi.org/10.1172/JCI122359.

Article  PubMed  Google Scholar 

James JV, Varghese J, John NM, et al. Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin[J]. J Nutr Biochem. 2023;111: 109175. https://doi.org/10.1016/j.jnutbio.2022.109175.

Article  CAS  PubMed  Google Scholar 

Teng IC, Tseng SH, Aulia B, et al. Can diet-induced weight loss improve iron homoeostasis in patients with obesity: A systematic review and meta-analysis[J]. Obes Rev. 2020;21(12): e13080.