Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 63 - 70
DOI: 10.13189/app.2025.130107
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Weiam A. Hussein 1,2,*, Maali D. Alshammari 1, Weam M. A. Khojali 1,3, Nasrin E. Khalifa 4,5, Abrar A. Alrashidi 1, Albndary M. Alenezi 1, Donia A. Alshelaly 1, Wejdan.S. Alshehri 1, Haya A. Albakr 1, Shahad M. Alshahrani 1, Norah A. Alenezi 1
1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Saudi Arabia
2 Department of Pharmaceutical Chemistry, College of Pharmacy, Aden University, Yemen
3 Department of Pharmaceutical Chemistry, College of Pharmacy, Omdurman Islamic University, Sudan
4 Department of Pharmaceutics, College of Pharmacy, University of Hail, Saudi Arabia
5 Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Sudan

ABSTRACT

In order to facilitate the development of a constituent for traditional medicine, preliminary research pertaining to the detection of secondary metabolites is essential. H. persicum is one of the significant plants in Saudi Arabia, notably in the city of Hail. Analyzing the phytochemical composition of the flavonoid-rich aerial portion of H. persicum with the intention of identifying potentially efficacious medicinal compounds is the principal objective of this study. The extracts contained flavonoids, tannins, alkaloids, and phenolic compounds, as determined by an initial phytochemical analysis. Subsequently, the fraction abundant in flavonoids was identified, and the crude extract's constituents were assessed using the economical, and expeditious thin layer chromatography method. In order to optimize the differentiation of the botanical constituents present in the flavonoid extract, gas chromatography–mass spectrometry was employed. The current investigation additionally aimed to assess the molecular docking and antibacterial activity of the flavonoid-rich fraction of H. persicum, given a shortage of research on this plant. The most potent results were obtained from H. persicum against Pseudomonas aeruginosa and Proteus merabiles.

KEYWORDS
Haloxylon persicum, Phytochemical Screening, Flavonoids, Thin Layer Chromatography, GC-MS, Antibacterial Screening

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Weiam A. Hussein , Maali D. Alshammari , Weam M. A. Khojali , Nasrin E. Khalifa , Abrar A. Alrashidi , Albndary M. Alenezi , Donia A. Alshelaly , Wejdan.S. Alshehri , Haya A. Albakr , Shahad M. Alshahrani , Norah A. Alenezi , "Insights into TLC Profiling, Preliminary Phytochemical Screening, Molecular Docking & Antibacterial Activity of Flavonoid Rich Fraction of Haloxylon persicum," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 63 - 70, 2025. DOI: 10.13189/app.2025.130107.

(b). APA Format:
Weiam A. Hussein , Maali D. Alshammari , Weam M. A. Khojali , Nasrin E. Khalifa , Abrar A. Alrashidi , Albndary M. Alenezi , Donia A. Alshelaly , Wejdan.S. Alshehri , Haya A. Albakr , Shahad M. Alshahrani , Norah A. Alenezi (2025). Insights into TLC Profiling, Preliminary Phytochemical Screening, Molecular Docking & Antibacterial Activity of Flavonoid Rich Fraction of Haloxylon persicum. Advances in Pharmacology and Pharmacy, 13(1), 63 - 70. DOI: 10.13189/app.2025.130107.