Looking back at the TEDDY study: lessons and future directions

Thomas, N. J. et al. Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes. Diabetologia 62, 1167–1172 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hermann, R. et al. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes – indication of an increased environmental pressure? Diabetologia 46, 420–425 (2003).

Article  CAS  PubMed  Google Scholar 

Gillespie, K. M. et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 364, 1699–1700 (2004).

Article  PubMed  Google Scholar 

Resic-Lindehammer, S. et al. Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk. Acta Diabetol. 45, 231–235 (2008).

Article  CAS  PubMed  Google Scholar 

Fourlanos, S. et al. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care 31, 1546–1549 (2008).

Article  PubMed  PubMed Central  Google Scholar 

Hagopian, W. A. et al. TEDDY – The Environmental Determinants of Diabetes in the Young: an observational clinical trial. Ann. N. Y. Acad. Sci. 1079, 320–326 (2006).

Article  PubMed  Google Scholar 

TEDDY Study Group The Environmental Determinants of Diabetes in the Young (TEDDY) study. Ann. N. Y. Acad. Sci. 1150, 1–13 (2008).

Article  PubMed Central  Google Scholar 

Norris, J. M. Infant and childhood diet and type 1 diabetes risk: recent advances and prospects. Curr. Diab Rep. 10, 345–349 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Elding Larsson, H. et al. Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr. Diabetes 15, 118–126 (2014).

Article  PubMed  Google Scholar 

Lernmark, A. et al. Possible heterogeneity of initial pancreatic islet beta-cell autoimmunity heralding type 1 diabetes. J. Intern. Med. 294, 145–158 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rewers, M. et al. The Environmental Determinants of Diabetes in the Young (TEDDY) study: 2018 update. Curr. Diab Rep. 18, 136 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Stahl, M. et al. Coeliac disease: what can we learn from prospective studies about disease risk? Lancet Child. Adolesc. Health 8, 63–74 (2024).

Article  CAS  PubMed  Google Scholar 

Quinn, L. M., Wong, F. S. & Narendran, P. Environmental determinants of type 1 diabetes: from association to proving causality. Front. Immunol. 12, 737964 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodwin, G. Type 1 diabetes mellitus and celiac disease: distinct autoimmune disorders that share common pathogenic mechanisms. Horm. Res. Paediatr. 92, 285–292 (2019).

Article  CAS  PubMed  Google Scholar 

TEDDY Study Group The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr. Diabetes 8, 286–298 (2007).

Article  Google Scholar 

Bonifacio, E. et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for National Institute of Diabetes and Digestive and Kidney Diseases consortia. J. Clin. Endocrinol. Metab. 95, 3360–3367 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onengut-Gumuscu, S. et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat. Genet. 47, 381–386 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, H. S. et al. Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes Metab. Res. Rev. 30, 424–434 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Hagopian, W. A. et al. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr. Diabetes 12, 733–743 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Baxter, J. et al. Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY study. Contemp. Clin. Trials 33, 633–640 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Johnson, S. B. et al. The Environmental Determinants of Diabetes in the Young (TEDDY) study: predictors of early study withdrawal among participants with no family history of type 1 diabetes. Pediatr. Diabetes 12, 165–171 (2011).

Article  PubMed  Google Scholar 

Lernmark, B. et al. Enrollment experiences in a pediatric longitudinal observational study: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Contemp. Clin. Trials 32, 517–523 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Johnson, S. B. et al. Predicting later study withdrawal in participants active in a longitudinal birth cohort study for 1 year: the TEDDY study. J. Pediatr. Psychol. 41, 373–383 (2016).

Article  PubMed  Google Scholar 

Lernmark, B. et al. Participant experiences in The Environmental Determinants of Diabetes in the Young study: common reasons for withdrawing. J. Diabetes Res. 2016, 2720650 (2016).

Article  PubMed  Google Scholar 

Lernmark, B. et al. Reasons for staying as a participant in The Environmental Determinants of Diabetes in the Young (TEDDY) longitudinal study. J. Clin. Trials 2, 1000114 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Melin, J. et al. Factors assessed in the first year of a longitudinal study predict subsequent study visit compliance: the TEDDY study. Eur. J. Med. Res. 28, 592 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Yang, J. et al. Factors associated with longitudinal food record compliance in a paediatric cohort study. Public. Health Nutr. 19, 804–813 (2016).

Article  PubMed  Google Scholar 

Roth, R. et al. The feasibility of salivary sample collection in an international pediatric cohort: the the TEDDY study. Dev. Psychobiol. 59, 658–667 (2017).

Article  CAS  PubMed  Google Scholar 

Driscoll, K. A. et al. Adherence to oral glucose tolerance testing in children in stage 1 of type 1 diabetes: the TEDDY study. Pediatr. Diabetes 22, 360–368 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vehik, K. et al. Hierarchical order of distinct autoantibody spreading and progression to type 1 diabetes in the TEDDY study. Diabetes Care 43, 2066–2073 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Insel, R. A. et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38, 1964–1974 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krischer, J. P. et al. The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia 58, 980–987 (2015).

Article  CAS 

留言 (0)

沒有登入
gif