Low-dose arsenic trioxide inhibits pancreatic stellate cell activation via LOXL3 expression to enhance immunotherapy in pancreatic cancer

Mortezaee K. Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer. J Biochem Mol Toxicol. 2021;35:e22708.

Article  PubMed  CAS  Google Scholar 

Henriksen A, Dyhl-Polk A, Chen I, Nielsen D. Checkpoint inhibitors in pancreatic cancer. Cancer Treat Rev. 2019;78:17–30.

Article  PubMed  CAS  Google Scholar 

Majidpoor J, Mortezaee K. The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives. Clin Immunol. 2021;226:108707.

Article  PubMed  CAS  Google Scholar 

Nilsson M, Adamo H, Bergh A, & Halin Bergström S. Inhibition of lysyl oxidase and lysyl oxidase-like enzymes has tumour-promoting and tumour-suppressing roles in experimental prostate cancer. Sci Rep. 2016;6:19608.

Pages F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018;391:2128–39.

Article  PubMed  Google Scholar 

Doi T, Muro K, Ishii H, Kato T, Tsushima T, Takenoyama M, et al. A phase I study of the anti-CC chemokine receptor 4 antibody, mogamulizumab, in combination with nivolumab in patients with advanced or metastatic solid tumors. Clin Cancer Res. 2019;25:6614–22.

Article  PubMed  CAS  Google Scholar 

Hellmann MD, Kim TW, Lee CB, Goh BC, Miller WH, Oh DY, et al. Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors. Ann Oncol. 2019;30:1134–42.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Soignet SL, Maslak P, Wang Z-G, Jhanwar S, Calleja E, Dardashti LJ, et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med. 1998;339:1341–8.

Article  PubMed  CAS  Google Scholar 

Qian C, Wang Y, Chen Y, Zeng L, Zhang Q, Shuai X, et al. Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles. Biomaterials. 2013;34:6175–84.

Article  PubMed  CAS  Google Scholar 

Chen J, Jin Z, Zhang S, Zhang X, Li P, Yang H, et al. Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis. Cell Mol Immunol. 2023;20:51–64.

Article  PubMed  CAS  Google Scholar 

Chen Z, Zhang H, Yang L, Jiang H, Guo S, Li Y, et al. Construction of a metabolomics profile of arsenic trioxide effect in gastric carcinoma cell line SGC7901. Acta Biochim Biophys Sin. 2016;48:474–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duan X, Li T, Han X, Ren J, Chen P, Li H, et al. The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide. Oncotarget. 2017;8:90905–15.

Article  PubMed  PubMed Central  Google Scholar 

Gao J, Wang G, Wu J, Zuo Y, Zhang J, Chen J. Arsenic trioxide inhibits Skp2 expression to increase chemosensitivity to gemcitabine in pancreatic cancer cells. Am J Transl Res. 2019;11:991–7.

PubMed  PubMed Central  CAS  Google Scholar 

Wang QQ, Jiang Y, Naranmandura H. Therapeutic strategy of arsenic trioxide in the fight against cancers and other diseases. Metallomics. 2020;12:326–36.

Article  PubMed  CAS  Google Scholar 

Luo F, Zhuang Y, Sides MD, Sanchez CG, Shan B, White ES, et al. Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo. Respir Res. 2014;15:51.

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Yao H, Yang K, Han S, Chen S, Li Y, et al. Arsenic trioxide-loaded nanoparticles enhance the chemosensitivity of gemcitabine in pancreatic cancer via the reversal of pancreatic stellate cell desmoplasia by targeting the AP4/galectin-1 pathway. Biomater Sci. 2022;10:5989–6002.

Article  PubMed  CAS  Google Scholar 

Pothula SP, Pirola RC, Wilson JS, Apte MV. Pancreatic stellate cells: aiding and abetting pancreatic cancer progression. Pancreatology. 2020;20:409–18.

