Advances in silver nanoparticles: unraveling biological activities, mechanisms of action, and toxicity

Abbaszadegan Abbas, Ghahramani Yasamin, Gholami Ahmad, Hemmateenejad Bahram, Dorostkar Samira, Nabavizadeh Mohammadreza, Sharghi Hashem (2015) The effect of charge at the surface of silver nanoparticles on antimicrobial activity against gram-positive and gram-negative bacteria: a preliminary study. J Nanomater 16(1):53. https://doi.org/10.1155/2015/720654

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Ahn E-Y, Jin H, Park Y (2019) Assessing the Antioxidant, Cytotoxic, apoptotic and wound healing properties of silver nanoparticles green-synthesized by plant extracts. Mater Sci Eng C 101:204–216. https://doi.org/10.1016/j.msec.2019.03.095

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Akter M, Atique Ullah AKM, Subrata Banik Md, Sikder T, Hosokawa T, Saito T, Kurasaki M (2021) Green synthesized silver nanoparticles-mediated cytotoxic effect in colorectal cancer cells: NF-κB signal induced apoptosis through autophagy. Biol Trace Elem Res 199(9):3272–3286. https://doi.org/10.1007/s12011-020-02463-7

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Ali S, Wazed SR, Joshi M (2011) Synthesis and characterization of chitosan and silver loaded chitosan nanoparticles for bioactive polyester. Carbohyd Polym 83(2):438–446. https://doi.org/10.1016/j.carbpol.2010.08.004

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Alkhalaf MI, Hussein RH, Hamza A (2020) Green synthesis of silver nanoparticles by nigella sativa extract alleviates diabetic neuropathy through anti-inflammatory and antioxidant effects. Saudi J Biol Sci 27(9):2410–2419. https://doi.org/10.1016/j.sjbs.2020.05.005

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Arunachalam R, Dhanasingh S, Kalimuthu B, Uthirappan M, Rose C, Mandal AB (2012) Phytosynthesis of silver nanoparticles using coccinia grandis leaf extract and its application in the photocatalytic degradation. Colloids Surf B 94(June):226–230. https://doi.org/10.1016/j.colsurfb.2012.01.040

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Asghar MA, Zahir E, Shahid SM, Khan MN, Asghar MA, Iqbal J, Walker G (2018) Iron, copper and silver nanoparticles: green synthesis using green and black tea leaves extracts and evaluation of antibacterial, antifungal and aflatoxin B1 adsorption activity. LWT 90:98–107. https://doi.org/10.1016/j.lwt.2017.12.009

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Asharani PV, Yi Lian Wu, Gong Zhiyuan, Valiyaveettil Suresh (2008) Toxicity of silver nanoparticles in zebrafish models. Nanotechnology. https://doi.org/10.1088/0957-4484/19/25/255102

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Balestri A, Cardellini J, Berti D (2023) Gold and silver nanoparticles as tools to combat multidrug-resistant pathogens. Curr Opin Colloid Interface Sci 66(August):101710. https://doi.org/10.1016/j.cocis.2023.101710

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Barbasz A, Czyżowska A, Piergies N, Oćwieja M (2022) Design cytotoxicity: the effect of silver nanoparticles stabilized by selected antioxidants on melanoma cells. J Appl Toxicol 42(4):570–587. https://doi.org/10.1002/jat.4240

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Bindhu MR, Umadevi M (2015) Antibacterial and catalytic activities of green synthesized silver nanoparticles. Spectrochim Acta Part A Mol Biomol Spectrosc 135(January):373–378. https://doi.org/10.1016/j.saa.2014.07.045

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Bonilla JJ, Artunduaga DJ, Guerrero P, Torres RG, Sáez KI, Fonseca BB, Rozental S, Ortiz CC, López (2017) Green synthesis of silver nanoparticles using maltose and cysteine and their effect on cell wall envelope shapes and microbial growth of Candida Spp. J Nanosci Nanotechnol 17(3):1729–1739. https://doi.org/10.1166/jnn.2017.12822

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Bruna T, Maldonado-Bravo F, Jara P, Caro N (2021) Silver nanoparticles and their antibacterial applications. Int J Mol Sci 22(13):7202. https://doi.org/10.3390/ijms22137202

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Buttacavoli Miriam, Albanese Nadia Ninfa, Di Cara Gianluca, Alduina Rosa, Faleri Claudia, Gallo Michele, Pizzolanti Giuseppe et al (2017) Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation. Oncotarget 9(11):9685–9705. https://doi.org/10.1863/oncotarget.23859

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Chang X, Wang X, Li J, Shang M, Niu S, Zhang W, Li Y et al (2021) Silver nanoparticles induced cytotoxicity in HT22 cells through autophagy and apoptosis via PI3K/AKT/mTOR signaling pathway. Ecotoxicol Environ Saf 208(January):111696. https://doi.org/10.1016/j.ecoenv.2020.111696

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Chen Liang, Meng Xu, Jie Gu, Fan Weiqiang, Abdlli Nouara, Peprah Frank Addai, Wang Niannian et al (2019) Silver nanoparticle toxicity in silkworms: omics technologies for a mechanistic understanding. Ecotoxicol Environ Safety 172:388–95. https://doi.org/10.1016/j.ecoenv.2019.01.055

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Chen C-C, Chen Y-Y, Yeh C-C, Hsu C-W, Shang-Jie Yu, Hsu C-H, Wei T-C et al (2021) Alginate-capped silver nanoparticles as a potent anti-mycobacterial agent against mycobacterium tuberculosis. Front Pharmacol 12:746496. https://doi.org/10.3389/fphar.2021.746496

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Chun Y, Kim J (2021) AMPK–mTOR signaling and cellular adaptations in hypoxia. Int J Mol Sci 22(18):9765. https://doi.org/10.3390/ijms22189765

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Colman BP, Espinasse B, Richardson CJ, Matson CW, Lowry GV, Hunt DE, Wiesner MR, Bernhardt ES (2014) Emerging contaminant or an old toxin in disguise? Silver nanoparticle impacts on ecosystems. Environ Sci Technol 48(9):5229–5236. https://doi.org/10.1021/es405454v

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Daei S, Ziamajidi N, Abbasalipourkabir R, Aminzadeh Z, Vahabirad M (2022) Silver nanoparticles exert apoptotic activity in bladder cancer 5637 cells through alteration of Bax/Bcl-2 genes expression. Chonnam Med J 58(3):102–109. https://doi.org/10.4068/cmj.2022.58.3.102

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Dakal Tikam Chand, Kumar Anu, Majumdar Rita S, Yadav Vinod (2016) Mechanistic basis of antimicrobial actions of silver nanoparticles. Front Microbiol. https://doi.org/10.3389/fmicb.2016.01831

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Das Sumon, Chakraborty Tamalika (2018) A Review on green synthesis of silver nanoparticle and zinc oxide nanoparticle from different plants extract and their antibacterial activity against multi-drug resistant bacteria. J Innovations Pharmaceut Biol Sci 5(4):63–73

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De Matteis Valeria (2017) ‘Exposure to inorganic nanoparticles: routes of entry, immune response biodistribution and in vitro/in vivo toxicity evaluation.’ Toxics. https://doi.org/10.3390/toxics5040029

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