Glass HC. Hypoxic-ischemic encephalopathy and other neonatal encephalopathies. Continuum (Minneap Minn). 2018;24:57–71.

PubMed  Google Scholar 

Collaborators GBDNSD. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the global burden of Disease Study 2021. Lancet Neurol. 2024;23:344–81.

Article  Google Scholar 

Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010;86:329–38.

Article  PubMed  Google Scholar 

Douglas-Escobar M, Weiss MD. Hypoxic-ischemic encephalopathy: a review for the clinician. JAMA Pediatr. 2015;169:397–403.

Article  PubMed  Google Scholar 

Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012;366:2085–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akula VP, Joe P, Thusu K, Davis AS, Tamaresis JS, Kim S, Shimotake TK, Butler S, Honold J, Kuzniewicz M, et al. A randomized clinical trial of therapeutic hypothermia mode during transport for neonatal encephalopathy. J Pediatr. 2015;166:856–61.

Article  PubMed  Google Scholar 

Lee BL, Glass HC. Cognitive outcomes in late childhood and adolescence of neonatal hypoxic-ischemic encephalopathy. Clin Exp Pediatr. 2021;64:608–18.

Article  PubMed  PubMed Central  Google Scholar 

Martinez-Biarge M, Diez-Sebastian J, Kapellou O, Gindner D, Allsop JM, Rutherford MA, Cowan FM. Predicting motor outcome and death in term hypoxic-ischemic encephalopathy. Neurology. 2011;76:2055–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Biarge M, Bregant T, Wusthoff CJ, Chew AT, Diez-Sebastian J, Rutherford MA, Cowan FM. White matter and cortical injury in hypoxic-ischemic encephalopathy: antecedent factors and 2-year outcome. J Pediatr. 2012;161:799–807.

Article  PubMed  Google Scholar 

Beck J, Loron G, Ancel PY, Alison M, Hertz Pannier L, Vo Van P, Debillon T, Bednarek N. An updated overview of MRI injuries in neonatal Encephalopathy: LyTONEPAL Cohort. Children (Basel). 2022;9.

Maiza A, Hamoudi R, Mabondzo A. Targeting the multiple complex processes of Hypoxia-Ischemia to Achieve Neuroprotection. Int J Mol Sci 2024;25.

Tao Y, Zhang SC. Neural subtype specification from human pluripotent stem cells. Cell Stem Cell. 2016;19:573–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palma-Tortosa S, Tornero D, Gronning Hansen M, Monni E, Hajy M, Kartsivadze S, Aktay S, Tsupykov O, Parmar M, Deisseroth K, et al. Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior. Proc Natl Acad Sci U S A. 2020;117:9094–100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong M, Tao Y, Gao Q, Feng B, Yan W, Zhou Y, Kotsonis TA, Yuan T, You Z, Wu Z, et al. Human stem cell-derived neurons repair circuits and restore neural function. Cell Stem Cell. 2021;28:112–26. e116.

Article  CAS  PubMed  Google Scholar 

Ji X, Zhou Y, Gao Q, He H, Wu Z, Feng B, Mei Y, Cheng Y, Zhou W, Chen Y, et al. Functional reconstruction of the basal ganglia neural circuit by human striatal neurons in hypoxic-ischaemic injured brain. Brain. 2023;146:612–28.

Article  PubMed  Google Scholar 

Bystron I, Rakic P, Molnar Z, Blakemore C. The first neurons of the human cerebral cortex. Nat Neurosci. 2006;9:880–6.

Article  CAS  PubMed  Google Scholar 

Rakic P. Evolution of the neocortex: a perspective from developmental biology. Nat Rev Neurosci. 2009;10:724–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Sousa AMM, Gao T, Skarica M, Li M, Santpere G, Esteller-Cucala P, Juan D, Ferrandez-Peral L, Gulden FO et al. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science 2018;362.

Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, et al. Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Volume 8. Elife; 2019.

Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, van den Ameele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann SN, et al. An intrinsic mechanism of corticogenesis from embryonic stem cells. Nature. 2008;455:351–7.

Article  CAS  PubMed  Google Scholar 

Shi Y, Kirwan P, Smith J, Robinson HP, Livesey FJ. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat Neurosci. 2012;15:477–86.

Article  CAS  PubMed  Google Scholar 

Espuny-Camacho I, Michelsen KA, Gall D, Linaro D, Hasche A, Bonnefont J, Bali C, Orduz D, Bilheu A, Herpoel A, et al. Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron. 2013;77:440–56.

Article  CAS  PubMed  Google Scholar 

Otani T, Marchetto MC, Gage FH, Simons BD, Livesey FJ. 2D and 3D stem cell models of primate cortical development identify species-specific differences in Progenitor Behavior contributing to brain size. Cell Stem Cell. 2016;18:467–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008;22:152–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi YC, Zhang XJ, Renier N, Wu ZH, Atkin T, Sun ZY, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017;35:154–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kitahara T, Sakaguchi H, Morizane A, Kikuchi T, Miyamoto S, Takahashi J. Axonal extensions along corticospinal tracts from transplanted human cerebral organoids. Stem Cell Rep. 2020;15:467–81.

Article  CAS  Google Scholar 

Aubry L, Bugi A, Lefort N, Rousseau F, Peschanski M, Perrier AL. Striatal progenitors derived from human ES cells mature into DARPP32 neurons and in quinolinic acid-lesioned rats. Proc Natl Acad Sci USA. 2008;105:16707–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, et al. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Rep. 2015;4:360–73.

Article  CAS  Google Scholar 

Real R, Peter M, Trabalza A, Khan S, Smith MA, Dopp J, Barnes SJ, Momoh A, Strano A, Volpi E, et al. In vivo modeling of human neuron dynamics and Down syndrome. Volume 362. Science; 2018.

Hu Y, Fang KH, Shen LP, Cao SY, Yuan F, Su Y, Xu M, Pan Y, Chen Y, Liu Y. The telomerase inhibitor AZT enhances differentiation and prevents overgrowth of human pluripotent stem cell-derived neural progenitors. J Biol Chem. 2018;293:8722–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiller BM, Marmion DJ, Gross RM, Thompson CA, Chavez CA, Brundin P, Wakeman DR, McMahon CW, Kordower JH. Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo. Stem Cells Transl Med. 2021;10:278–90.

Article  CAS  PubMed  Google Scholar 

Okubo T, Iwanami A, Kohyama J, Itakura G, Kawabata S, Nishiyama Y, Sugai K, Ozaki M, Iida T, Matsubayashi K, et al. Pretreatment with a gamma-secretase inhibitor prevents tumor-like overgrowth in human iPSC-Derived transplants for spinal cord Injury. Stem Cell Rep. 2016;7:649–63.

Article  CAS  Google Scholar 

Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY et al. An epigenetic barrier sets the timing of human neuronal maturation. Nature 2024;626.

Sizonenko SV, Kiss JZ, Inder T, Gluckman PD, Williams CE. Distinctive neuropathologic alterations in the deep layers of the parietal cortex after moderate ischemic-hypoxic injury in the P3 immature rat brain. Pediatr Res. 2005;57:865–72.

Article  CAS  PubMed  Google Scholar 

Gris P, Tighe A, Levin D, Sharma R, Brown A. Transcriptional regulation of scar gene expression in primary astrocytes. Glia. 2007;55:1145–55.

Article  PubMed