Article  PubMed  CAS  Google Scholar 

Laurentino TS, Soares RDS, Marie SK N & Oba-Shinjo SM. LOXL3 function beyond amino oxidase and role in pathologies, including cancer. Int J Mol Sci. 2019;20:3587.

Wang, N., Zhou, X., Tang, F., Wang, X. & Zhu, X. Identification of LOXL3-associating immune infiltration landscape and prognostic value in hepatocellular carcinoma. Virchows Archiv Int J Pathol https://doi.org/10.1007/s00428-021-03193-4 (2021).

Santamaría PG, Floristán A, Fontanals-Cirera B, Vázquez-Naharro A, Santos V, Morales S, et al. Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability. Cell Death Differ. 2018;25:935–50.

Article  PubMed  Google Scholar 

Weniger M, Honselmann KC, & Liss AS. The extracellular matrix and pancreatic cancer: a complex relationship. Cancers. 2018;10:316.

DuFort CC, DelGiorno KE, Hingorani SR. Mounting pressure in the microenvironment: fluids, solids, and cells in pancreatic ductal adenocarcinoma. Gastroenterology. 2016;150:1545–1557.e1542.

Article  PubMed  Google Scholar 

Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, et al. Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast-driven nutritional support and immunosuppression. Cancer Discov. 2021;11:446–79.

Article  PubMed  CAS  Google Scholar 

Wu D, Zhu ZQ, Tang HX, Shi ZE, Kang J, Liu Q, et al. Efficacy-shaping nanomedicine by loading calcium peroxide into tumor microenvironment-responsive nanoparticles for the antitumor therapy of prostate cancer. Theranostics. 2020;10:9808–29.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shao Y, Wang L, Fu J, Shi C, Xu J, Zhu Y. Efficient free radical generation against cancer cells by low-dose X-ray irradiation with a functional SPC delivery nanosystem. J Mater Chem B. 2016;4:5863–72.

Article  PubMed  CAS  Google Scholar 

Patsouras D, Papaxoinis K, Kostakis A, Safioleas MC, Lazaris AC, Nicolopoulou-Stamati P. Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma. Mol Med Rep. 2015;11:4585–90.

Article  PubMed  CAS  Google Scholar 

Yamamoto K, Iwadate D, Kato H, Nakai Y, Tateishi K, Fujishiro M. Targeting the metabolic rewiring in pancreatic cancer and its tumor microenvironment. Cancers. 2022;14:4351.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kalim KW, Yang JQ, Wunderlich M, Modur V, Nguyen P, Li Y, et al. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. J Immunother Cancer. 2022;10:e004806.

LaRue MM, Parker S, Puccini J, Cammer M, Kimmelman AC, & Bar-Sagi D. Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer. Proc Natl Acad Sci. 2022;119:e2119168119.

Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, et al. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion. Nat Commun. 2020;11:4520.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Garcia Garcia CJ, Huang Y, Fuentes NR, Turner MC, Monberg ME, Lin D, et al. Stromal HIF2 regulates immune suppression in the pancreatic cancer microenvironment. Gastroenterology. 2022;162:2018–31.

Article  PubMed  CAS  Google Scholar 

Falcomatà C, Bärthel S, Widholz SA, Schneeweis C, Montero JJ, Toska A, et al. Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. 2022;3:318–36.

Article  PubMed  PubMed Central  Google Scholar 

Ro S-H, Bae J, Jang Y, Myers JF, Chung S, Yu J, et al. Arsenic toxicity on metabolism and autophagy in adipose and muscle tissues. Antioxidants. 2022;11:689.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khairul I, Wang QQ, Jiang YH, Wang C, Naranmandura H. Metabolism, toxicity and anticancer activities of arsenic compounds. Oncotarget. 2017;8:23905–26.

Article  PubMed  PubMed Central  Google Scholar 

Tian Z, Tan Y, Lin X, Su M, Pan L, Lin L, et al. Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1/PI3K/AKT/mTOR axis. Transl Res J Lab Clin Med. 2023;255:66–76.

CAS 

留言 (0)

沒有登入
gif