Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 97 - 112
DOI: 10.13189/app.2025.130111
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Snigdha Bhardwaj *, Kandasamy Nagarajan
KIET School of Pharmacy, Ghaziabad, Delhi-NCR, India

ABSTRACT

Candida albicans (C. albicans), the most common and dangerous pathogenic fungus, has been identified as a nosocomial acquired pathogen. Quorum sensing is one method for developing resistance (QS). QS is a cellular mechanism that enables microorganisms to control gene expression in response to changes in cell density through chemical signaling pathways. The pathogenicity of C. albicans is demonstrated by several mechanisms, such as the creation of biofilms, the synthesis of deactivate enzymes, the capacity for phenotypic shifting, and the ability to swiftly transition from the blastophore phase to the hyphal state. Patients who have chronic infections where antibiotics easily take over the host cells but are unable to penetrate the QS mediated biofilms make the antibiotic resistance problem in cases of infections caused by C. albicans more concerning. The anti-virulence agent reduces the pathogenicity without eradicating the target strain, rather than applying abrupt selective pressure to growing microbes. This review presents a current state of scientific research concerning the quorum sensing mechanism in fungi and natural compounds that have been identified as quorum sensing inhibitors and purportedly impede the morphogenic transition of the fungal population. A number of naturally occurring substances, specifically Candida albicans, are emphasized as potentially effective materials with high anti-QS capacities when used as isolated principal components.

KEYWORDS
Candida albicans, Resistance, Quorum Sensing, Biofilms, Quorum Sensing Inhibitors, Natural Products

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Snigdha Bhardwaj , Kandasamy Nagarajan , "Drug Resistance in Candida albicans and Its Novel Anti-quorum Sensing Treatment Approach: A Short Review," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 97 - 112, 2025. DOI: 10.13189/app.2025.130111.

(b). APA Format:
Snigdha Bhardwaj , Kandasamy Nagarajan (2025). Drug Resistance in Candida albicans and Its Novel Anti-quorum Sensing Treatment Approach: A Short Review. Advances in Pharmacology and Pharmacy, 13(1), 97 - 112. DOI: 10.13189/app.2025.130111.