Frontera JA, Fernandez A, Schmidt JM, Claassen J, Wartenberg KE, Badjatia N, et al. Defining vasospasm after subarachnoid hemorrhage: What is the most clinically relevant definition? Stroke. 2009;40(6):1963–8.

Article  PubMed  Google Scholar 

Andersen CR, Fitzgerald E, Delaney A, Finfer S. A systematic review of outcome measures employed in aneurysmal subarachnoid hemorrhage (aSAH) clinical research. Neurocrit Care. 2019;30(3):534–41.

Article  PubMed  Google Scholar 

Hoh BL, Ko NU, Amin-Hanjani S, Chou SH, Cruz-Flores S, Dangayach NS, et al. Guideline for the management of patients with aneurysmal subarachnoid hemorrhage: a guideline from the American heart association/American stroke association. Stroke. 2023;54(7):e314–70. Erratum in: Stroke. 2023;54(12):e516.

Treggiari MM, Rabinstein AA, Busl KM, Caylor MM, Citerio G, Deem S, et al. Guidelines for the neurocritical care management of aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2023;39(1):1–28.

Article  PubMed  Google Scholar 

Veldeman M, Rossmann T, Haeren R, Vossen LV, Weiss M, Conzen C, et al. Delayed cerebral infarction after aneurysmal subarachnoid hemorrhage: location, distribution patterns, infarct load, and effect on outcome. Neurology. 2024;103(3): e209607.

Article  PubMed  Google Scholar 

Crowley RW, Medel R, Dumont AS, Ilodigwe D, Kassell NF, Mayer SA, et al. Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage. Stroke. 2011;42(4):919–23.

Article  PubMed  Google Scholar 

Dodd WS, Laurent D, Dumont AS, Hasan DM, Jabbour PM, Starke RM, et al. Pathophysiology of delayed cerebral ischemia after subarachnoid hemorrhage: a review. J Am Heart Assoc. 2021;10(15): e021845.

Article  PubMed  PubMed Central  Google Scholar 

Hafeez S, Grandhi R. Systematic review of intrathecal nicardipine for the treatment of cerebral vasospasm in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2019;31(2):399–405.

Article  PubMed  Google Scholar 

Dodson V, Majmundar N, El-Ghanem M, Amuluru K, Gupta G, Nuoman R, et al. Intracranial administration of nicardipine after aneurysmal subarachnoid hemorrhage: a review of the literature. World Neurosurg. 2019;125:511-518.e1.

Article  PubMed  Google Scholar 

Stuart D, Christian R, Uschmann H, Palokas M. Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review. JBI Database Syst Rev Implement Rep. 2018;16(10):2013–26.

Article  Google Scholar 

Ehtisham A, Taylor S, Bayless L, Samuels OB, Klein MW, Janzen JM. Use of intrathecal nicardipine for aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm. South Med J. 2009;102(2):150–3.

Article  PubMed  Google Scholar 

Goodson K, Lapointe M, Monroe T, Chalela JA. Intraventricular nicardipine for refractory cerebral vasospasm after subarachnoid hemorrhage. Neurocrit Care. 2008;8(2):247–52.

Article  PubMed  Google Scholar 

Suzuki M, Doi M, Otawara Y, Ogasawara K, Ogawa A. Intrathecal administration of nicardipine hydrochloride to prevent vasospasm in patients with subarachnoid hemorrhage. Neurosurg Rev. 2001;24(4):180–4.

Article  PubMed  Google Scholar 

Shibuya M, Suzuki Y, Enomoto H, Okada T, Ogura K, Sugita K. Effects of prophylactic intrathecal administrations of nicardipine on vasospasm in patients with severe aneurysmal subarachnoid haemorrhage. Acta Neurochir. 1994;131(1–2):19–25.

Article  PubMed  Google Scholar 

Varelas PN, Abdelhak T, Wellwood J, Shah I, Hacein-Bey L, Schultz L, et al. Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage. Neurocrit Care. 2010;13(2):190–8.

Article  PubMed  Google Scholar 

Haley EC Jr, Kassell NF, Torner JC. A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage. A report of the Cooperative Aneurysm Study. J Neurosurg. 1993;78(4):537–47.

Sadan O, Jeong YS, Cohen-Sadan S, Sathialingam E, Buckley EM, Kandiah PA, et al. Cerebrospinal fluid pharmacokinetics of nicardipine following intrathecal administration in subarachnoid hemorrhage patients. J Clin Pharmacol. 2024;64(11):1373–81.

Article  PubMed  Google Scholar 

Grandhi R, Menacho ST, Ravindra VM, Condie C, Taussky P, Hawryluk GW. Correlation of intraventricular nicardipine for refractory vasospasm in aneurysmal subarachnoid hemorrhage with improved neurophysiology on intracranial multimodality monitoring: illustrative case. J Neurosurg Case Lessons. 2022;3(22):CASE22113.

Fujiwara K, Mikawa S, Ebina T. Continuous intrathecal administration of nicardipine using a portable infusion pump system for management of vasospasm after subarachnoid hemorrhage. No Shinkei Geka. 2001;29(1):23–30.

