Sex differences in expression of CGRP family of receptors and ligands in the rat trigeminal system

Steiner TJ, Stovner LJ (2023) Global epidemiology of migraine and its implications for public health and health policy. Nat Reviews Neurol 19(2):109–117

Article  Google Scholar 

Abbafati C, Machado D, Cislaghi B, Salman O, Karanikolos M, McKee M et al (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet 396(10258):1204–1222

Article  Google Scholar 

Steiner T, Stovner L, Jensen R, Uluduz D, Katsarava Z, Headache LTBGC (2020) Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019. Springer, pp 1–4

Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF (2007) Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 68(5):343–349

Article  CAS  PubMed  Google Scholar 

Stovner LJ, Nichols E, Steiner TJ, Abd-Allah F, Abdelalim A, Al-Raddadi RM et al (2018) Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the global burden of Disease Study 2016. Lancet Neurol 17(11):954–976

Article  Google Scholar 

Vetvik KG, MacGregor EA (2021) Menstrual migraine: a distinct disorder needing greater recognition. Lancet Neurol 20(4):304–315

Article  CAS  PubMed  Google Scholar 

Gazerani P, Cairns BE (2020) Sex-specific pharmacotherapy for migraine: a narrative review. Front NeuroSci 14:523475

Article  Google Scholar 

Krause DN, Warfvinge K, Haanes KA, Edvinsson L (2021) Hormonal influences in migraine—interactions of oestrogen, oxytocin and CGRP. Nat Reviews Neurol 17(10):621–633

Article  CAS  Google Scholar 

Warfvinge K, Edvinsson L (2019) Distribution of CGRP and CGRP receptor components in the rat brain. Cephalalgia 39(3):342–353

Article  PubMed  Google Scholar 

Iyengar S, Ossipov MH, Johnson KW (2017) The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine. Pain 158(4):543–559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pietrobon D (2005) Migraine: new molecular mechanisms. Neuroscientist 11(4):373–386

Article  CAS  PubMed  Google Scholar 

Eftekhari S, Salvatore CA, Calamari A, Kane SA, Tajti J, Edvinsson L (2010) Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion. Neuroscience 169(2):683–696

Article  CAS  PubMed  Google Scholar 

Morris HR, Panico M, Etienne T, Tippins J, Girgis SI, MacIntyre I (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308(5961):746–748

Article  CAS  PubMed  Google Scholar 

Russo AF, Hay DL (2023) CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond. Physiol Rev 103(2):1565–1644

Article  CAS  PubMed  Google Scholar 

Rees TA, Hendrikse ER, Hay DL, Walker CS (2022) Beyond CGRP: the calcitonin peptide family as targets for migraine and pain. Br J Pharmacol 179(3):381–399

Article  CAS  PubMed  Google Scholar 

Russo AF (2015) Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol 55:533–552

Article  CAS  PubMed  Google Scholar 

Russell FA, King R, Smillie S-J, Kodji X, Brain S (2014) Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev 94(4):1099–1142

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garelja ML, Hay DL (2022) A narrative review of the calcitonin peptide family and associated receptors as migraine targets: calcitonin gene-related peptide and beyond. Headache: J Head Face Pain 62(9):1093–1104

Article  Google Scholar 

Ghanizada H, Al-Mahdi Al-Karagholi M, Arngrim N, Mørch-Rasmussen M, Walker CS, Hay DL et al (2021) Effect of adrenomedullin on migraine-like attacks in patients with migraine: a randomized crossover study. Neurology 96(20):e2488–e99

Article  PubMed  Google Scholar 

Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W et al (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54(2):233–246

Article  CAS  PubMed  Google Scholar 

Hay DL, Garelja ML, Poyner DR, Walker CS (2018) Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. Br J Pharmacol 175(1):3–17

Article  CAS  PubMed  Google Scholar 

Hendrikse ER, Bower RL, Hay DL, Walker CS (2019) Molecular studies of CGRP and the CGRP family of peptides in the central nervous system. Cephalalgia 39(3):403–419

Article  PubMed  Google Scholar 

Vetvik KG, MacGregor EA (2017) Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol 16(1):76–87

Article  CAS  PubMed  Google Scholar 

Maddahi A, Edvinsson L, Warfvinge K (2022) Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex. J Headache Pain 23(1):1–20

Article  Google Scholar 

Warfvinge K, Krause DN, Maddahi A, Edvinsson JC, Edvinsson L, Haanes KA (2020) Estrogen receptors α, β and GPER in the CNS and trigeminal system-molecular and functional aspects. J Headache Pain 21(1):1–16

Article  Google Scholar 

Krause DN, Warfvinge K, Grell A-S, Edvinsson J, Haanes KA, Edvinsson L (2020) Oxytocin as a regulatory neuropeptide in the trigeminovascular system: localization, expression and function of oxytocin and oxytocin receptors. FASEB J 34(S1):1

Google Scholar 

Warfvinge K, Krause DN, Maddahi A, Grell A-S, Edvinsson JC, Haanes KA et al (2020) Oxytocin as a regulatory neuropeptide in the trigeminovascular system: localization, expression and function of oxytocin and oxytocin receptors. Cephalalgia 40(12):1283–1295

Article  PubMed  Google Scholar 

Maddahi A, Warfvinge K, Holm A, Edvinsson JC, Reducha PV, Kazantzi S et al (2023) Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex. J Headache Pain 24(1):1–16

Article  Google Scholar 

Wimalawansa SJ (1997) Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Reviews™ Neurobiol 11:2–3

Google Scholar 

Edvinsson L, Grell A-S, Warfvinge K (2020) Expression of the CGRP family of neuropeptides and their receptors in the trigeminal ganglion. J Mol Neurosci 70:930–944

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edvinsson JC, Warfvinge K, Krause DN, Blixt FW, Sheykhzade M, Edvinsson L et al (2019) C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system. J Headache Pain 20:1–10

Article  CAS  Google Scholar 

Hansen-Schwartz J, Hoel NL, Zhou M, Xu CB, Svendgaard NA, Edvinsson L (2003) Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery 52(5):1188–1194 (94 – 5)

PubMed  Google Scholar 

Rees TA, Tasma Z, Garelja ML, O’Carroll SJ, Walker CS, Hay DL (2024) Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia. J Headache Pain 25(1):36

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rees TA, Hay DL, Walker CS (2021) Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies. Am J Physiology-Regulatory Integr Comp Physiol 320(5):R697–R703

Article  CAS  Google Scholar 

Edvinsson L, Goadsby PJ (2019) Discovery of CGRP in relation to migraine. SAGE Publications Sage UK, London, England, pp 331–332

Google Scholar 

Edvinsson L (2004) Blockade of CGRP receptors in the intracranial vasculature: a new target in the treatment of headache. Cephalalgia 24(8):611–622

Article  CAS  PubMed 

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