Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 10 - 17
DOI: 10.13189/app.2025.130102
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Vidyabhushan Yadav , Hariprasad M.G *, Moqbel Ali Moqbel Redhwan , Rahul Kumar , Apurwa Dhavale , Sourav Guha
Department of Pharmacology, KLE College of Pharmacy, India

ABSTRACT

Elevated blood lipid levels, or hyperlipidemia, represents a major modifiable risk factor for cardiovascular pathologies, including atherosclerosis and ischemic heart disease. The exploration of phytochemicals for lipid modulation offers a valuable avenue for therapeutic development. In this context, the present study aimed to elucidate the lipid-lowering potential of ethanol-derived extracts from Moringa concanensis leaves in a controlled experimental setting. Utilizing thirty albino Wistar rats, this research established five distinct groups, encompassing a standard-diet control group and four high-fat diet cohorts to induce a state of hyperlipidemia. Following a month of dietary manipulation, one group continued without intervention, while two groups received varying doses of the Moringa concanensis extract (200 and 400 mg/kg body weight), and another group received a standard hypolipidemic drug, Rosuvastatin, for comparison. After a total of sixty days, systemic and hepatic markers of lipid metabolism, liver function, and oxidative stress were quantitatively assessed. Notably, the Moringa concanensis extract exhibited a dose-responsive amelioration of dyslipidemia, as evidenced by reductions in TC, triglycerides, LDL-C, VLDL-C, and an elevation in HDL levels. Concurrent enhancements in hepatic function and oxidative stress markers—manifested through lowered malondialdehyde levels and augmented superoxide dismutase, glutathione, and catalase activity—were observed. Histopathological examinations corroborated these findings, revealing diminished fat deposition and inflammation within hepatic tissues. Collectively, these results underscore the therapeutic promise of Moringa concanensis leaf extract as a natural agent for managing hyperlipidemia and associated oxidative stress, warranting further investigation for its clinical applicability.

KEYWORDS
Hyperlipidemia, Moringa Concanensis, Oxidative Stress, Lipid Profile, High-fat Diet

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Vidyabhushan Yadav , Hariprasad M.G , Moqbel Ali Moqbel Redhwan , Rahul Kumar , Apurwa Dhavale , Sourav Guha , "Assessment of the Therapeutic Potential of Ethanolic Extract of Moringa Concanensis Leaves in a Rat Model of High Fat Diet-Induced Hyperlipidaemia," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 10 - 17, 2025. DOI: 10.13189/app.2025.130102.

(b). APA Format:
Vidyabhushan Yadav , Hariprasad M.G , Moqbel Ali Moqbel Redhwan , Rahul Kumar , Apurwa Dhavale , Sourav Guha (2025). Assessment of the Therapeutic Potential of Ethanolic Extract of Moringa Concanensis Leaves in a Rat Model of High Fat Diet-Induced Hyperlipidaemia. Advances in Pharmacology and Pharmacy, 13(1), 10 - 17. DOI: 10.13189/app.2025.130102.