Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 78 - 89
DOI: 10.13189/app.2025.130109
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Hital Shah 1, Hardik Savsani 2, Kirti Patel 3, Tejal Gandhi 2,*
1 Gujarat Technological University, India
2 Department of Pharmacology, Anand Pharmacy College, India
3 Department of Pharmacology, M.S. University, India

ABSTRACT

The arachidonic acid (AA) pathway is important in cardiovascular and inflammatory illnesses. Phospholipase A2, a free form of AA, has been metabolized by cytochrome P-450 (CYP450) enzymes, namely the CYP2C (CYP2C6) family (the human analog to CYP2C9), responsible for oxidative stress. This results in the formation of significant mediators: epoxyeicosatrienoic acids (EETs), considered a novel therapeutic target for cardiovascular disease prevention. Fenofibrate,- PPAR-α agonist affects AA metabolism by CYP-450 epoxygenase, resulting in increased synthesis of endogenous EETs having cardioprotective effects. The present investigation sought to determine the effect of fenofibrate on CYP2C6 activity in rats with isoproterenol-induced myocardial infarction. Administration of fenofibrate (100 mg/kg & 150 mg/kg) for four weeks appears to improve mean blood pressure, tachycardia, and cardiac marker enzymes (CK-MB, LDH, and α-HBDH). Fenofibrate dramatically lowered CYP2C6 activity by alleviating oxidative stress through lipid peroxidation (MDA) and restoring natural antioxidant enzymes (SOD, GSH, Catalase). Furthermore, fenofibrate administration restores membrane ATPase activity (Ca++ATPase and Na+/K+ATPase), electrolyte levels (Ca++, Na+, and K+), and prevents ST-segment elevation. Histopathological observations confirm these findings, indicating that the structural architecture of myofibers is preserved and neutrophil infiltration is reduced. According to the current findings, the reduction of CYP2C6 (Human CYP2C9) is an intriguing strategy for the treatment of myocardial infarction and provides novel perspectives for cardiovascular research. In-depth, clinical research is needed to understand the fully effective role of CYP enzymes and their efficacy in the regulation of cardiovascular diseases in individuals.

KEYWORDS
CYP2C6, MI, Fenofibrate

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Hital Shah , Hardik Savsani , Kirti Patel , Tejal Gandhi , "The Influence of Fenofibrate on Cardiac CYP2C6 in Rats with Myocardial Infarction," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 78 - 89, 2025. DOI: 10.13189/app.2025.130109.

(b). APA Format:
Hital Shah , Hardik Savsani , Kirti Patel , Tejal Gandhi (2025). The Influence of Fenofibrate on Cardiac CYP2C6 in Rats with Myocardial Infarction. Advances in Pharmacology and Pharmacy, 13(1), 78 - 89. DOI: 10.13189/app.2025.130109.