Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity

Gregory CA, Prockop DJ, Spees JL. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp Cell Res. 2005;306:330–5.

Article  PubMed  CAS  Google Scholar 

Gimble JM, Robinson CE, Wu X, Kelly KA. The function of adipocytes in the bone marrow stroma: an update. Bone. 1996;19:421–8.

Article  PubMed  CAS  Google Scholar 

Zakaria ES, Shafrir ES. Yellow bone marrow as adipose tissue. Proc Soc Exp Biol Med. 1967;124:1265–8.

Article  PubMed  CAS  Google Scholar 

de Paula FJA, Rosen CJ. Structure and Function of Bone Marrow Adipocytes. Compr Physiol. 2017;8:315–49. https://doi.org/10.1002/cphy.c170010.

Article  PubMed  Google Scholar 

Horowitz MC, et al. Bone marrow adipocytes. Adipocyte. 2017;6:193–204. https://doi.org/10.1080/21623945.2017.1367881.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karampinos DC, Ruschke S, Dieckmeyer M, Diefenbach M, Franz D, Gersing AS. Quantitative MRI and spectroscopy of bone marrow. J Magn Reson Imaging. 2018;47:332–53.

Article  PubMed  Google Scholar 

Tratwal J, et al. Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society. Front Endocrinol (Lausanne). 2020;11:65. https://doi.org/10.3389/fendo.2020.00065.

Article  PubMed  Google Scholar 

Scheller EL, Troiano N, VanHoutan JN, Bouxsein MA, Fretz JA, Xi Y, et al. Use of osmium tetroxide staining with microcomputerized tomography to visualize and quantify bone marrow adipose tissue in vivo. Methods Enzymol. 2014;537:123–39.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aparisi Gómez MP, et al. Imaging of Bone Marrow: From Science to Practice. Semin Musculoskelet Radiol. 2022;26:396–411. https://doi.org/10.1055/s-0042-1745803.

Article  PubMed  Google Scholar 

Morris EV, Edwards CM. The role of bone marrow adipocytes in bone metastasis. J Bone Oncol. 2016;5:121–3. https://doi.org/10.1016/j.jbo.2016.03.006.

Article  PubMed  PubMed Central  Google Scholar 

Rosen CJ, Rendina-Ruedy E. Bone marrow adipose tissue: New insights and clinical correlates from Best Practices. Best Pract Res Clin Endocrinol Metab. 2021;35: 101563. https://doi.org/10.1016/j.beem.2021.101563.

Article  PubMed  Google Scholar 

Aparisi Gómez MP, et al. Fat and bone: the multiperspective analysis of a close relationship. Quant Imaging Med Surg. 2020;10:1614–35. https://doi.org/10.21037/qims.2020.01.11.

Article  PubMed  PubMed Central  Google Scholar 

Veldhuis-Vlug AG, Rosen CJ. Clinical implications of bone marrow adiposity. J Intern Med. 2018;283:121–39. https://doi.org/10.1111/joim.12718.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stockman R, Greig ED. The Action of Arsenic on the Bone-Marrow and Blood. J Physiol. 1989;23:376–82.

Article  Google Scholar 

Hardouin P, et al. Bone Marrow Adipose Tissue: To Be or Not To Be a Typical Adipose Tissue? Front Endocrinol (Lausanne). 2016;7:85. https://doi.org/10.3389/fendo.2016.00085.

Article  PubMed  Google Scholar 

Lecka-Czernik B, Stechschulte LA, Czernik PJ, Sherman SB, Huang S, Krings A. Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency. Front Endocrinol (Lausanne). 2017;8:188.

Article  PubMed  PubMed Central  Google Scholar 

Cornish J, Wang T, Lin JM. Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis. Curr Osteoporos Rep. 2018;16:116–22.

Article  PubMed  Google Scholar 

Ambrosi TH, et al. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration. Cell Stem Cell. 2017;20:771-784.e776. https://doi.org/10.1016/j.stem.2017.02.009.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Krings A, Rahman S, Huang S, Lu Y, Czernik PJ, Lecka-Czernik B. Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes. Bone. 2012;50:546–52.

Article  PubMed  CAS  Google Scholar 

Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, et al. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab. 2012;16:394–406.

Article  PubMed  CAS  Google Scholar 

Poloni A, Maurizi G, Serrani F, Mancini S, Zingaretti MC, Frontini A, et al. Molecular and functional characterization of human bone marrow adipocytes. Exp Hematol. 2013;41:558–66.

Article  PubMed  CAS  Google Scholar 

Cuminetti V, Arranz L. Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche. J Clin Med. 2019;8:707. https://doi.org/10.3390/jcm8050707.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Emery JL, Follett GF. Regression of bone-marrow haemopoiesis from the terminal digits in the foetus and infant. Br J Haematol. 1964;10:485–9.

Article  PubMed  CAS  Google Scholar 

Justesen J, et al. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology. 2001;2:165–71. https://doi.org/10.1023/a:1011513223894.

Article  PubMed  CAS  Google Scholar 

Layne MD, et al. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. Faseb j. 2001;15:2733–5. https://doi.org/10.1096/fj.01-0374fje.

Article  PubMed  CAS  Google Scholar 

Yeung DK, Griffith JF, Antonio GE, Lee FK, Woo J, Leung PC. Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging. 2005;22:279–85.

Article  PubMed  Google Scholar 

Bredella MA, Fazeli PK, Miller KK, Misra M, Torriani M, Thomas BJ, et al. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab. 2009;94:2129–36.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li GW, Xu Z, Chen QW, Chang SX, Tian YN, Fan JZ. The temporal characterization of marrow lipids and adipocytes in a rabbit model of glucocorticoid-induced osteoporosis. Skeletal Radiol. 2013;42:1235–44.

Article  PubMed  Google Scholar 

Scheller EL, Doucette Casey R, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding SY, Bredella MA, Fazeli PK, Khoury B, Jepsen KJ, Pilch PF, Klibanski A, Rosen CJ, MacDougald OA. Regionspecific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 2015;6:7808.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tavassoli M. Marrow adipose cells. Histochemical identification of labile and stable components. Arch Pathol Lab Med. 1976;100:16–8.

PubMed  CAS  Google Scholar 

Devlin MJ, Brooks DJ, Conlon C, van Vliet M, Louis L, Rosen CJ, Bouxsein ML. Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice. J Endocrinol. 2016;229:295–306.

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