Engstrand J, Nilsson H, Strömberg C, Jonas E, Freedman J. Colorectal cancer liver metastases—a population-based study on incidence, management and survival. BMC Cancer. 2018;18:78.
Hackl C, Neumann P, Gerken M, Loss M, Klinkhammer-Schalke M, Schlitt HJ. Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma. BMC Cancer. 2014;14:810.
Article PubMed PubMed Central Google Scholar
Punt CJA, Koopman M, Vermeulen L. From tumour heterogeneity to advances in precision treatment of colorectal cancer. Nat Rev Clin Oncol. 2016;14:235–46.
Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, et al. Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, potential cure?. Curr Probl Surg. 2018;55:330–79.
Article PubMed PubMed Central Google Scholar
Petrowsky H, Fritsch R, Guckenberger M, De Oliveira ML, Dutkowski P, Clavien P-A. Modern therapeutic approaches for the treatment of malignant liver tumours. Nat Rev Gastroenterol Hepatol. 2020;17:755–72.
Kanemitsu Y, Shimizu Y, Mizusawa J, Inaba Y, Hamaguchi T, Shida D, et al. Hepatectomy followed by mFOLFOX6 versus hepatectomy alone for liver-only metastatic colorectal cancer (JCOG0603): a phase II or III randomized controlled trial. J Clin Oncol. 2021;39:3789–99.
Article CAS PubMed Google Scholar
Mitry E, Guiu B, Cosconea S, Jooste V, Faivre J, Bouvier AM. Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study. Gut. 2010;59:1383–8.
Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, et al. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. 2018;359:1403–7.
Article CAS PubMed PubMed Central Google Scholar
Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, et al. Origins of lymphatic and distant metastases in human colorectal cancer. Science. 2017;357:55–60.
Article CAS PubMed PubMed Central Google Scholar
Küçükköse E, Laoukili J, Gorelick AN, Degner S, Lacle M, van den Bent L, et al. Lymphatic invasion of plakoglobin-dependent tumor cell clusters drives formation of polyclonal lung metastases in colon cancer. Gastroenterology. 2023;165:429–44.
Chen H-N, Shu Y, Liao F, Liao X, Zhang H, Qin Y, et al. Genomic evolution and diverse models of systemic metastases in colorectal cancer. Gut. 2022;71:322–32.
Article CAS PubMed Google Scholar
Frenkel NC, Poghosyan S, Verheem A, Padera TP, Rinkes IHMB, Kranenburg O, et al. Liver lymphatic drainage patterns follow segmental anatomy in a murine model. Sci Rep. 2020;10:21808.
van den Bent L, Frenkel NC, Poghosyan S, Molenaar IQ, Padera TP, Kranenburg O, et al. Liver lymphatic drainage patterns follow segmental anatomy. Br J Surg. 2022;109:559–60.
Article PubMed PubMed Central Google Scholar
Roy S, Banerjee P, Ekser B, Bayless K, Zawieja D, Alpini G, et al. Targeting lymphangiogenesis and lymph node metastasis in liver cancer. Am J Pathol. 2021;191:2052–63.
Article PubMed PubMed Central Google Scholar
Christophi C, Nguyen L, Muralidharan V, Nikfarjam M, Banting J. Lymphatics and colorectal liver metastases: the case for sentinel node mapping. HPB. 2014;16:124–30.
Korita PV, Wakai T, Shirai Y, Sakata J, Takizawa K, Cruz PV, et al. Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastases. Ann Surgical Oncol. 2007;14:3472–80.
de Ridder JA, Knijn N, Wiering B, de Wilt JH, Nagtegaal ID. Lymphatic invasion is an independent adverse prognostic factor in patients with colorectal liver metastasis. Ann Surgical Oncol. 2015;22:S638–45.
Vellinga TT, Kranenburg O, Frenkel N, Ubink I, Marvin D, Govaert K, et al. Lymphangiogenic gene expression is associated with lymph node recurrence and poor prognosis after partial hepatectomy for colorectal liver metastasis. Ann Surg. 2017;266:765–71.
Chanrion M, Kuperstein I, Barrière C, El Marjou F, Cohen D, Vignjevic D, et al. Concomitant NOTCH activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut. Nat Commun. 2014;5:5005.
Article CAS PubMed Google Scholar
Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 2011;141:1762–72.
Article CAS PubMed Google Scholar
Zhu GX, Gao D, Shao ZZ, Chen L, Ding WJ, Yu QF. Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review). LID-105 [pii] LID—https://doi.org/10.3892/mmr.2020.11744 (1791–3004 (Electronic)).
Zhao H, Ming T, Tang S, Ren S, Yang H, Liu M, et al. Wnt signaling in colorectal cancer: pathogenic role and therapeutic target. Mol Cancer. 2022;21:144.
Kim J, Orkin SH. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med. 2011;3:75.
Article CAS PubMed PubMed Central Google Scholar
Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani SA. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Sci Rep. 2015;5:11766.
Khromova N, Kopnin P, Rybko V, Kopnin BP. Downregulation of VEGF-C expression in lung and colon cancer cells decelerates tumor growth and inhibits metastasis via multiple mechanisms. Oncogene. 2012;31:1389–97.
Article CAS PubMed Google Scholar
Morelli MP, Brown AM, Pitts TM, Tentler JJ, Ciardiello F, Ryan A, et al. Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Mol Cancer Therapeut. 2009;8:2546–58.
Tsai Y-H, Wu A, Wu JH, Capeling MM, Holloway EM, Huang S, et al. Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation. Stem Cell Rep. 2022;17:1138–53.
VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, et al. NOTCH signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. 2012;139:488–97.
Article CAS PubMed PubMed Central Google Scholar
Feng Z, Xu W, Zhang C, Liu M, Wen H. Inhibition of gamma-secretase in NOTCH1 signaling pathway as a novel treatment for ovarian cancer. Oncotarget. 2016;8:8215–8225.
Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 2014;14:159–72.
Article CAS PubMed Google Scholar
Tacconi C, Correale C, Gandelli A, Spinelli A, Dejana E, D’Alessio S, et al. Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion. Gastroenterology. 2015;148:1438–51.e8.
Article CAS PubMed Google Scholar
Jeltsch M, Kaipainen A, Fau-Joukov V, Joukov V, Fau-Meng X, Meng X, et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science. 1997;276:1423–5.
Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science. 1997;276:1423–5.
Article CAS PubMed Google Scholar
Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen Y-L, Pytowski B, et al. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res. 2006;66:8065–75.
Article CAS PubMed Google Scholar
Li X, Liu B, Xiao J, Yuan Y, Ma J, Zhang Y. Roles of VEGF-C and Smad4 in the lymphangiogenesis, lymphatic metastasis, and prognosis in colon cancer. J Gastrointest Surg. 2011;15:2001–10.
Schoppmann A, Tamandl D, Herberger B, Längle F, Birner P, Geleff S, et al. Comparison of lymphangiogenesis between primary colorectal cancer and corresponding liver metastases. Anticancer Res. 2011;31:4605–11.
Lin M, Lin H-Z, Ma S-P, Ji P, Xie D, Yu J-X. Vascular endothelial growth factor-A and -C: expression and correlations with lymphatic metastasis and prognosis in colorectal cancer. Med Oncol. 2010;28:151–8.
Okuno M, Goumard C, Mizuno T, Kopetz S, Omichi K, Tzeng CWD, et al. Prognostic impact of perihepatic lymph node metastases in patients with resectable colorectal liver metastases. Br J Surg. 2018;105:1200–9.
留言 (0)