Barth M, Pena P, Seiz M, Thomé C, Muench E, Weidauer S, et al. Feasibility of intraventricular nicardipine prolonged release implants in patients following aneurysmal subarachnoid haemorrhage. Br J Neurosurg. 2011;25(6):677–83.

Article  PubMed  Google Scholar 

Oki S, Kobayashi M, Yoshihara T, Yamada K, Sakoda K, Uozumi T. Effect of cisternal administration of nicardipine hydrochloride on cerebral vasospasm—a preliminary report. Hiroshima J Med Sci. 1987;36(1):75–9.

PubMed  Google Scholar 

Sadan O, Waddel H, Moore R, Feng C, Mei Y, Pearce D, et al. Does intrathecal nicardipine for cerebral vasospasm following subarachnoid hemorrhage correlate with reduced delayed cerebral ischemia? A retrospective propensity score-based analysis. J Neurosurg. 2021;136(1):115–24.

Article  PubMed  Google Scholar 

Wessels L, Wolf S, Adage T, Breitenbach J, Thomé C, Kerschbaumer J, et al. Localized nicardipine release implants for prevention of vasospasm after aneurysmal subarachnoid hemorrhage: a randomized clinical trial. JAMA Neurol. 2024;81(10):1060–5.

Article  PubMed  PubMed Central  Google Scholar 

Munn Z, Peters MD, Stern C, Tufanaru C, McArthur A, Aromataris E. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018;18(1):143.

Article  PubMed  PubMed Central  Google Scholar 

Peters MD, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020;18(10):2119–26.

Article  PubMed  Google Scholar 

Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.

Article  PubMed  Google Scholar 

Sathialingam E, Cowdrick KR, Liew AY, Fang Z, Lee SY, McCracken CE, et al. Microvascular cerebral blood flow response to intrathecal nicardipine is associated with delayed cerebral ischemia. Front Neurol. 2023;14:1052232.

Article  PubMed  PubMed Central  Google Scholar 

Ko SB, Choi HA, Helbok R, Kurtz P, Schmidt JM, Badjatia N, et al. Acute effects of intraventricular nicardipine on cerebral hemodynamics: a preliminary finding. Clin Neurol Neurosurg. 2016;144:48–52.

Article  PubMed  Google Scholar 

Lu N, Jackson D, Luke S, Festic E, Hanel RA, Freeman WD. Intraventricular nicardipine for aneurysmal subarachnoid hemorrhage related vasospasm: assessment of 90 days outcome. Neurocrit Care. 2012;16(3):368–75.

Article  PubMed  Google Scholar 

Webb A, Kolenda J, Martin K, Wright W, Samuels O. The effect of intraventricular administration of nicardipine on mean cerebral blood flow velocity measured by transcranial Doppler in the treatment of vasospasm following aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2010;12(2):159–64.

Article  PubMed  Google Scholar 

Kasuya H, Onda H, Sasahara A, Takeshita M, Hori T. Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage. Neurosurgery. 2005;56(5):895–902.

PubMed  Google Scholar 

Vandenbulcke A, Messerer M, Garvayo Navarro M, Peters DR, Starnoni D, Giammattei L, et al. Cisternal nicardipine for prevention of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a comparative retrospective cohort study. Acta Neurochir. 2024;166(1):133.

Article  PubMed  Google Scholar 

Zahra K, Domingo RA, Turnbull MT, Santos CD, Peacock SH, Jackson DA, et al. Safety and tolerability of concentrated intraventricular nicardipine for poor-grade aneurysmal subarachnoid hemorrhage-related vasospasm. J Pers Med. 2023;13(3):428.

Article  PubMed  PubMed Central  Google Scholar 

Garavaglia J, Hardigan T, Turner R, Monachello G, Khan MB, Hodge JO, et al. Continuous intrathecal medication delivery with the IRRA flow catheter: pearls and early experience. Oper Neurosurg. 2024;26(3):293–300.

Google Scholar 

Carrera DA, Marsh LM, Roach JJ, Sarangarm P, Cole CD, Torbey MT, et al. HummingFlow: novel single twist-drill access for ventricular drainage, irrigation, monitoring, and automated local drug delivery in subarachnoid hemorrhage. J Neurosurg. 2023;139(4):1036–41.

Article  PubMed  Google Scholar 

National Center for Biotechnology Information PubChem Compound Summary for CID 41114. Nicardipine hydrochloride. 2024.

Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391–5.

Article  PubMed  Google Scholar 

Vergouwen MD. Participants in the international multi-disciplinary consensus conference on the critical care management of subarachnoid hemorrhage. vasospasm versus delayed cerebral ischemia as an outcome event in clinical trials and observational studies. Neurocrit Care. 2011;15(2):308–11.

NCT06329635: Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial. National Library of Medicine. 2024.

Zhu W, Ling X, Petersen JD, Liu J, Xiao A, Huang J. Clipping versus coiling for aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis of prospective studies. Neurosurg Rev. 2022;45(2):1291–302.