Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 1 - 9
DOI: 10.13189/app.2025.130101
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Deependra Soni 1,2, Renjil Joshi 2, Hemkanti Patel 3, Anshita Gupta 4,*, Chanchal Deep Kaur 4
1 Faculty of Pharmacy, MATS University Campus, Aarang, Raipur, Chhattisgarh, India
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh, India
3 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India
4 Rungta College of Pharmaceutical Sciences and Research, Raipur, Chhattisgarh, India

ABSTRACT

Helicteres isora is a plant with several hidden therapeutic potentials. Due to its possible medicinal benefits, the plant technically called "Indian Screw Tree," Helicteres isora, is frequently used in conventional medical practices. The research presented here seeks to assess the anti-inflammatory and anti-convulsant effects of an extract from Helicteres isora. Rats' paw edema was produced using carrageenan in order to test the anti-inflammatory action. The Helicteres isora extract was given orally in a variety of dosages, and the measurement of paw edema was done periodically. The results indicate a significant reduction in paw edema, highlighting the potential of Helicteres isora extract in alleviating inflammation. In order to evaluate the anti-convulsant activity, mice were induced with convulsions using pentylenetetrazole (PTZ). Various doses of the extract were administered intraperitoneally prior to inducing convulsions. The extract exhibited a dose-dependent decrease in seizure severity and duration, demonstrating its effectiveness as an anti-convulsant. These results support the traditional usage of Helicteres isora in the management of convulsive disorders and inflammatory diseases. It was shown that the extract, when given to rats at dosages of 400 mg/kg, significantly reduced their paw edema after receiving carrageenan over a period of 4 hours. Moreover, when given at a dosage of 400 mg/kg, the extract effectively delayed the onset of convulsions and shortened their duration in the convulsion technique induced by PTZ. These findings suggest that the extract derived from Helicteres isora possesses potent properties in terms of reducing inflammation and preventing convulsions, which can be attributed to its bioactive constituents. To further comprehend the mechanisms behind these effects and identify the specific active substances responsible, additional research is warranted.

KEYWORDS
Helicteres isora, Indian Screw Tree, Anti-Inflammatory Effect, Anti-Convulsant Effect, Carrageenan-induced Paw Edema, Pentylenetetrazole-induced Convulsions

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Deependra Soni , Renjil Joshi , Hemkanti Patel , Anshita Gupta , Chanchal Deep Kaur , "Evaluation of Helicteres isora for its Anti-Inflammatory and Anti-Convulsant Activities," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 1 - 9, 2025. DOI: 10.13189/app.2025.130101.

(b). APA Format:
Deependra Soni , Renjil Joshi , Hemkanti Patel , Anshita Gupta , Chanchal Deep Kaur (2025). Evaluation of Helicteres isora for its Anti-Inflammatory and Anti-Convulsant Activities. Advances in Pharmacology and Pharmacy, 13(1), 1 - 9. DOI: 10.13189/app.2025.130101.